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Background: Interleukin 1 beta ( IL- I beta) is found in bronchoalveolar lavage fluids from asthmatic patients and plays an important role in normal immunoregulatory processes but also in pathophysiological inflammatory responses. The present study was designed to investigate if IL- I beta could be involved in the development of airway hyperresponsiveness and if transcriptional mechanisms, epithel

I examine the relationship between reproductive success and marker-based relatedness (MBR; inferred from variation at 21 microsatellite loci) of pair-mates in a semi-isolated population of great reed warblers (Acrocephalus arundinaceus) over a 12 year period. There was a negative relationship between egg-hatching success and MBR, but no association between MBR and three other components of fitness

PURPOSE: To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function. PATIENTS AND METHODS: Forty-eight patients presented with unilateral testicular germ cell cancer and CIS of the contralateral testis. The CIS-bearing testis was treated with daily irradiation doses of 2 Gy, 5 days a week, to a cumulative dose of 20

Cutting edge deteriorations are attributed to higher mechanical and thermal stresses working on it during metal cutting. However, the stress estimation is a difficult task, especially when on-line estimation is desired. This paper presents a new approach for cutting edge mechanical stress estimation and load simulation. The approach can be applied in the implementation of on-line stress estimation

The ionizable amino acid side chains of proteins are usually located at the surface. However, in some proteins an ionizable group is embedded in an apolar internal region. Such buried ionizable groups destabilize the protein and may trigger conformational changes in response to pH variations. Because of the prohibitive energetic cost of transferring a charged group from water to an apolar medium,

Different ways of approximating the exchange-repulsion energy with a classical potential function have been investigated by fitting various expressions to the exact exchange-repulsion energy for a large set of molecular dimers. The expressions involve either the orbital overlap or the electron-density overlap. For comparison, the parameter-free exchange-repulsion model of the effective fragment po

Two ways of mounting distinguishing attacks on two similar stream ciphers, SOBER-t16 and SOBER-t32, are proposed.. It results in distinguishing attacks faster than exhaustive key search on full SOBER-t16 and on SOBER-t32 without stuttering.

In both mice and humans alternate splicing results in isoforms of c-Kit characterized by the presence or the absence of a tetrapeptide sequence, GNNK, in the juxtamembrane region of the extracellular domain. Dramatic differences in the kinetics and magnitude of activation of the intrinsic tyrosine kinase activity of c-Kit between the GNNK and GNNK+ isoforms has previously been shown. Here we repor

Six species of Candelariella with polysporous asci are recognized from western North America. The species are: C. borealis sp. nov., C. efflorescens, C. lutella, C. placodizans, C. vitellina and C. xanthostigma. Candelariella vitellina is lectotypified. A key to the polysporous species in western North America is provided and their distribution in the study area is mapped.

Consider the Sobolev embedding operator from the space of functions in W-1,W-p(I) with average zero into L-p, where I is a finite interval and p > 1. This operator plays an important role in recent work. The operator norm and its approximation numbers in closed form are calculated. The closed form of the norm and approximation numbers of several similar Sobolev embedding operators on a finite inte

Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase. We have found that some plants and yeast also have an acyl-CoA-independent mechanism for TAG synthesis, which uses phospholipids as acyl donors and DAG as acceptor. This reaction is cataly

For 10 consecutive winters, measurements were carried out in Lake Vendyurskoe, Karelia, Russia. The aim of these measurements was to investigate some of the physical processes in this small shallow lake during its ice-covered period. Detailed measurements of ice thickness and condition, snow thickness, water temperature, salt content, and currents were developed into a database. Within this databa

The role of the Laude g-factor in atomic spectroscopy is explored through theoretical studies for Ne I and Ne II where some experimental values are available. Extended correlation studies in the Breit-Pauli approximation for spectrum calculations are analysed and compared with experiment and other theory. For Ne II, the multiconfiguration Dirac-Hartree-Fock method was also applied, but correlation

OBJECTIVES: To study whether intrauterine growth restriction (IUGR) is associated with decreased sensitivity to the main fetal growth factor, insulin, and the effect of glucocorticoid therapy on insulin sensitivity in preterm infants. STUDY DESIGN: Newborn infants with a birth weight (BW) of< 1500 g were classified as appropriate for gestational age ([AGA], BW within +/- 1 SD, n = 10), or small fo

In pre-industrial Sweden (and other parts of' northwestern Europe) retirement arrangements were used by peasants to keep their property intact and to transfer it to one of the children while the other children were compensated with, for example, movable property or plots of land. In this article we study the frequency and form of this strategy in pre-industrial rural Sweden. While the literature o

Simultaneous saccharification and fermentation (SSF) of wood has been modeled for the past 15-20 years, but the substrates used for model evaluation have so far not included pretreated softwood. In the present study, data from lab-scale batch SSF of SO2-impregnated, steam-pretreated spruce chips were used to evaluate a model found in the literature. The model, which was somewhat modified, consists

Aims/hypothesis Events during fetal life may in critical time windows programme tissue development leading to organ dysfunction with potentially harmful consequences in adulthood such as diabetes. In rats, the beta cell mass of progeny from dams fed with a low-protein (LP) diet during gestation is decreased at birth and metabolic perturbation lasts through adulthood even though a normal diet is gi