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A core drilling through Cambrian strata at Almbacken, Scania, S. Sweden: trilobites and stratigraphical assessment

A core drilling at Almbacken in the village Sodra Sandby, Scania, southern Sweden, penetrated a c. 30 in thick succession of upper lower Cambrian and middle Cambrian strata. Only the uppermost part of the lower Cambrian (Gislov Formation) was recovered, comprising c. 1.50 m of unfossiliferous siltstones and a thin limestone bed at the base of the core. The core contains the most complete middle Ca

Experiences of stigma among people with severe mental illness. Reliability, acceptability and construct validity of the Swedish versions of two stigma scales measuring devaluation/discrimination and rejection experiences

Stigma has been identified as one of the most important obstacles for a successful integration of people with mental illness into the society. Research about stigma has shown negative attitudes among the public towards people with mental illness. Studies so far have, however, put little emphasis on how these negative attitudes are perceived by the mentally ill persons. The aim of the present study

OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis

Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee,

Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells

Human cathelicidin antimicrobial protein hCAP18/LL-37 is an effector molecule of the nonspecific innate immune system. hCAP18/LL-37 is present in leukocytes and is expressed in skin and other epithelia, where it is upregulated in association with inflammation and injury. In addition, antimicrobial proteins including cathelicidins have been proposed to play a role in the nonspecific defense against

Floral volatiles controlling ant behaviour

P>1. Ants show complex interactions with plants, both facultative and mutualistic, ranging from grazers through seed predators and dispersers to herders of some herbivores and guards against others. But ants are rarely pollinators, and their visits to flowers may be detrimental to plant fitness. 2. Plants therefore have various strategies to control ant distributions, and restrict them to foliage

Unprecedented enantioselectivity in a cluster-based catalytic system

Catalytic systems based on the clusters [H4RU4(CO)(10)-{mu-1,2-(P-P)}] and [H4RU4(CO)(10){1,1-(P-P)}] (P-P = (R)-(R)-Ph(2)PPhFcCHCH(3)PR(2); Fc = ferrocenyl; R = 3,5-CF3Ph (W001), Ph (W002)) have been used successfully in asymmetric hydrogenation of prochiral alpha-unsaturated carboxylic acids under mild conditions. Enantiomeric excesses of 42-92% and conversion rates in excess of 99% were observe

Evaluation of quadrivalent HPV 6/11/16/18 vaccine efficacy against cervical and anogenital disease in subjects with serological evidence of prior vaccine type HPV infection

Objective: In the quadrivalent (types 6/11/16/18) HPV vaccine (GARDASIL (R)/SILGARD (R)) clinical program, 73% of women aged 16-26 were naive to all vaccine HPV types. In these women, prophylactic administration of the vaccine was highly effective in preventing HPV 6/11/16/18-related cervical disease. Of the remaining women, 15% of had evidence of past infection with one or more vaccine HPV types

Elemental sulfur: Toxicity in vivo and in vitro to bacterial luciferase, in vitro yeast alcohol dehydrogenase, and bovine liver catalase

The aim of this research was to analyze the effects and the modes of action of elemental sulfur (So) in bioluminescence and respiration of Vibrio fischeri cells and the enzymes crude luciferase, pure catalase, and alcohol dehydrogenase (ADH). Metallic copper removed sulfur and reduced the toxicity of acetone extracts of sediment samples analyzed in the bioluminescence test. The sulfur inhibition o

Life satisfaction in 6 European countries: The relationship to health, self-esteem, and social and financial resources among people (aged 65-89) with reduced functional capacity

The aim of this study was to investigate how overall health, participation in physical activities, self-esteem, and social and financial resources are related to life satisfaction among people aged 65 and older with reduced activities of daily living (ADL) capacity in 6 European countries. A subsample of the European Study of Adults’ Well-Being (ESAW), consisting of 2,195 people with reduced ADL c

Diurnal profiles of salivary cortisol on workdays among construction workers versus white-collar workers

Objectives The aim of the present study was to test whether construction workers, who are known to have a relatively higher risk of cardiovascular disease (CVD), had higher concentrations of cortisol in saliva and a lower relative variability when compared with white-collar workers. Methods Data from two groups of male construction workers with physically demanding job assignments, with either reg

An investigation of the peroxidase activity of Vitreoscilla hemoglobin

In order to investigate the ability of the Vitreoscilla hemoglobin (VHb) to act as a peroxidase, the protein was overexpressed in Escerichia coli and purified using a 6xHis-tag. The peroxidase activity of VHb was studied using 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferrocene carboxylic acid (FcCOOH) dopamine and L-dopa as substrates. The effects of external agents such as pH

Socioeconomic positoon and the risk of gastric and overphageal cancer in the European Prospective into Cancer and Nutrition (EPIC-EURGAST)

Objectives To evaluate the association of socioeconomic position with adenocarcinoma of the oesophagus and stomach. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort comprises about 520000 participants mostly aged 35-70 years. Information on diet and lifestyle was collected at recruitment. After an average follow-up of 6.5 years, 268 cases with adenocarcinoma o

An academic ECG core lab perspective of the FDA initiative for digital ECG capture and data management in large-scale clinical trials

Maximal utility of accessible data is attractive to all partners in clinical research, whether it directly improves patient care or more accurately allows identification of the safety and efficacy of a new drug or procedure. The Food and Drug Administration (FDA) has presented a guideline draft addressing digitization of electrocardiogram (ECG) data in clinical trials to improve the standards for

Is there a relationship between balance, gait performance and muscular strength in 75-year-old women?

OBJECTIVE: To see if there is a relationship between clinical and laboratory tests of balance, muscular strength and gait in elderly women. DESIGN: A randomized population-based study. SETTINGS: Malmo, Sweden. METHODS: We investigated balance with a simple test of standing on one leg, as well as a computerized balance platform. Muscular strength was tested by computerized dynamometer. Extension an

Transcending Tradition : Towards a Critical Theology of the Spirit

In recent years, the renewed presence of religion in the European societies has inspired a number of intellectuals on a popular as well as academic level to critically engage with religion. The aim of this article is to give a contribution to this debate. In contrast to the rather reductive and objectifying accounts of religion offered in much of the contemporary critique, I argue that a relevant

Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height

Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common human diseases and other complex traits in which multiple genetic and environmental factors interact to influence disease risk. We hypothesized that a highly heritable complex trait, in which the contrib