We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol

Background and Objectives: Hand eczema is a chronic disease with negative impact on quality of life (QoL). In this study, QoL in hand eczema patients is assessed and related to age, sex, severity, and diagnostic subgroups. Methods: A total of 416 patients with hand eczema from 10 European patch test clinics participated in the study. Data on QoL were obtained from a self-administered questionnaire

Recent investigations have shown neuropeptide Y (NPY) to be present in the rabbit maxillary sinus, and NPY is known to be released upon sympathetic nerve stimulation. To study, in vivo, the effect on mucociliary activity and blood flow, NPY 1-36 and some of its analogues were injected intra-arterially. The effects of the Y1/Y2 agonist NPY 1-36 was compared with the ones of the Y2 agonist NPY 16-36

This article describes and evaluates algorithms and their hardware architectures for binary morphological erosion and dilation. In particular, a fast stall-free low-complexity architecture is proposed that takes advantage of the morphological duality principle and structuring element (SE) decomposition. The design is intended to be used as a hardware accelerator in real-time embedded processing ap

Intake of fruits and vegetables is thought to protect against the development of lung cancer. However, some recent cohort and case-control studies have shown no protective effect. We have assessed the relation between fruit and vegetable intake and lung cancer incidence in the large prospective investigation on diet and cancer, the European Prospective Investigation Into Cancer and Nutrition (EPIC

Clinicians currently use simple cut-points, such as serum prostate-specific antigen (PSA) >= 4 ng/ml, to decide whether to recommend further work-up for prostate cancer (PCa). As an alternative strategy, we evaluated multivariable models giving probabilities of a PCa diagnosis based on PSA and several circulating novel biomarkers. We measured total PSA, free PSA (fPSA), fPSA subfractions (single-c

This paper presents a computer-based decision support system for automated interpretation of diagnostic heart images (called WeAidU), which is made available via the Internet. The system is based on image processing techniques, artificial neural networks (ANNs) and large well-validated medical databases. We present results using artificial neural networks, and compare with two other classification

This paper proposes a new class of hybrid VLSI architectures for survivor path processing to be used in Viterbi decoders. The architecture combines the benefits of register exchange and trace-forward algorithms, that is, low memory requirement and latency versus implementation efficiency. Based on a structural comparison, it becomes evident that the architecture can be efficiently applied to codes

We report here, for the first time, the occurrence of the trilobite Odontopleura (Odontopleura) ovata Emmrich, 1839 from Scandinavia. The specimens came in light during a study of middle Silurian calcareous mudstone formed in offshore settings of the Baltic Basin (Grotlingbo-1 core, south-eastern Gotland). Intrabasinal correlation shows that the taxon had a brief mass occurrence during the latest

We studied the influence of shape and secondary, or intercellular, organization on the absorption and scattering properties of red blood cells to determine whether these properties are of any practical significance for optical evaluation of whole blood and its constituents. A series of measurements of transmittance and reflectance of light from bovine blood in a flow cuvette was conducted with a 6

The migratory orientation of sanderlings (Calidris alba) was investigated with cage experiments during the spring migration in southwest Iceland. Sanderlings were exposed to 90 degrees counterclockwise-shifted magnetic fields under both clear skies and natural overcast. Clear sky control tests resulted in a northerly mean direction, in agreement with predictions based on ringing recovery data and

Amyloidogenic proteins like cystatin C and prion proteins have been shown to form dimers by exchange of subdomains of the monomeric proteins. This process, called "three-dimensional domain swapping," has also been suggested to play a part in the generation of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic, and persons carrying the corresponding gene suffer fro

BACKGROUND: In the last 15 y there has been a tremendous increase in the number of studies on pediatric obesity looking at epidemiology, health-related risks, etiology, methodology and treatment. During the early 1990s, the European Childhood Obesity Group (ECOG) was born as a group of scientists' expert in the field of pediatric obesity. ECOG this year celebrates the approach to early maturity wi

It was recently suggested that the error with respect to experimental data in nuclear mass calculations is due to the presence of chaotic motion. The theory was tested by analyzing the typical error size. A more sensitive quantity, the correlations of the mass error between neighboring nuclei, is studied here. The results provide further support to this physical interpretation.

Important constituents of extracellular matrix are collagen, fibronectin, hyaluronan, and various types of proteoglycans, such as versican, perlecan, decorin, and biglycan. Remodeling of extracellular matrix occurs continuously and is affected by various cytokines. The aim of this study was to investigate how interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), separately and

Total hip replacement (THR) is a common and costly procedure. The number of THR is expected to increase over the coming years. Two pathways of postoperative treatment were compared in a randomized study. Fifty patients from two hospitals were randomized into a study group (SG) of 27 patients receiving preoperative and postoperative education programs, as well as home visits from an outpatient team