A mouse monoclonal antibody (MAB 9,9) to coagulation factor IX (F.IX) detects a polymorphism in the plasma of normal people. Its epitope has been narrowed down to

The case of a female with moderate haemophilia B is reported. She is the only affected member of her family, and factor IX RFLP analysis shows her to have inherited no maternal markers for polymorphisms located in the first intron and 8 Kb 3' of the polyadenylation signal (DdeI and HhaI, respectively). This clearly indicates a deletion involving at least the last 7 exons of the factor IX gene. Her

A 39‐year‐old patient, suffering from severe haemophilia B and antibodies against factor IX, has twice been treated with extracorporeal protein A‐Sepharose adsorption followed by conventional substitution therapy in combination with immunosuppression (cyclophos‐phamide). On both occasions, separated by a 2‐year interval, the same procedure was followed except that, on the second, administration of

Green-plant thylakoids increase satiety by affecting appetite hormones such as ghrelin, cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). The objective of this study was to investigate if thylakoids also affect gastrointestinal (GI) passage and microbial composition. To analyse the effects on GI passage, 16 rats were gavage-fed a control or thylakoid-supplemented high-fat diet (HFD) 30 mi

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5).

Use of a second harmonic and third harmonic cavity within a klystron to increase efficiency has been studied using particle-in-cell (PIC) code, MAGIC 2D. The six cavity device has a drive frequency of 1GHz, a predicted efficiency of 88%, 39 dB gain and an output power of 833 kW. The preliminary simulation results have revealed indications of bunching with bunch core oscillations. The initial resul

In order to add to the existing knowledge on the complex institutional dynamics of negotiating conflicts and compatibilities in innovation processes that address societal challenges and social needs, this article scrutinizes the scientific and societal debate on the theoretical and practical application of “social innovation” by means of the concept “boundary object” linked to institutional theoryIn order to add to the existing knowledge on the complex institutional dynamics of negotiating conflicts and compatibilities in innovation processes that address societal challenges and social needs, this article scrutinizes the scientific and societal debate on the theoretical and practical application of “social innovation” by means of the concept “boundary object” linked to institutional theory

The ability of biological molecules to replicate themselves is the foundation of life, requiring a complex cellular machinery. However, a range of aberrant processes involve the self-replication of pathological protein structures without any additional assistance. One example is the autocatalytic generation of pathological protein aggregates, including amyloid fibrils, involved in neurodegenerativ

Aspects of laser spectroscopy applied to the biomedical fields are reviewed with examples illustrating the techniques taken mostly from the author's research experience. Basic principles of quantum-mechanical background are described, and powerful implementations in the biophotonics field are discussed.

Post-traumatic stress disorder (PTSD) is a common and disabling disorder that develops as a consequence of traumatic events and is characterised by distressing re-experiencing of parts of the trauma, avoidance of reminders, emotional numbing and hyperarousal. The NICE guidelines for PTSD (2005) recommend trauma-focused psychological therapy as the first-line treatment. A survey of 129 GPs in south

In many mammals, the skin of the rhinarium includes a thick epidermal layer. The skin surface can be smooth but can also display a structure formed of domes, ridges, and polygonal areas: a dermatoglyphic or rhinoglyphic pattern. Each structure consists of an easily visible, large area of the epidermis. The abdominal epidermis may or may not have a dermatoglyphic pattern. The abdominal skin examine

Abstract in UndeterminedAn inventory is described of Rubus sect. Corylifolii from the province of Halland in south-west Swe- den. About 850 localities have been visited and field studies have been combined with chromo- some counting and random amplified polymorphic DNA studies. Ten traditional species have been observed, as well as six local species, two with over70 localities each. The other four

Abstract is not available

Antihaemophilic-factor-A-antibodies, which had spontaneously arisen in 2 patients, were used to develop an immunoradiometric method for measurement of antihaemophilic factor A antigen (VIII:CAg). 13 patients with severe haemophilia A had VIII: CAg below the limit of detection (0.01 U/ml). Patients with moderate and mild haemophilia A either had VIII:CAg roughly equal to factor VIII clotting activi

A semistructured personal interview with 29 female carriers of hemophilia and 23 of their spouses was performed at a median of 3 1/2 years after the first chorionic villus sampling (CVS) and gene analysis. Carriers with a hemophilic father or brother, had high sense of coherence (SOC) scores, and thus would be expected to have good ability to handle the stress of prenatal diagnosis (PD). Prenatal