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A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics

Extensive usage of antibiotics has created an unprecedented scenario of the rapid emergence of many drug-resistant bacteria, which has become an alarming public health concern around the globe. Search for better alternatives that are as efficacious as antibiotics led to the discovery of antimicrobial peptides (AMPs). These small cationic amphiphilic peptides have emerged as a promising option as a

Investigating consecutive conflicts of pedestrian crossing at unsignalized crosswalks using the bivariate logistic approach

Pedestrians confront risky situations at unsignalized crosswalks when they are consecutively interacting with motorized vehicles and non-motorized vehicles while crossing. This study aims to investigate the safety of pedestrians with a new perspective that focuses on consecutive conflicts occurring during pedestrian crossing. Based on about 9 h video data collected by an unmanned aerial vehicle fr

Towards a Pedagogy of the Utopian Image

This practice-based PhD project investigates the conditions for a pedagogy of the utopian image in contemporary art and film. It starts from the premise that there is a need for new political and social visions and scenarios. The project asks what role art and artist film, both as a medium and as a social activity, can play in experimenting with and sketching such visions and scenarios – a process

The Diversity of Eyes and Vision

Every aspect of vision, from the opsin proteins to the eyes and the ways that they serve animal behavior, is incredibly diverse. It is only with an evolutionary perspective that this diversity can be understood and fully appreciated. In this review, I describe and explain the diversity at each level and try to convey an understanding of how the origin of the first opsin some 800 million years ago

Health status of individuals referred to first-line intervention for hip and knee osteoarthritis compared with the general population : An observational register-based study

Objectives To describe the prevalence of comorbidities in a population referred to standardised first-line intervention (patient education and exercise) for hip and knee osteoarthritis (OA), in comparison with the general population. Furthermore, we aimed to evaluate if eventual differences were associated with socioeconomic inequalities. Design Register-based study. Setting Primary healthcare, Sw

Developing shared languages. The fundamentals of mutual learning and problem solving in transdisciplinary collaboration

This issue of the AILA Review focuses on transdisciplinarity as the key to developing shared languages in and across domains and professional settings. The relationship and collaboration between researchers and practitioners have long been discussed within and across applied sciences and theoretical disciplines, mainly in the framework of transdisciplinarity (see AILA Review 31, 2018, for a recent

Codon optimization of insect odorant receptor genes may increase yheir stable expression for functional characterization in HEK293 cells

Insect odorant receptor (OR) genes are routinely expressed in Human Embryonic Kidney (HEK) 293 cells for functional characterization (“de-orphanization”) using transient or stable expression. However, progress in this research field has been hampered because some insect ORs are not functional in this system, which may be due to insufficient protein levels. We investigated whether codon optimizatio

Introducing Negatively Charged Residues on the Surface of Fetal Hemoglobin Improves Yields in Escherichia coli

Fetal hemoglobin (HbF) has been developed into an important alternative protein for oxygen therapeutics. Such applications require extensive amounts of proteins, which only can be achieved via recombinant means. However, the expression of vertebrate hemoglobins in heterologous hosts is far from trivial. There are several issues that need to be dealt with. These include, among others, the solubilit

The Experimental City

This book explores how the concept or urban experimentation is being used to reshape practices of knowledge production in urban debates about resilience, climate change governance, and socio-technical transitions.With contributions from leading scholars, and case studies from the Global North and South, from small- to large-scale cities, this book suggests that urban experiments offer novel modes

Inside Smart Cities : Place, Politics and Urban Innovation

The era of the smart city has arrived. Only a decade ago, the promise of optimising urban services through the widespread application of information and communication technologies was largely a techno-utopian fantasy. Today, smart urbanisation is occurring via urban projects, policies and visions in hundreds of cities around the globe.Inside Smart Cities provides real-world evidence on how local a

Botanizing the Asphalt : Politics of Urban Drainage

Modern cities are often perceived as the antithesis of nature; the built environment is understood as the transformation of raw and untamed nature into a rationalized human landscape. However, a variety of scholars since the nineteenth century have noted the persistence of nature in cities, not only in providing essential services but also resisting human control. Most recently, urban geographers

Repeated Parental Singing During Kangaroo Care Improved Neural Processing of Speech Sound Changes in Preterm Infants at Term Age

Preterm birth carries a risk for adverse neurodevelopment. Cognitive dysfunctions, such as language disorders may manifest as atypical sound discrimination already in early infancy. As infant-directed singing has been shown to enhance language acquisition in infants, we examined whether parental singing during skin-to-skin care (kangaroo care) improves speech sound discrimination in preterm infant

Supporting, tinkering, adjusting and resisting : a typology of user translations of the built environment

PurposeArchitectural theorists have a long tradition of acknowledging the centrality of building users to architectural production. This article contributes to the discourse on architecture, actor–network theory (ANT), and users by proposing a typology of user translations ranging from supporting to tinkering to adjusting to resisting.Design/methodology/approachThe research utilises an ANT-inspire

Trust in the academy : a conceptual framework for understanding trust on academic web profiles

Purpose: Institutional and commercial web profiles that provide biobibliographic information about researchers are used for promotional purposes but also as information sources. In the latter case, the profiles' (re)presentations of researchers may be used to assess whether a researcher can be trusted. The article introduces a conceptual framework of how trust in researchers may be formed based on