Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Objectives: There are several breast cancer (BC) risk factors—many related to body composition, hormonal status, and fertility patterns. However, it is not known if risk factors in healthy women are associated with specific mammographic features at the time of BC diagnosis. Our aim was to assess the potential association between pre-diagnostic body composition and mammographic features in the diag

Microplastics are pervasive throughout aquatic ecological communities. While their negative impacts on the life history traits of aquatic species are well studied, the effects on community dynamics remain elusive. Consequently, community-level assessments of microplastic effects on marine food webs are largely lacking, creating significant knowledge gaps regarding marine ecosystem structure and dy

Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re

The awareness of employee-driven innovation (EDI) and its strategic relevance to corporate development has recently increased. The implications of EDI are vigorously discussed in terms of inclusive approaches; particularly focussing on how managerial structures can enable employee participation. This paper focusses on game-based formats to enhance such participation and explores what participation

Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative

Background: The incidence of celiac disease (CD) has increased rapidly in the late 20th and early 21st centuries, but there are recent reports of rates levelling off in countries with a high prevalence. The aim of this study was to investigate current trends in CD in southern Sweden. Patients and methods: Children and adults diagnosed with CD by biopsy or serology in the region of Skåne, southern

Increasing demand for renewable energy and rapid tourism growth point to the need for a better overview of the factors affecting the compatibility of renewable energy infrastructure (REI) with tourism. This study aims to systematically review existing research on the interrelationships between REI and tourism, to identify their type and character and the factors affecting them, and to critically d

We show with Gaia XP spectroscopy that extremely metal-rich (EMR) stars in the Milky Way ([M/H]XP ≳ 0.5) are largely confined to a tight "knot"at the center of the Galaxy. This EMR knot is round in projection, has a fairly abrupt edge near RGC,proj ∼ 1.5 kpc, and is a dynamically hot system. This central knot also contains very metalrich (VMR; +0.2 . [M/H]XP . +0.4) stars. However, in contrast to

The Swedish Quality Registry for Pain rehabilitation (SQRP) is a well-established clinical registry for adult patients with complex chronic pain conditions. SQRP registers patient-reported outcome measures from a majority of specialist chronic pain units/departments in Sweden. Up to four International Classification of Diseases version 10 (ICD-10) diagnoses can be registered in SQRP. The aim of th

Hemslöjdspionjären Lilli Zickerman (1858–1949), som tog initiativ till bildandet av Föreningen för svensk hemslöjd, var under nära fyra decennier bosatt i Vittsjö. Det var därifrån som hon tillsammans med flera familjemedlemmar, som också flyttat dit, arbetade med en stor inventering av svensk folklig textilkonst. Inventeringsmaterialet, som bär namnet ”Föreningen för svensk hemslöjds samlingsverk

The accumulation of amyloid fibrils from the protein 𝛼-synuclein is a pathological hallmark of Parkinson´s disease. 𝛼-synuclein is a highly polar protein with a remarkable primary structure that can be divided into three regions: the slightly basic N-terminal region, a central hydrophobic region, and a highly acidic C-terminal tail. The C-terminal tail is of specific focus in this thesis. A chan

Almost 20 years ago, MSB's representatives published general advice and comments on fire protection at camping facilities (SRVFS2004:12). However, this is considered general advice and is not technically mandatory. This advice is linked to 2 kap. 2 § of the Act (2003:778) on protection against accidents, which in this case points out an obligation for owners and users of camping facilities to main

Background: Including people with severe/profound intellectual disabilities as research participants challenges researchers due to their diverse abilities to participate and express themselves. Ensuring the rigour of the research and the credibility of the findings presents a challenge.Methods: We use examples from our research to demonstrate that Classic Grounded Theory offers a systematic but fl

Diskussion om jazzgitarristen Django Reinhardt,

Timely light exposure is a vital aspect to achieve better sleep and well-being. As there are risks with a disturbed circadian rhythm and benefits with light settings that stimulate the rhythm, the circadian effective light, circadian stimulus (CS), for radiographers was examined. Aim: The aim of the study was to compare radiographers’ light environment on the workstations, at a university hospital

Design thinking is an innovative methodology that may be applied by small and medium enterprises which emphasizes a human-centered approach to problem-solving, facilitating the creation of novel solutions for complex and open-ended challenges like the development of new products. Despite its recognized importance in business and academia, many industrial SMEs struggle with applying design thinking