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Accuracy and Precision of Radioactivity Quantification in Nuclear Medicine Images

The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such

Kreditbedömning och rekonstruktion av företag i tider av makroekonomisk turbulens: Fallen General Motors och Ford

Behovet av modeller för att förutsäga risken för att ett företag inte skall kunna fullfölja sin skuldtjänst har aktualiserats av de nya Baselreglerna, som kräver fördjupad kvantitativ kreditvärdering, och av den pågående världsomspännande ekonomiska krisen. Ett antal alternativa modeller för att förutsäga kommande kreditsvårigheter och en eventuell konkurs existerar. Flera inkluderar makroekonomis

Beyond the basal ganglia

Huntington’s disease (HD) is a fatal, hereditary disorder caused by a mutation in the gene encoding the protein huntingtin. Although mutant huntingtin is ubiquitously expressed throughout the body, HD research has mainly focused on the role of the basal ganglia. Dysfunction of these brain nuclei likely underlies motor disturbances in HD, including the conspicuous, uncontrollable, dance-like moveme

KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary

The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on the monitoring, management, and treatment of kidney transplant recipients is intended to assist the practitioner caring for adults and children after kidney transplantation. The guideline development process followed an evidence-based approach, and management recommendations are based on systematic reviews of

Update on the molecular pathogenesis and targeted approaches of mantle cell lymphoma: summary of the 12th annual conference of the European Mantle Cell Lymphoma Network

Mantle cell lymphoma (MCL) is a distinct subtype of malignant lymphoma which is characterized by the chromosomal translocation t(11;14)(q13;q32) resulting in constitutional overexpression of cyclin D1 and cell cycle dysregulation in almost all cases. Clinically, MCL shows an aggressive clinical course with a continuous relapse pattern and a median survival of only 3-5 years. However, recently a su

IGFBP1 and IGFBP3 polymorphisms predict circulating IGFBP-3 levels among women from high-risk breast cancer families.

The insulin-like growth factor (IGF) pathway has been implicated as risk modifier in premenopausal breast cancer. In this study, associations between single nucleotide polymorphisms (SNPs) and diplotypes in the IGFBP1 and IGFBP3 genes and circulating IGFBP-3 levels, BRCA family status and breast cancer among women from high-risk breast cancer families were investigated. Nine IGFBP1 and IGFBP3 SNPs

Co-selection for antibiotic tolerance in Cu-polluted soil is detected at higher Cu-concentrations than increased Cu-tolerance

Co-selection for antibiotic tolerance in Cu polluted soils was studied in a laboratory experiment. Pollution Induced Community Tolerance (PICT) of the bacterial community was estimated using leucine incorporation. PICT was found in Cu polluted soils to tetracycline (>= 8 mmol Cu kg(-1)), tylosin (>= 16 mmol Cu kg(-1)) and vancomycin (>= 16 mmol Cu kg(-1)). PICT to the antibiotics was found at high

Large eddy simulation of n-Dodecane spray combustion in a high pressure combustion vessel

Autoignition and stabilization of n-Dodecane spray combustion under diesel engine like conditions are investigated using large eddy simulation and detailed chemical kinetics. The Spray A cases of Engine Combustion Network (ECN) with ambient temperatures of 900 K and 1000 K are considered. Two-stage ignition behavior is predicted in the studied conditions. It is found that the first-stage ignition

Chronic non-bloody diarrhoea: a prospective study in Malmö, Sweden, with focus on microscopic colitis.

Chronic non-bloody diarrhoea affects up to 5% of the population. Microscopic colitis is one of the most common causes, encompassing the subtypes collagenous colitis and lymphocytic colitis. The diagnosis of microscopic colitis is made by histological examination of colonic mucosal biopsy specimens. The aim of this investigation was to determine whether laboratory parameters or questions about dise

Decision-making in critical situations during pregnancy and birth

The overall aim of this thesis was to describe the experiences of obstetricians and parents and the attitudes of midwives in relation to critical situations during pregnancy and birth. The data collection (Paper I and II) started in year 2000 with interviews with obstetricians (n=14) concerning the meaning of being in ethically difficult situations. During 2002 to 2004 interviews with parents (n=2

Supersensitive gastrin assay using antibodies raised against a cholecystokinin homolog

Peptide hormones may occur in particularly low amounts in samples from small animals. Hence, in a rat microdialysis study conventional immunoassays were not sufficiently sensitive to measure gastrin in the dialysis samples. We therefore exploited the observation that antibodies raised against the homologous hormone cholecystokinin (CCK) occasionally bind gastrin peptides with significantly higher

On the Decentralized H2 Optimal Control of Bilateral Teleoperation Systems with Time Delays

Decentralized control of bilateral teleoperation systems with time delays is considered within the H2 optimization framework. We demonstrate that the problem is quadratically invariant and can be split into two independent model matching optimizations with partial multiplicative delay. The recent loop shifting techniques for delayed systems control are used then to find a complete analytical solut

Accuracy of Equivalent Roughness Height Formulas in Practical Applications

This paper presents a discussion on the application and accuracy of roughness height formulas from a practical point of view. Such formulas have been proposed to describe the equivalent roughness height for plane bed conditions on the basis of the Shields parameter. The application of these relationships requires an iterative solution technique. However, as this paper demonstrates, the roughness e

Use of Inhaled Corticosteroids in Patients With COPD and the Risk of TB and Influenza A Systematic Review and Meta-analysis of Randomized Controlled Trials

Background: The use of inhaled corticosteroids (ICSs) is associated with an increased risk of pneumonia in patients with COPD. However the risks of other respiratory infections such as TB and influenza remain unclear. Methods: Through a comprehensive literature search of MEDLINE EMBASE CINAHL Cochrane Library and ClinicalTrials.gov from inception to July 2013 we identified randomized controlled tr