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Tumor antigens can emerge through multiple mechanisms, including translation of noncoding genomic regions. This noncanonical category of tumor antigens has recently gained attention; however, our understanding of how they recur within and between cancer types is still in its infancy. Therefore, we developed a proteogenomic pipeline based on deep learning de novo mass spectrometry (MS) to enable th

Background & aims: Tissue transglutaminase autoantibodies (tTGA) are used as diagnostic markers of celiac disease. Different methods have been developed for the detection of tTGA of which enzyme-linked immunosorbent assays (ELISA), radiobinding assays (RBA) and electrochemiluminescence (ECL) assays are the most commonly used. Here we aimed to evaluate a novel antibody detection by agglutinatio

The codes HiggsBounds and HiggsSignals compare model predictions of BSM models with extended scalar sectors to searches for additional scalars and to measurements of the detected Higgs boson at 125GeV. We present a unification and extension of the functionalities provided by both codes into the new HiggsTools framework. The codes have been re-written in modern C++ with native Python and Mathematic

Background: Complex level-of-care decisions involve uncertainty in which decisions are beneficial for older patients. Knowledge of physicians’ decision-making during acute situations in older patients’ homes is limited. Therefore, this study aimed to describe physicians’ experiences and actions in making complex level-of-care decisions during the assessment of older patients in acute situations wi

Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine to overcome tissue hormone resistance does not elevate their heart rate. Cardiac telemetry in male, TRα1 mutant, mice indicates that such persis

In this study, we apply a combination of methods for understanding how business models need to change to meet changing business conditions in the future (time horizon 2050). The process of applying the value proposition canvas and the business model canvas for understanding the future business models to the case of district heating has been documented. The energy transition necessitates a combinat

Background: To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed. These are reported in relation to levodopa as the benchmark drug in PD pharmacotherapy as ‘levodopa equivalent dose’ (LED). Currently, the LED conversion formulae proposed in 2010 by Tomlinson et al. based on a systematic review are predomi

Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress that worsens quality of life; however, long-term mental health outcomes are unclear. Objective: To determine the long-term risks of major depression and death by suicide in a large population-based cohort. Design, setting, and participants: This was a national cohort study of 180 189 men diagnosed with PC during 1998–2

In this chapter, it is argued that Mary Wollstonecraft’s (1759–1797) writings on morality and politics are usefully analyzed as comprehensive critique of hierarchy and inequality, as detrimental to freedom and virtue. Focus is placed on Wollstonecraft’s approach to doing philosophy, or her method. She regarded inequalities as moral deviations from proper standards of rightness but also as continge

The highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure, induced by the necessarily high energy of short-wavelength radiation. Imaging the inelastically scattered X-rays at a photon energy of 60 keV (0.02 nm wavelength) offers greater signal per energy transferred to the sample than coherent-scattering techniques such as phase

The performance of timber in exposed environments is affected by several biotic and abiotic factors. For timber cladding and decking, two important aspects include reduced structural performance due to fungal decay and aesthetical changes resulting from superficial effects such as photodegradation and moulds. Predicting the long-term performance of timber is important because it enables rational m

I et tidligere projekt støttet af Byggforskningsrådet undersøgtes virkningen af atarmere bolte- og sømforbindelser med glasfiber. Forsøg viste, at armeringenvar meget effektiv.I det projekt, som beskrives i denne rapport, er undersøgt armering af bolteforbindelser belastet vinkelret på fibrene i relativt store trætykkelser (90 mm limtræ). Der blev som armering anvendt glasfiber og også 6 mm birkek

In recent years, conspiracy theories have been increasingly defined as a new social enemy, a threat to democracy. But scholars of conspiracy theories also point out that we have very little research that examines a direct link between conspiracy theories and political practice. We still know very little about the ways in which conspiratorial beliefs influence different forms of civic engagement an

This lead article in a JCMS symposium marking 20 years of normative power provides a prospective intervention into thinking through the rest of the century by taking the language of Arrival, the 2016 speculative fiction film based on Ted Chiang's 1998 short ‘Story of Your Life’ and applying it to normative power by double-decolonising the anthropocentrism of capitalist culture and Eurocentrism in

Mutation-bearing peptide ligands from mutated nucleophosmin-1 (NPM1) protein have been empirically found to be presented by HLA class I in acute myeloid leukemia (AML). We hypothesized that HLA genotype may impact allogeneic hematopoietic stem cell transplantation (allo-HCT) outcomes in NPM1-mutated AML owing to differences in antigen presentation. We evaluated the effect of the variable of predic

The language that individuals use for expressing themselves contains rich psychological information. Recent significant advances in Natural Language Processing (NLP) and Deep Learning (DL), namely transformers, have resulted in large performance gains in tasks related to understanding natural language. However, these state-of-the-art methods have not yet been made easily accessible for psychology

Introduction The coefficient of fat absorption (CFA) quantifies fat that remains in stool after digestion and is not a direct measure of lipolysis. CFA has been used to assess treatment of pancreatic insufficiency but does not correlate with pancreatic enzyme replacement therapy dose. We explored use of an omega-3 substrate absorption challenge test as a sensitive test of lipolysis and absorption.

Purpose: To analyse trends of ISBCS reported to the Swedish National Cataract Register (NCR) over a 10-year period. Methods: Since 2010 the NCR contains social security number of all individuals in the list of parameters reported to NCR after each cataract procedure. Bilateral surgeries were mapped out using social security numbers. When dates of both-eye surgeries are identical for an individual

In soil, arbuscular mycorrhizal fungi (AMF) meet the roots of both host and presumed nonhost plants, but the interactional mechanisms of AMF with and functional relevance for nonhost plants is little known. Here we show AMF can colonize an individually grown nonhost plant, Arabidopsis thaliana, and suppress the growth of Arabidopsis and two nonhost Brassica crops. This inhibitory effect increased