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Genomic characteristics of soft tissue sarcomas.

Studies on the molecular mechanisms behind soft tissue sarcoma development have disclosed that these malignancies are as genetically heterogeneous as they are clinically and morphologically diverse. Much of the genetic information on soft tissue sarcomas is still limited to the genomic level, as detected by chromosome banding analysis or comparative genomic hybridization. Based on the results of s

New domino logic precharged by clock and data

A clock-and-data precharged dynamic (CDPD) circuit technique in CMOS is presented. It gives a fast one-clock-cycle decision to multilevel logic and has small clock loads, low peak current, small area and low power-delay product. The technique is highly flexible in logic design. For the given example, a 324bit binary-lookahead-carry chain, the speed improvement can be as high as 40–50% compared to

Patterns of multiple myeloma during the past 5 decades: stable incidence rates for all age groups in the population but rapidly changing age distribution in the clinic.

OBJECTIVE: To define age-adjusted incidence trends in multiple myeloma (MM) in a well-characterized population during a long period, given that some, but not all, studies have reported increasing MM incidence over time and that clinical experience from some centers suggests an increased incidence mainly in younger age groups. PATIENTS AND METHODS: We identified all patients (N=773) with MM diagnos

Towards a theory of lexical meaning as ontologies and construals

The purpose of this paper is to propose a framework of lexical meaning, broadly along the lines of Cognitive Semantics (Langacker 1987a). The paper focuses on interpretations of adjective-noun (ADJ N ) combinations in English. Within the proposed model, all aspects of meaning are to be explained in terms of properties of ontologies in conceptual space, i.e. properties of content ontologies and sch

Chimney grafts preserve visceral flow and allow safe stenting of juxtarenal aortic occlusion.

OBJECTIVE: Chimney grafts have proven useful for urgent endovascular repair of juxtarenal aortic aneurysms. Stenting of juxtarenal aortic occlusive disease is not routinely advocated due to the risk of visceral artery obstruction. We report on the potential applicability of chimney grafts in 10 patients with juxtarenal aortic stenosis or occlusion. To our best knowledge, chimney grafts have not be

GAFCHROMIC FILM AS A FAST VISUAL INDICATOR OF RADIATION EXPOSURE OF FIRST RESPONDERS.

Three types of Gafchromic films have been studied to investigate their potential for use as a visually readable dosemeter for persons acting as first responders in connection with radiological or nuclear emergencies. The two most sensitive film types show a pronounced variation in sensitivity by photon energy and are therefore not suitable for use in cases of unknown exposures. The third film type

Sports camp with six months of support from a local sports club as a treatment of childhood obesity.

AIMS: Although childhood obesity is becoming increasingly prevalent, treatment options are limited and the continued development of effective treatment strategies is necessary. It is equally important to explore involvement of other resources in society, such as sports associations. This study was designed to investigate the possibility of reducing the degree of obesity in obese children by focusi

Precautions taken by mothers to prevent burn and scald injuries to young children at home: An intervention study.

AIM: The aim of this study was to investigate to what extent individual-based extended information given to mothers from city parts of low education can improve precautions taken by them to prevent burn and scald injuries involving young children in the home and further to compare the results with a group of mothers who had not received extended information. METHODS: This intervention study, with

Advancing Upconversion Emissions for Biomedical Imaging

During the past decade, upconverting nanoparticles (UCNPs) doped with rare earth ions have become an important class of fluorescence contrast agents for molecular imaging, due to their unique properties. Their property of anti-Stokes luminescence, with both the excitation and emission wavelengths close to the optimal for biomedical imaging, has been extensively explored in various biomedical appli

Plasma Copeptin, A Unifying Factor behind the Metabolic Syndrome.

Context: Arginine vasopressin (AVP) is known to affect liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release. We previously showed that high copeptin, the stable C-terminal fragment of AVP prohormone, is independently associated with hyperinsulinemia and future development of diabetes mellitus. Objective: The objective of the study was to examine whether plasma copeptin