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The enzymatic synthesis of dipeptide units of the d-d-configuration in aqueous media, catalysed by muramoyl-pentapeptide carboxypeptidase (E.C.3.4.17.8), is described. Ac-l-Lys(Ac)-d-Ala-d-Lac-OH and Ac-d-Ala-OMe were used as acyl-components. Neutral, basic, and hydrophobic amino acids acting as nucleophiles were incorporated. The enzyme is stereospecific in that only the d-enantiomers of amino ac
According to the polygyny threshold model, females are compensated for the cost of sharing a territory with other females by breeding in territories of higher quality than those of monogamously mated females. In the polygynous Great Reed Warbler (Acrocephalus arundinaceus), the variation in territory quality may be associated with nest site characteristics or food supply. In this study, we examine
The number of elderly people is gradually increasing, and with it the number of persons receiving some kind of care in their everyday lives. However, researchers and the mass media recurrently report great difficulties for many caregivers in their work situations. This article considers process-oriented supervision as a pedagogic method for training and support of nurse aids and managers in Swedis
Differential dijet cross sections are measured in photoproduction in the region of photon virtualities Q(2) < 1 GeV2 with the H1 detector at the HERA ep collider using an integrated luminosity of 66.6 pb(-1). Jets are defined with the inclusive k perpendicular to algorithm and a minimum transverse momentum of the leading jet of 25 GeV is required. Dijet cross sections are measured indirect and res
The fluoroquinolone sensitivity of Pseudomonas aeruginosa and Klebsiella pneumoniae was studied by determinations of Minimum Inhibitory Concentrations (MICs) of norfloxacin and ciprofloxacin in consecutive clinical isolates. In P. aeruginosa, resistance or reduced susceptibility (MIC > or = 8 mg/l for norfloxacin and > or = 2 mg/l for ciprofloxacin) was found in 17% (9/54) of the isolates. Reduced
One-nucleon removal reactions at relativistic energies have been used as a spectroscopic tool for obtaining information about the ground state of neutron-rich oxygen isotopes. Using the FRS at GSI, the longitudinal momentum distributions of the emerging fragments after breakup were measured along with the one-nucleon removal cross-sections. The relative contributions of the remaining fragments in
The Interpersonal Addition Theorem, due to John Broome, states that, given certain seemingly innocuous assumptions, the overall utility of an uncertain prospect can be represented as the sum of its individual (expected) utilities. Given ‘Bernoulli’s hypothesis’, according to which individual utility coincides with individual welfare, this results appears to be incompatible with the Priority View.
Protein S deficiency is an autosomal dominant disorder that results from mutations in the PROS I gene. Conventional mutation detection techniques fail to detect a pathogenic PROSI mutation in approximately 50% of cases. The present study investigates whether large deletions of PROS I are found in families where mutations in the PROS I gene have not been found despite sequencing. For this purpose,
The diversion of pancreatic juice and bile stimulates pancreatic exocrine secretion but the mechanism behind this process is still not clear. The present study investigates the influence of long lasting (10 h) bile diversion or pancreatic juice and bile diversion on the pancreatic secretion in conscious pigs. The experiments were performed on 4 weaned piglets, which had a catheter inserted to the
I-131 radionuclide therapy studies have not shown a strong relationship between tumor absorbed dose and response, possibly due to inaccuracies in activity quantification and dose estimation. The goal of this work was to establish the accuracy of I-131 activity quantification and absorbed dose estimation when patient-specific, 3-dimensional (3D) methods are used for SPECT reconstruction and for abs
In this paper the predictive capability of the smoke transport model CFAST 2.0 is evaluated for five different scenario configurations. The evaluation is made by statistical analysis according to a methodology presented in an earlier paper. Model predictions and experimental data, previously published, are compared and quantitative measures of the predictive capability are thus derived. With the q
Advanced glyeation end products (AGEs) are thought to play a major pathogenic role in diabetic retinopathy. The most important AGE is unknown, but as increased serum methylglyoxal-derived hydroimidazolone has been demonstrated in patients with type 2 diabetes mellitus, the aim of the present study was to elucidate possible associations between serum levels of hydroimidazolone and retinopathy in pa
The Rhodobacter capsulatus BchI protein is one of three subunits of Mg chelatase, the enzyme which catalyzes the first committed step of chlorophyll and bacteriochlorophyll biosynthesis. The BchI protein was produced with an inducible T7 RNA polymerase expression system in Escherichia coli. The protein was purified from the soluble cell-extract fraction and crystallized from polyethylene glycol so
Impaired appetite and weight changes are commonly seen in patients with depression, but the pathophysiology behind this imbalance between energy intake and energy expenditure remains largely unknown. The aim of this paper is to review the literature regarding a possible role for cytokines in the regulation of appetite and body weight, with special emphasis on depression. There now exists a substan
This is a study of the second century AD literary work 'Periegesis Hellados', i.e. description of, or guide to, Greece, written by the otherwise unknown author Pausanias. This is a purely textual study with the whole of the Periegesis as its object. It falls into two parts. In part one we study the frame narrative. The current views on the 'theoremata' and 'logoi' in the Periegesis is reconsidere
Case study is an important research methodology for software engineering. We have identified the need for checklists supporting researchers and reviewers in conducting and reviewing case studies. We derived checklists for researchers and reviewers respectively, using systematic qualitative procedures. Based on nine sources on case studies, checklists are derived and validated, and hereby presented
