The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which is associated with both functional biology and the development of a number of disorders, such as Alzheimer and Parkinson diseases. In this Review, we discuss how general physical concepts from the study of phase transitions can be used to illuminate the fundamental mechanisms of amyloid self-assembly. We

We derive the expression of the loop gain in a circuit containing one or more feedback loops, where the transfer functions building the expression are found by means of a few AC analyses on the circuit. No approximations or assumptions on the nature of the loop or of the impedances therein contained are necessary. While hand calculations are certainly possible in the case of simpler circuits, the

BackgroundColorectal cancer (CRC) ranks as the third most frequently occurring cancer and the second leading cause of cancer-related deaths worldwide. In response to the high demand for an effective prevention strategy, chemoprevention, using medications to block the pathogenetic pathways of disease, might be an attractive strategy to offer a more effective option at a low cost. Therefore, we aime

Introduction: Risk evaluation for preeclampsia in early pregnancy allows identification of women at high risk. Prediction models for preeclampsia often include circulating concentrations of placental growth factor (PlGF); however, the models are usually limited to a specific PlGF method of analysis. The aim of this study was to compare three different PlGF methods of analysis in a Swedish cohort t

Denna avhandling behandlar spridning av lätta mesoner i fallet där antalet externa mesoner överstiger fyra (d.v.s. tre eller fler partiklar i initial- eller finaltillståndet), beräknat genom kiral störningsräkning. Detta är både av teoretiskt intresse inom studien av spridningsamplituder, och relevant för system av tre eller fler pioner som simuleras genom gitter-kvantkromodynamik.Introduktionen hThis thesis concerns scattering of light mesons in the case where the number of external particles exceeds four (that is, three or more particles in the initial or final state), calculated using chiral perturbation theory.This is both of theoretical interest in the study of scattering amplitudes, and relevant for systems of three or more pions simulated using lattice quantum chromodynamics.The int

The European Synchrotron Radiation Facility (ESRF), a leading facility in synchrotron science, plays a crucial role in supporting both the local and the international scientific community by providing advanced instrumentation for their research. However, our understanding of the actual reach of the facility and its spatial dynamics remains limited. Thus, a methodology is proposed where author affi

The exhibition and public programme “Systems, Organisms, Symbiosis” reopens again at EIGHT (Polytechniou 8) from 23 September to 22 October 2021. It focuses on active interactions of systems, beings, organisms and narratives as these take place in urban, social and environmental fields. Thinking through notions of mutation, immunity and continuity it explores emergent instituent forms, models of c

Distributed tracing plays a vital role in microservice infrastructure, and learning-based trace analysis has been utilized to detect anomalies within such systems. However, existing approaches for learning-based trace-based anomaly detection face certain limitations. Some assume that trace patterns can be learned solely from normal executions, while others depend on anomaly injection to generate l

BACKGROUND: There is still a profound lack of efficient therapeutic strategies against pancreatic and other periampullary adenocarcinoma. Surgery is seldom possible, leaving palliative chemotherapy the only option for most patients. Chemotherapy treatment is however often accompanied by serious side-effects, and the identification of biomarkers for early prediction of disease and treatment-associa

BackgroundGender stereotypes about women and men have a complementary structure, where women and men are seen as high/low in feminine characteristics and low/high in masculine characteristics. These stereotypes are related to representation within social roles, where beliefs about social role occupation influences which characteristics are associated with women or men. It is not known how people w

Although the nature and definition of populism are a source of considerable disagreement, there seems to be a minimal consensus by now that populism poses a number of threats to liberal democracy, and that public authorities should therefore act in defence of the latter. In searching for appropriate responses, however, most scholars draw from strategies for combatting anti-democratic or extremist

Lichenicolous fungi associated with Xanthoria calcicola s. lat. are studied in southernmost Scandinavia, i.e., Skåne, the southernmost province in Sweden and southern Denmark. Two species, Didymocyrtis slaptoensis and Pyrenochaeta xantho­ riae, are reported as new for the Nordic countries, whereas three species, Didymocyrtis cf. consimilis, Erythricium aurantiacum, and Illosporiopsis christianseni

Theatres of Powerlessness departs from Edit Kaldor’s Inventory of Powerlessness (2013-16), a multi-year theatre project in which hundreds of participants articulated their emergent knowledge about contemporary forms of powerlessness. It is aimed, among others, at student readers in an increasingly diversified educational context, who are learning to develop models of transformative, creative pract

Ölkällarkuppen i München var Hitlers första steg in i rampljuset och nazismens ödesstund. Vi reder ut historien, och uppvaktar 20-åriga Forum för Levande Historia, nu mer relevant än någonsin.I november 1923 stormade Adolf Hitler och hans tyska nationalsocialistiska arbetarparti in på ölkällaren Bürgerbraukeller med pistolen i högsta hugg. Planen, att gripa makten i staden München och sedan marsch

Parallel Life, a theatrical augmentation of city life, a trip through the streets using your phone and your imagination. Have you ever wondered what it would be like to be someone else? To wake up in their skin, to see the world through their eyes? To have lived their childhood, to have experienced sorrows and joys as they have, to dream as they do? Try to imagine being another person and accident

Reflection on the processes, phases and outcomes of the research project The Many and the Form, which explored in different contexts how lived experiences can be articulated in and through live performance. The text brings together the various strands within the research and some of the underlying connections between the different components. It aims to communicate about practices and provide insi

Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in viv

Why theatre? We can’t ask ourselves a more basic question than that and at the same time no question is harder to give an answer to. Why do we make theatre? What purpose does it have or does it even need to have a purpose? Usually, the answers are given by the making of theatre itself – but suddenly we find ourselves in a situation that has shaken up our ways of searching for the answers.

As a research field, social movement and political project, degrowth is a multi-faceted phenomenon. It brings together a range of practices including alternative forms of living and initiatives of various kinds in civil society, business and the state. Yet no comprehensive theory of degrowth transformations has so far been developed. Deep transformations fills this gap. It develops a theory of deg