Parkinson’s disease (PD) is a complex, chronic, and progressive neurodegenerative disease that is characterized by irreversible dopaminergic neuronal loss in the substantia nigra. Alpha-synuclein is normally a synaptic protein that plays a key role in PD due to pathological accumulation as oligomers or fibrils. Clustered alpha-synuclein binds to the Toll-like receptors and activates the microglia,

There is an increasing demand for the application of geophysical methods in engineering projects like bridge construction, mining for building materials and road expansions. Geophysical methods offer reasonable resolution and in cost efficient results as compared with more traditional methods like drilling. Seismic surveying is one of the methods that provide information that can be compared with There is an increasing demand for the application of geophysical methods in engineering projects like bridge construction, mining for building materials and road expansions. Geophysical methods offer reasonable resolution and in cost efficient results as compared with more traditional methods like drilling. Seismic surveying is one of the methods that provide information that can be compared with

Contamination of groundwater resources from industrial sites are a prevalent issue worldwide. Characteristic of contaminated site investigations is small site scale and variability of ground conditions that necessitate extensive invasive methods. Invasive methods are costly and therefore pursuit of applicable less costly non-invasive methods to characterise the site and develop a robust ConceptualContamination of groundwater resources from industrial sites are a prevalent issue worldwide. Characteristic of contaminated site investigations is small site scale and variability of ground conditions that necessitate extensive invasive methods. Invasive methods are costly and therefore pursuit of applicable less costly non-invasive methods to characterise the site and develop a robust Conceptual

Multi-component reflection methods have gained acceptance for near surface mapping during recent years. Two case studies from Denmark employing shear wave reflection at different survey scales are presented. The first case study is a small site scale investigation to image the near surface lithology of a contaminated site. Here the S-wave reflection mapping was employed to update the Conceptual SiMulti-component reflection methods have gained acceptance for near surface mapping during recent years. Two case studies from Denmark employing shear wave reflection at different survey scales are presented. The first case study is a small site scale investigation to image the near surface lithology of a contaminated site. Here the S-wave reflection mapping was employed to update the Conceptual Si

Summary: This study describes that low bone density is prevalent in premenopausal Saudi women, especially women of normal weight and vitamin D deficiency. Although BMD is higher in obese young women, this may not be beneficial later in life in conjunction with persistent vitamin D deficiency. Introduction: Not attaining peak bone mass is one crucial factor contributing to the risk of developing os

Geophysical methods are prone to fail in an urban environment as all sources of noise are present in cities. The Fælledparken Park, a large open space area in Copenhagen, Denmark is not an exception. However, an extension of the metro along sections of high variability on the surface of a limestone surface motivated the use of geoelectrics as complement to seismic methods. The site conditions haveGeophysical methods are prone to fail in an urban environment as all sources of noise are present in cities. The Fælledparken Park, a large open space area in Copenhagen, Denmark is not an exception. However, an extension of the metro along sections of high variability on the surface of a limestone surface motivated the use of geoelectrics as complement to seismic methods. The site conditions have

This work presents examples from processing and interpretation of 2576 km of SkyTEM data in the Ringsted-Suså groundwater mapping area located southeast of Denmark. The mapping area is approx. 422 km2 and includes approx. 75,000 SkyTEM soundings. Additionally, diverse ground based geophysical data (>260 km Multi-Electrode Profiling (MEP), > 130 km Pulled-Array Continuous Electrical Soundings (PACEThis work presents examples from processing and interpretation of 2576 km of SkyTEM data in the Ringsted-Suså groundwater mapping area located southeast of Denmark. The mapping area is approx. 422 km2 and includes approx. 75,000 SkyTEM soundings. Additionally, diverse ground based geophysical data (>260 km Multi-Electrode Profiling (MEP), > 130 km Pulled-Array Continuous Electrical Soundings (PACE

To provide a complete portrayal of the multiple factors negatively impacting insects in agricultural landscapes it is necessary to assess the concurrent incidence, magnitude, and interactions among multiple stressors over substantial biogeographical scales. Trans-national ecological field investigations with wide-ranging stakeholders typically encounter numerous challenges during the design planni

The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact cooperatively with target proteins and designed ligands, with important implications for drug discovery. Here, we used nuclear magnetic resonance (NMR)

We revisit our rope model for string fragmentation that has been shown to give a reasonable description of strangeness and baryon enhancement in high-multiplicity pp events at the LHC. A key feature of the model is that the enhancement is driven by the increased string tension due to strings overlapping in dense systems. By introducing an improved space–time picture for the overlap between fragmen

A new landstreamer system has been developed that provides high resolution imaging from near surface to medium depths. The system is comprised of a combination three-component array to acquire SH data for near surface and a single component array to acquire typical P-wave data at depth. The first application of the system is being carried out for a groundwater mapping project where detailed knowleA new landstreamer system has been developed that provides high resolution imaging from near surface to medium depths. The system is comprised of a combination three-component array to acquire SH data for near surface and a single component array to acquire typical P-wave data at depth. The first application of the system is being carried out for a groundwater mapping project where detailed knowle

Purpose: Visual functioning evaluated by the Catquest-9SF questionnaire has shown to be a valid measure for assessing a patient's prioritization for cataract surgery. This study adapted Catquest-9SF for visual function outcomes post uni-lateral cataract surgery or bi-lateral cataract surgery. Methods: Visual functioning was assessed before and after uni-lateral or bi-lateral cataract surgery using

Seismic refraction imaging is a technique that has seen an increase of applications in engineering during recent years. In the work presented here a case of refraction tomography in the city of Copenhagen is discussed. The survey included two modalities; 1. a surface survey where 13.9 kilometers of crooked lines along segments of the planned underground metro were mapped, 2. borehole “walk-away” sSeismic refraction imaging is a technique that has seen an increase of applications in engineering during recent years. In the work presented here a case of refraction tomography in the city of Copenhagen is discussed. The survey included two modalities; 1. a surface survey where 13.9 kilometers of crooked lines along segments of the planned underground metro were mapped, 2. borehole “walk-away” s

This work presents a case where a combination of electromagnetics (EM61), refraction seismic surveys and a geotechnical survey allowed a detailed mapping of the near surface at a soil depot.This work presents a case where a combination of electromagnetics (EM61), refraction seismic surveys and a geotechnical survey allowed a detailed mapping of the near surface at a soil depot. Such results together with knowledge of the glacial overburden and groundwater potential enabled accurate determination of digging depth within the area, and thereby optimizing extension of the soil depot. The

We study the role of intermediate excitations of Rydberg states as an example of Kuchiev's "atomic antenna"in above-threshold ionization of xenon, in particular their effect on the coherence between the spin-orbit-split states of the ion. We focus on the case of a laser frequency close to resonant with the spin-orbit splitting, where a symmetry (parity) argument would preclude any coherence being

Fires are a major hazard resulting in high monetary costs, personal suffering, and irreplaceable losses. The consequences of a fire can be mitigated by early detection systems which increase the potential for successful intervention. The number of false alarms in current systems can for some applications be very high, but could be reduced by increasing the reliability of the detection system by us

This paper proposes a critical analysis of the innovative jurisprudential approaches taken by the Inter-American Court of Human Rights in integrating the content and scope of protection of the human rights of children, in the context of migration processes. How might one provide an effective protection to unaccompanied children that enter irregularly into the territory of a given country, when the