MOTIVATION: Transcription factors (TFs) are key regulators of gene expression, and can activate or repress multiple target genes, forming regulatory units, or regulons. Understanding downstream effects of these regulators includes evaluating how TFs cooperate or compete within regulatory networks. Here we present RTNduals, an R/Bioconductor package that implements a general method for analyzing pa

Single-shot absorption measurements have been performed using the multi-keV x rays generated by a laser-wakefield accelerator. A 200 TW laser was used to drive a laser-wakefield accelerator in a mode which produced broadband electron beams with a maximum energy above 1 GeV and a broad divergence of ≈15 mrad FWHM. Betatron oscillations of these electrons generated 1.2±0.2×106 photons/eV in the 5 ke

The global rise in obesity and steady decline in sperm quality are two alarming trends that have emerged during recent decades. In parallel, evidence from model organisms shows that paternal diet can affect offspring metabolic health in a process involving sperm tRNA-derived small RNA (tsRNA). Here, we report that human sperm are acutely sensitive to nutrient flux, both in terms of sperm motility

Objective: Clinical observations over time of adults with growth hormone (GH) deficiency (GHD) have indicated a shift in patient characteristics at diagnosis. The objective of this study was to compare baseline characteristics of patients diagnosed with adult-onset GHD naive to GH replacement during t hree study periods (1994-1999 (P1), 2000-2004 (P2), and 2005-2012 (P3)) using the KIMS (Pfizer's

Aim: The aim of this study was to describe team leaders' experiences of facilitators and barriers of leadership in specialist palliative home care teams. Background: For effective teamwork in specialist palliative care, leadership is crucial; however, defining and agreeing on what leadership comprises may be challenging. In palliative care, teamwork is recognized as imperative for multiprofessiona

Many cellular proteins are methylated on lysine residues and this has been most intensively studied for histone proteins. Lysine methylations on non-histone proteins are also frequent, but in most cases the functional significance of the methylation event, as well as the identity of the responsible lysine (K) specific methyltransferase (KMT), remain unknown. Several recently discovered KMTs belong

The “Kioskisation” team visited four Eastern European cities to look into the kiosk situation in the microrayon. The results are kiosk trail maps, kiosk collectors’ microrayon, a manual on how to start a kiosk, a documentary film (all in four languages) and a transportable kiosk cinema.

Electric road systems (ERS) are technologies that allow to charge electric vehicles (EVs) while they are driving. A large scale implementation of ERS would allow to significantly reduce the installed battery capacity on board the vehicles, which consequently reduces their weight and cost. Due to geographical, practical and economic constraints the ERS is not expected to cover the full extension of

OBJECTIVES:To report the initial experience of an international group of investigators in identifying mutations in the BRCA1 breast and ovarian cancer susceptibility gene, to assess the spectrum of such mutations in samples from patients with different family histories of cancer, and to determine the frequency of recurrent mutations.DESIGN:Nine laboratories in North America and the United Kingdom

Although self-harm is a common behavior and exists in many contexts, previous research on tolerance and attitudes has focused primarily on health care providers. Less is known about tolerance toward self-harm in the general population. To the best of our knowledge, there is currently no scale assessing public tolerance toward self-harm. For this purpose, a brief scale was constructed and tested fo

This article examines the possibility for conducting an empirical analysis of a system of industrial relations using Luhmann’s theory on autopoietic systems as a framework of analysis, but aligning that analysis with the aspirations of critical theory. The article provides a methodological contribution and based on the dual understanding of the concept of values as containing both a positivistic a

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. T

This chapter discusses the current problems and future prospects of the euro area. The author argues that the problem for the euro area is not the return of the nation-state, but that the nation-states never disappeared. A common currency requires common economic policies, which is largely lacking in the euro area. As a result, large economic and social imbalances have emerged. The chapter examine

The preliminary results of a survey of ancient Hermione (epichoric Hermion) are presented in this paper. The survey was conducted during three short campaigns over the period 2015–2017, and focused on the urban layout and development of the ancient city. Because the ancient city area more or less coincides with modern Ermioni, the investigation was mainly restricted to the documentation and analys