The genetic background of familial, late-onset colorectal cancer (CRC) (i.e., onset > age 50 years) has not been studied as thoroughly as other subgroups of familial CRC, and the proportion of families with a germline genetic predisposition to CRC remains to be defined. To define the contribution of known or suggested CRC predisposition genes to familial late-onset CRC, we analyzed 32 well-establi

Humanity is at a crossroads in addressing biodiversity loss. Several assessments have reported on the weak compliance with the Aichi Biodiversity Targets by the parties to the Convention on Biological Diversity (CBD). To address this lack of compliance, the challenges in implementing and enforcing CBD obligations must be understood. Key implementation challenges of the CBD are identified through a

Glycolipids such as gangliosides affect the properties of lipid membranes and in extension the interactions between membranes and other biomolecules like proteins. To better understand how the properties of individual lipid molecules can contribute to shape the functional aspects of a membrane, the spatial restriction and dynamics of C–H bond segments can be measured using nuclear magnetic re

Korean fathers gained their first entitlement to take one-year paid parental leave in 2001. The policy has since continuously advanced, but as of 2020, fathers’ take-up rates remain low at 3.4%. This dissertation raises the question of why Korean fathers do not take parental leave, and what the nature of the underlying sociocultural contexts is that precipitates this discrepancy. To seek answers t

Parkinson´s disease (PD) is one of the most common neurological diseases with both motor and non-motor symptoms that can be perceived as difficult to control despite medical treatment. This leads to several consequences in everyday life for example difficulties in activities of daily living (ADL), sometimes already at diagnosis. Therefore, rehabilitation is important to manage the consequences of

Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for AML. To identify the molecular context for monotherapy sensitivity as well as rational drug combinations, we profile selinexor signaling responses using phosphoproteomics in primary AML patient samples and cell line

The measurement of biodiversity has been a challenging topic in recent years. Our group uses a remote sensing technique named Scheimflug lidar to monitor insect activity and abundance. A field campaign was conducted back in 2020 at Stensoffa, Sweden, with our lidar system to measure insect activities over a lake. This thesis work aims to develop a method to estimate insect diversity of the data re

Joseph Sheridan Le Fanu var en av de första författarna att tilldela den kvinnliga vampyren en betydande litterär roll i sitt framstående verk Carmilla (1872). Drygt 130 år senare ger Stephenie Meyer nytt liv åt den litterära vampyren i sin roman Twilight (2005) – med en helt annan tolkning av den mytomspunna figuren. Med hjälp av ett feministiskt perspektiv ämnar uppsatsen fördjupa sig i vampyrge