OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age

BACKGROUND: Although parasitism has been acknowledged as an important selective force in the evolution of host life histories, studies of fitness effects of parasites in wild populations have yielded mixed results. One reason for this may be that most studies only test for a linear relationship between infection intensity and host fitness. If resistance to parasites is costly, however, fitness may

Recent findings have shown that the physiological functions of the hormone aldosterone go far beyond its well-known role in blood-pressure regulation and salt/water homeostasis. Aldosterone is for example involved in the regulation of inflammation, and also binds directly to mineralocorticoid receptors in specific brain regions. Interestingly, depressive symptoms appear to correlate with alteratio

Steep-slope devices, such as tunnel field-effect transistors (TFETs), have recently gained interest due to their potential for low power operation at room temperature. The devices are based on inter-band tunneling which could limit the on-current since the charge carriers must tunnel through a barrier to traverse the device. The InAs/GaSb heterostructure forms a broken type II band alignment wh

tmospherically important data are gained from cloud condensation nucleus counter (CCNC) analysis of aerosols that are particle mobility separated using differential mobility analysers (I)MA). We present relaxed step functions that can be fitted to these data to obtain critical diameters or critical supersaturations. The step functions are based on the DMA transfer function. We treat the case with

The jet fragmentation function and transverse profile for jets with 25 GeV < p(Tjet) < 500 GeV and |eta(jet)| < 1.2 produced in proton-proton collisions with a center-of-mass energy of 7 TeV are presented. The measurement is performed using data with an integrated luminosity of 36 pb(-1). Jets are reconstructed and their momentum measured using calorimetric information. The momenta of the charged

Patients with Ménière's disease and cochlear hydrops show fluctuating low-frequency hearing loss (FLFHL). At present these changes are followed as patients' subjective reports and occasional measurements. Consecutive long-term measurements should provide more comprehensive information on the hearing fluctuations than the occasional audiogram used today and constitute an approach to quantify the fl

Aims Inflammatory markers are established risk factors for atrial fibrillation (AF), but the role of autoimmune diseases is unknown. The aim of the study was to examine the association between coeliac disease (CD) and AF in a large cohort of patients with biopsy-verified CD. Methods and results We identified 28 637 patients with CD through biopsy reports (defined as Marsh 3: villous atrophy) from

The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such

The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on the monitoring, management, and treatment of kidney transplant recipients is intended to assist the practitioner caring for adults and children after kidney transplantation. The guideline development process followed an evidence-based approach, and management recommendations are based on systematic reviews of

Co-selection for antibiotic tolerance in Cu polluted soils was studied in a laboratory experiment. Pollution Induced Community Tolerance (PICT) of the bacterial community was estimated using leucine incorporation. PICT was found in Cu polluted soils to tetracycline (>= 8 mmol Cu kg(-1)), tylosin (>= 16 mmol Cu kg(-1)) and vancomycin (>= 16 mmol Cu kg(-1)). PICT to the antibiotics was found at high

Autoignition and stabilization of n-Dodecane spray combustion under diesel engine like conditions are investigated using large eddy simulation and detailed chemical kinetics. The Spray A cases of Engine Combustion Network (ECN) with ambient temperatures of 900 K and 1000 K are considered. Two-stage ignition behavior is predicted in the studied conditions. It is found that the first-stage ignition

The overall aim of this thesis was to describe the experiences of obstetricians and parents and the attitudes of midwives in relation to critical situations during pregnancy and birth. The data collection (Paper I and II) started in year 2000 with interviews with obstetricians (n=14) concerning the meaning of being in ethically difficult situations. During 2002 to 2004 interviews with parents (n=2

Decentralized control of bilateral teleoperation systems with time delays is considered within the H2 optimization framework. We demonstrate that the problem is quadratically invariant and can be split into two independent model matching optimizations with partial multiplicative delay. The recent loop shifting techniques for delayed systems control are used then to find a complete analytical solut

The ruptured anterior cruciate ligament (ACL) leads to immediate symptoms that severely affect the individual and receives great attention among the scientific community, yet there is still no consensus on the optional form of treatment. An ACL injury is also a well known high risk factor for the development of knee osteoarthritis (OA) some decades later. Knee OA development after an ACL injury is

Anthracyclines and taxanes are active cytotoxic drugs in the treatment of early metastatic breast cancer. It is yet unclear whether addition of capecitabine to the combination of these drugs improves the treatment outcome. Patients with advanced breast cancer were randomized to first-line chemotherapy with a combination of epirubicin (Farmorubicin(A (R))) and paclitaxel (Taxol(A (R))) alone (ET) o