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In a recent study from the SCC group of Niels-Bjarne Woods and collaborators, they have investigated the metabolic changes accompanying the emergence of blood during embryonic development. They discovered a previously unknown metabolic switch during endothelial to hematopoietic transition (EHT), the process by which the first blood cells are formed. This switch showed to be crucial in the determin
Ludwig Schmiderer has studied how to overcome delivery challenges in stem cell biology with nanotechnology. In this interview, he tells us about his research and generative art. What have you been working with during your PhD studies? At the beginning of my PhD, I was trying to reengineer the CRISPR/Cas9 system to make it work in mitochondria instead of nucleus. The project started off quite well
https://www.stemcellcenter.lu.se/article/phd-defence-interview-ludwig-schmiderer - 2025-12-19
Stem cell transplantation is a cornerstone in the treatment of blood malignancies. In order to succeed, stem cells need to be harvested from a donor. This requires that hematopoietic stem and progenitor cells (HSPC) are mobilized from the donor’s bone marrow into the blood. In a new study, the Nilsson lab discovered DNA sequence variants that regulate HSPC levels in human blood, exposing potential
The Pereira research group has previously shown that it is possible to reprogram human skin cells into dendritic cells that strengthen the immune system. However, the efficiency of these reprogrammed cells has been shown to be very low. New studies now indicate that there are ways to increase the efficiency of these reprogrammed cells by over 75%. These findings provide mechanistic insights into h
https://www.stemcellcenter.lu.se/article/new-findings-indicate-ways-increase-efficiency-reprogrammed-immune-cells - 2025-12-19
Anna Fossum, Project Manager at the StemTherapy FACS Core Facility research infrastructure, has been sorting cells with a variety of types of FACS machines for the past 23 years. But she hasn’t gotten tired yet of the job – quite the opposite. And now she has a new and more powerful member of the “FACS family” to look after. “I really love my job! It’s stimulating to meet so many people and hear a
https://www.stemcellcenter.lu.se/article/new-addition-lund-stem-cell-center-facs-facility - 2025-12-19
Researchers from Lund University, building on previous studies, have been working to understand why stem cells are transforming into cancer. Previously they revealed that small RNA molecules, long considered “junk” or degradation byproducts of RNA-sequencing, are emerging as key regulators of important cellular processes, like protein synthesis. Their latest discovery is published in Nature Cell B
https://www.stemcellcenter.lu.se/article/what-makes-stem-cells-transform-cancer-answer-may-lie-our-rna - 2025-12-19
Svetlana Soboleva is set to defend her Ph.D. thesis on 13 April, 2022. For the past few years her world has revolved around red blood cells, as she has worked to establish methods that allow for the generation of enucleated cells, using immortalized erythroid cell lines, to develop erythrocytes. In short, she’s been working to find ways to produce red blood cells in a lab. In this interview she te
https://www.stemcellcenter.lu.se/article/blood-lab-phd-defence-interview-svetlana-soboleva - 2025-12-19
This year Lund Stem Cell Center and MultiPark, two strategic research areas based at Lund University, are happy to launch a new joint technical platform in an effort to ensure easy access to high quality core electrophysiology techniques and expert knowledge for investigating cells and tissues that exhibit electrical properties. In 2009, the Swedish government decided to invest in strategic resear
The Marie Skłodowska-Curie Actions (MSCA) fund excellent research and innovation. This March, the MSCA awarded €242m to the 2021 Postdoctoral Fellowships applicants – among them, a researcher from Lund University, Camila Vazquez Echegaray, aiming to uncover regulators of plasticity in cell fate decision. The MSCA are the EU’s flagship funding programme for doctoral education and postdoctoral train
https://www.stemcellcenter.lu.se/article/msca-postdoctoral-fellowship-awarded-camila-vazquez-echegaray - 2025-12-19
Cancerfonden continues to fund the foremost cancer research in Sweden – investing in cancer research that makes a difference. Last month, Cancerfonden distributed SEK 37 million to eight researchers at Lund University whose work will contribute to defeating cancer. Included in this group of talented researchers, is postdoctoral researcher, Dr. Sowndarya Muthukumar, from the Lund Stem Cell Center.
