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Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services
Background: The ongoing pandemic is having a collateral health effect on delivery of surgical care to millions of patients. Very little is known about pandemic management and effects on other services, including delivery of surgery. Methods: This was a scoping review of all available literature pertaining to COVID-19 and surgery, using electronic databases, society websites, webinars and preprint
Rational molecular design of anion exchange membranes functionalized with alicyclic quaternary ammonium cations
High alkaline stability is critical for polymeric anion exchange membranes (AEMs) and ionomers for use in alkaline electrochemical energy conversion and storage devices such as fuel cells, electrolyzer cells and advanced batteries. Here, we have prepared and studied ether-free polyfluorenes tethered with N,N-dimethylpiperidinium (DMP) and 6-azonia-spiro[5.5]undecane (ASU) cations, respectively, at
Public sector growth in the British Cape Colony: Evidence from new data on expenditure and foreign debt, 1830-1910
AbstractThe public expenditure shifts that took place following the discovery of diamonds and gold during the second half of the nineteenth century had far-reaching consequences for southern Africa’s development. Using new data for public expenditure and foreign debt in the Cape Colony and evidence from Cape parliamentary budget debates, we trace and explain the growth of the publicsector. We find
Characterizing gaze position signals and synthesizing noise during fixations in eye-tracking data
The magnitude of variation in the gaze position signals recorded by an eye tracker, also known as its precision, is an important aspect of an eye tracker’s data quality. However, data quality of eye-tracking signals is still poorly understood. In this paper, we therefore investigate the following: (1) How do the various available measures characterizing eye-tracking data during fixation relate to
Mnemonic discrimination of object and context is differentially associated with mental health
Episodic memories are formed by hippocampal binding of the "what" and "where" features of everyday events. The hippocampus minimizes interference between related similar episodic memories by pattern separation. Stress and psychopathology are associated with lowered pattern separation. While current behavioral paradigms typically use correct rejections of single object or context lures rather than Episodic memories are formed by hippocampal binding of the "what" and "where" features of everyday events. The hippocampus minimizes interference between related similar episodic memories by pattern separation. Stress and psychopathology are associated with lowered pattern separation. While current behavioral paradigms typically use correct rejections of single object or context lures rather than
Interactive proteogenomic exploration of response to Fusarium head blight in oat varieties with different resistance
Fusarium species are cereal pathogens that cause the Fusarium Head Blight (FHB) disease. FHB can reduce yield, cause mycotoxin accumulation in the grain and reduce germination efficiency of the harvested seeds. Understanding the biochemical interactions between the host plants and the pathogen is crucial for controlling the disease and for the development of cultivars with improved tolerance to FH
Proteomics of PTI and Two ETI Immune Reactions in Potato Leaves
Plants have a variety of ways to defend themselves against pathogens. A commonly used model of the plant immune system is divided into a general response triggered by pathogen-associated molecular patterns (PAMPs), and a specific response triggered by effectors. The first type of response is known as PAMP triggered immunity (PTI), and the second is known as effector-triggered immunity (ETI). To ob
Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation
Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin gene. The expanded polyglutamine (polyQ) repeat of the encoded protein leads to protein misfolding and aggregation, resulting in increased neuronal cell death. DNAJ co-chaperones play a crucial role in transferring misfolded/unfolded proteins to HSP70 chaperones, which play an essential role for protein folding. Here, we
The influence of soil warming on organic carbon sequestration of arbuscular mycorrhizal fungi in a sub-arctic grassland
A substantial portion of grassland photosynthates is allocated belowground to arbuscular mycorrhizal fungi (AMF), but controversy remains about whether this carbon (C) contributes to soil organic carbon (SOC) under warming. The goal of this study was to investigate how AMF biomass and C sequestered by AMF (CNew) are influenced by soil warming. We estimated the AMF biomass and CNew, assumed to be m
