Cyclase-associated proteins (CAPs) are evolutionary conserved G-actin-binding proteins that regulate microfilament turnover. CAPs have a modular structure consisting of an N-terminal adenylate cyclase binding domain, a central proline-rich segment, and a C-terminal actin binding domain. Protozoan parasites of the phylum Apicomplexa, such as Cryptosporidium and the malaria parasite Plasmodium, expr

The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-3. PARP-3 is not activated upon binding to DNA and is a mono-ADP-ribosylase, in contrast to PARP-1 a

Opportunistic mobile predators can adapt their behaviour to specific foraging scenarios, allowing them to target diverse prey resources. An interesting example is the harbour porpoise (Phocoena phocoena), a marine mammal with a huge energy demand feeding on a large variety of fish, squid and shrimps. Little is known about the foraging behaviour of harbour porpoises, as observations of wild specime

Little is known about the aetiology of thymoma. This study aims to identify medical risk factors for thymoma as a systematic approach to new hypotheses on the aetiology of this disease. A European multi-centre case–control study was conducted from 1995 to 1997, including incident cases aged 35–69 years with thymoma. Altogether, we accepted 85 cases and 3350 controls, of which we interviewed 77 cas

Objective: To systematically evaluate which lesion-based imaging features and methods allow for the best statistical prediction of poststroke deficits across independent datasets. Methods: We utilized imaging and clinical data from three independent datasets of patients experiencing acute stroke (N1 = 109, N2 = 638, N3 = 794) to statistically predict acute stroke severity (NIHSS) based on lesion v

Knowledge management is pivotal in innovation using mechanisms to facilitate knowledge exchange and learning among competitive tourism organisations and destinations. Nevertheless, both the tourism industry and its scholars have been slow to embrace the field leaving it relatively underdeveloped. Knowledge management, as a sequential process of capturing, developing, sharing, and leveraging from o

Human monocarboxylate transporters (hMCTs) belong to the solute carrier 16 (SLC16) family of proteins and are responsible for the bi-directional transport of various metabolites, including monocarboxylates, hormones, and aromatic amino acids. Hence, the metabolic role of hMCTs is undisputable, as they are directly involved in providing nutrients for oxidation and gluconeogenesis as well as partici

Tourism is consistently affected by a change. Whether it be economic, social, and cultural, or whether it be technological and environmental, which are the focus of much contemporary tourism scholarship. Furthermore, change occurs at different scales and is uneven over space and time. Therefore, while all change is experienced locally, global overviews such as that provided in this book can only p

Har du någonsin funderat på varför såpbubblor tar den form de gör? Mer specifikt, tänk dig att du doppar ner ett böjbart ihopknutet snöre i såpa så att ett tunnt lager formas. Om du håller snöret i en cirkel så kommer cirkeln fyllas, det är kanske inget konstigt, men vad händer med såpan om du börjar böja på snöret? Den yta som bildas är ett exempel på vad som i matematiken kallas för en minimal yWe introduce the basic theory of currents as continuous linear functionals on compactly supported smooth differential forms. By using slicing and metric-space-valued functions of bounded variation, we prove that the subspace of integer-multiplicity rectifiable currents with locally finite mass enjoy a certain sequential compactness property. This compactness theorem is then used to prove the exist

To steer the economy towards a low-carbon future and mitigate climate change, the European Union Emissions Trading System (EU ETS) has been established at the European level. It operates through a cap-and-trade mechanism and currently regulates around 40% of the EU’s CO2 emissions. However, due to regional differences in the industry mix and the spatial concentration of regulated industrial instal

Introduction: Digital options for osteoarthritis (OA) treatment are increasingly available with high patient satisfaction and acceptability. Little is, however, known about physical therapists’ (PT) perception of this treatment modality. Objective: To investigate PT’s experience of delivering digital treatment for hip and knee OA using a smart-phone application. Method: Nine PTs (mean age 36 years

How have the momentous policy shifts that followed the death of Mao Zedong changed families in China? What are the effects of the decollectivization of agriculture, the encouragement of limited private enterprise, and the world's strictest birth-control policy? Eleven sociologists and anthropologists explore these and other questions in this path-breaking volume. The essays concern both urban and

The Swedish Campaign for Nuclear Disarmament (SCND) fought the military’s plans to acquire Swedish nuclear weapons and protested the nuclear arms race, 1961–1967. This article presents SCND’s ideological orientation by focusing on temporalities. SCND saw the Second World War as a decisive event and tried to avert a crisis and a dystopia by manifesting remembrance of past nuclear detonations, and b

Biochemical analyses of blood can decipher physiological conditions of living animals and unravel mechanistic underpinnings of life-history strategies and trade-offs. Yet, researchers in ecology and evolution often face constraints in which methods to apply, not least due to blood volume restrictions or field settings. Here, we test the suitability of a portable biochemical analyser (Zoetis VetSca