https://www.stemcellcenter.lu.se/article/cancerfonden-awards-sowndarya-muthukumar-postdoctoral-fellowship - 2025-12-19
Cancer is a genetic disease, caused by a change in the genes which make up our DNA. Normally one change or mutation is not enough to trigger the development of cancer, instead cancer is typically comprised of a combination of genetic mutations. Researchers at Lund University have now revealed a novel somatic gene mutation is involved in the formation and progression of acute myeloid leukemia. The
Researchers from Lund University, led by Dr. Laurent Roybon, are working to further define underlying mechanisms involved in neurodegenerative diseases, such as Parkinson’s Disease and Multiple System Atrophy. Their latest discovery, published in PNAS, could be used to devise novel therapeutic approaches to treat neurodegenerative diseases such as these, as well as other synucleiopathies in the fu
Lund Stem Cell Center provides researchers with access to core facilities equipped with the latest technologies, specialist expertise and instruction on the use of the different equipment. Over time these facilities have evolved to form the well-developed technological infrastructure which exists today. Earlier this year, the Center, in partnership with MultiPark, took the next step in the evoluti
We are happy to announce that Sandeep Gopal, a researcher within the Department of Experimental Medical Sciences at Lund University, has now joined Lund Stem Cell Center. In his new role as Principal Investigator and leader of the research group on Extracellular Signaling and Cell Fate, he aims to better understand how extracellular molecules control cell fate and cell behavior. Previously based i
https://www.stemcellcenter.lu.se/article/lund-stem-cell-center-welcomes-new-member-sandeep-gopal - 2025-12-19
Researchers at Lund University have recently sought to shed more light on how normal hematopoietic stem cells (HSCs) produce a vast variety of blood cells. Their latest findings, now out in Cell Reports this week, confirm the existence of a transition state as HSCs develop into functional blood cells and provide insights into how certain properties of HSCs are lost as these cells decide their fate
https://www.stemcellcenter.lu.se/article/shedding-new-light-intermediate-cell-states-stem-cells-decide-their-fate - 2025-12-19
By using cells isolated from cancer patients and mixing them with a new technology called “OssiGel”, it is possible to engineer human mini-bones. These miniaturized organs consist of mature bone and marrow tissue and can be used as model to study the disease mechanisms behind cancers that arise in bone marrow or spread to the bones, and offer the personalized testing of new drugs. Paul Bourgine is
https://www.stemcellcenter.lu.se/article/miniature-bones-research-model-cancer - 2025-12-19
A study conducted by researchers at Lund University has found that protein oxidation forms an additional layer of regulation during the development of fetal blood stem cells and may play a role in the development of leukemia. The results are now available in the journal, Redox Biology. The human body is made up of trillions of cells and within each are proteins - large, complex molecules that play
https://www.stemcellcenter.lu.se/article/protein-oxidation-added-layer-regulation-during-blood-stem-cell-development - 2025-12-19
Life is like a marathon. According to Dr. Anders Björklund, a pioneer and expert in cell replacement strategies for patients with Parkinson’s Disease, so is life in academia. Along his scientific run he has passed several milestones, the most recent being a jubilee honorary doctorate awarded by Lund University in celebration of his decades of contributions to neuroscience. We sat down with Anders
Researchers from Lund University interested in understanding how aging affects the brain have made a new discovery that will help make it easier to study age-related brain diseases and potential treatments in the future. The key to this? human skin cells. The human brain is often likened to the night sky. Look up and one will see billions upon billions of stars. Our brains are similar in that with
https://www.stemcellcenter.lu.se/article/how-our-skin-cells-might-be-key-better-understanding-human-brain - 2025-12-19
Årets Nobelpris i fysik gick i klimatmodelleringens tecken. Birgitta Svenningsson, lektor i fysik och biträdande koordinator vid MERGE (Modelling the Regional and Global Earth system), gläds åt Syokuro Manabe, Klaus Hasselmann och Giorgio Parisi som delar årets pris. Det blev storslam för klimatmodelleringen i år, är du förvånad? – Det är mycket positivt att den uppmärksammas på detta sätt. Dagens
https://www.fysik.lu.se/artikel/lundaforskare-hyllar-arets-fysikpristagare - 2025-12-19