The consequences of saline irrigation treatments on soil physicochemical characteristics
When saline water is used to irrigate crops in arid environments, appropriate irrigation management should be applied to avoid negatively impacting soil characteristics. In this study, the effects of irrigating date palms with saline water (2.24 g l−1) on soil physicochemical characteristics such as the electrical conductivity (ECe), the pH of the saturated soil paste (pHe), the concentrations of
Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency
3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is considered to be a rare cause of congenital microcephaly, infantile onset of intractable seizures and severe psychomotor retardation. Here, we report for the first time a very mild form of genetically confirmed 3-PGDH deficiency in two siblings with juvenile onset of absence seizures and mild developmental delay. Amino acid analysis showed se
Fast-Response Sprinkler Technology : Hsiang-Cheng Kung, Gunnar Heskestad, Robert Bill, Roger Allard: The 2019 Phillip J. DiNenno Prize
The National Fire Protection Association has recognized fast-response sprinkler technology, developed and promulgated by Factory Mutual Research Corporation (FMRC, now FM Global), with its 2019 Phillip J. DiNenno Prize. This technology was the result of three innovative efforts that produced Response-Time Index (RTI), quick-response (QR) residential sprinklers, and the Early Suppression, Fast Resp
Study of wear mechanisms of cemented carbide tools during machining of single-phase niobium
In particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting tooIn particle accelerator facilities, single-phase niobium is used in superconducting accelerator components. Machining induced surface quality of such components is strongly connected to the functionality of accelerators. In this study, tool wear development and its influence on the surface quality of Nb workpiece have been investigated in longitudinal turning. Uncoated cemented carbide cutting too
Impact of coordinate rotation on eddy covariance fluxes at complex sites
The choice of coordinate system to calculate eddy covariance fluxes becomes particularly relevant at complex measurement sites. The traditional way is to perform double rotation (DR) of the coordinate system i.e., to calculate turbulent fluxes in a coordinate system that is aligned with the flow streamlines within the flux averaging period (e.g., Kaimal and Finnigan, 1994). The second approach, th
Effects of change of density stratification due to Isahaya Sea-Dyke on the fate of anoxic water in the Ariake Sea
In this study, we aim to investigate the possibility that the construction of the Isahaya Sea-Dyke significantly causes anoxic water development in the bottom layer in the Ariake Sea, Japan. We numerically compared the vertical distribution of dissolved oxygen (DO) in the water column between two cases with the dyke and without it. As a result of this research, the followings are clarified: 1) DO
Covalent Functionalization of Bioengineered Polyhydroxyalkanoate Spheres Directed by Specific Protein-Protein Interactions
Bioengineered polyhydroxyalkanoate (PHA) spheres assembled in engineered bacteria are showing promising potential in protein immobilization for high-value applications. Here, we have designed innovative streamlined approaches to add functional proteins from complex mixtures (e.g., without prior purification) to bioengineered PHA spheres directly harnessing the specificity of the SpyTag/SpyCatcher
How violence happens (or not)
Objective: Recent studies show that violence is difficult to accomplish and only occurs under particular situational circumstances—but does this also apply to protests in authoritarian regimes? This article investigates the microdynamics of violence during the antiregime protests in Tunisia, Syria, and Bahrain. Method: The argument is based on visual data analysis of video footage of violent and n
Routing using Safe Reinforcement Learning
The ever increasing number of connected devices has lead to a metoric rise in the amount data to be processed. This has caused computation to be moved to the edge of the cloud increasing the importance of efficiency in the whole of cloud. The use of this fog computing for time-critical control applications is on the rise and requires robust guarantees on transmission times of the packets in the ne
Decreasing organic carbon bioreactivity in European rivers
European rivers experience increased loading of total organic carbon (TOC) from terrestrial sources due to factors involving changes in land use, climate and soil acidity. However, little is known about how increased TOC is linked to changes in the bioreactivity of organic matter in these rivers on a continental scale. We compiled paired measurements of TOC and biological oxygen demand in 5‐day 20