L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f

Surgically revised deep infected primary knee arthroplasties reported to the Swedish knee arthroplasty register during the years 1986-2000 were studied with respect to microbiology, antimicrobial susceptibility pattern and changes over time. In early, delayed and late infections, coagulase-negative staphylococci (CoNS) were most prevalent (105/299, 35.1%), and twice as common as Staphylococcus aur

Background Smokers have a substantially increased risk of postoperative complications. Preoperative smoking intervention may be effective in decreasing this incidence, and surgery may constitute a unique opportunity for smoking cessation interventions. Objectives The objectives of this review are to assess the effect of preoperative smoking intervention on smoking cessation at the time of surgery

In this paper, a numerical model is developed for analyzing the role of species life history and age structure for the optimal management of a commercial resident species that is exposed to an invasive species. It is shown that reproduction and mortality characteristics of both species ands age structure of the invader at the time of invasion are important for the costs of invasions when the invad

The catalytic incorporation of CO2 into value-added chemicals to form e. g. carboxylic acids and carbonates is highly interesting due to the abundance, non-toxicity and low cost of carbon dioxide. Currently, palladium is one of the most exploited transition metals in homogeneous catalysis and its reactivity with carbon dioxide has therefore been studied to a significant extent. All work in the fie

This survey concerns optimization problems arising in the design of survivable communication networks. It turns out that such problems can be modeled in a natural way as non-compact linear programming formulations based on multicommodity flow network models. These non-compact formulations involve an exponential number of path flow variables, and therefore require column generation to be solved to

IT procurement represents a business process of importance, including the ability to articulate requirements that the procurement deals with. Furthermore, specifying requirements is of importance for both procurer, and potential supplier as it functions as central contractual element between the two. The purpose of the article is to show how functional and non-functional requirements are represent

We study the asymptotics of the scenery flow. We give corrected versions with proofs of a certain lemma by Hochman, and study some related phenomena.

BACKGROUND: This study compares the high-frequency QRS components (HF-QRS) in patients with and without standard electrocardiogram (ECG) changes indicative of old myocardial infarction (MI). Previous studies have indicated that patients with an old MI differ in their HF-QRS compared with healthy subjects. The HF-QRS has been reported to be decreased during acute coronary occlusion and increased af

PURPOSE: The purpose was to quantify changes of epileptiform activity during ketogenic diet (KD) treatment in children with therapy resistant epilepsy, and evaluate how these changes are related to activity stage and to clinical effects on seizure frequency, seizure severity, attentional behaviour, quality of life (QOL), and beta-hydroxybutyrate (betaOHb). METHODS: Eighteen children were investiga

OBJECTIVE: In Sweden, a country with high standards of obstetric care, the high rate of perinatal mortality among children of immigrant women from the Horn of Africa raises the question of whether there is an association between female circumcision and perinatal death. METHODS: To investigate this, we examined a cohort of 63 perinatal deaths of infants born in Sweden over the period 1990–96 to cir

Purpose. To describe conceptions, as registered by a semi-structured interview, of exercise as treatment among sixteen middle-aged patients with moderate to severe knee osteoarthritis. Method. Sixteen patients ( aged 39 - 64) with symptomatic, radiographic knee osteoarthritis and previous participants in an exercise intervention, were interviewed. The qualitative data obtained were analysed using

We report the experimental observation of a strongly selective population of the spin-orbit components in the HCl+ (X) over tilde (2)Pi(Omega) states after excitation into the dissociative 2p(-1)6sigma* core excited state. A progression of highly excited vibrational states with either the Omega=3/2 or Omega=1/2 component of the final state is populated, respectively, when the excitation is tuned i

Phase III trials have demonstrated the efficacy of human papillomavirus (HPV) vaccines in preventing transient and persistent high-risk (hr) HPV infection and precancerous lesions. A mathematical model of HPV type 16 infection and progression to cervical cancer, parameterised to represent the infection in Finland, was used to explore the optimal age at vaccination and pattern of vaccine introducti

A commentary about the meaning of "One World Archaeology" today and the future of the World Archaeological Congress (WAC).

The responsiveness of the external mycelium of Glomus intraradices and Scutellospora calospora was tested in a multiple-choice experimental system in which mycelium encountered patches amended with nitrogen (N) or phosphorus (P), either alone or in combination with a host plant. We hypothesised that only AMF mycelium with sufficient supply of photo-synthate from an actively growing host would resp

The Toll-like receptors (TLRs) and the myeloid differentiation factor 88 (MyD88) are key players in the activation of the innate immune defence during microbial infections. Using different murine infection models, we show that MyD88-dependent signalling is crucial for the activation of the innate immune defence against Streptococcus pneumoniae. Our data demonstrate that both local and systemic inf