Aims: To show that a thrice daily meal-time biphasic insulin aspart (BIAsp) treatment regimen is as efficacious as a 4 times daily basal-bolus regimen with human isophane insulin (NPH) and insulin aspart (IAsp). Methods: A multinational, randomised, open-label parallel-group trial in 394 patients with type 2 diabetes on a once or twice daily insulin regimen. Patients were randomised 1:1 to BIAsp o

In ERP studies of adults, semantic incongruities elicit a, late negative response called the N400. Recently it was demonstrated that the amplitude of the N400 is sensitive to the organization of semantic categories in memory. The present study sought to investigate whether a similar incongruity response can be identified in children in their second year of life and whether this response is sensiti

The protein kinase C (PKC) isoforms are maintained in an inactive and closed conformation by intramolecular interactions. Upon activation these are disrupted by activators, binding proteins and cellular membrane. We have seen that autophosphorylation of two sites in the C-terminal V5 domain is crucial to keep PKC alpha insensitive to the activator diacylglycerol, which presumably is caused by a ma

The physiological impacts and fitness costs of parasitism by an introduced ectoparasitic fly, Philornis downsi (Muscidae), were studied in nestlings of Darwin's Small Ground Finch, Geospiza fuliginosa (Geospizinae), on the Galápagos Archipelago. Whole blood haemoglobin (Hb) concentration was used to measure host response to ectoparasitism due to its high repeatability and validity, as well as for

Stribeck's publications Wugellager fur beliebige Belastungen' and 'Die wesentlichen Eigenschaften der Gleit- und Rollenlager' were remarkable for their time. Many of the findings were revolutionary and are still considered quite modem. The method used by Stribeck to calculate load distribution between the balls within a ball bearing is still used today, otherwise, a full finite element analysis wo

In order to meet the expected enormous demand for mass spectrometry (MS)through-, put as a result of the current efforts to completely map the human proteome, this paper presents a new concept for low-cost high-throughput protein identification by matrix assisted laser desorption/ionization-time of flight-(MALDI-TOF)-MS peptide mapping using disposable polymeric high-density nanovial MALDI target

Toll-like receptors (TLRs) recognize specific pathogen-associated molecular patterns (PAMPs), which subsequently trigger innate immunity. Recent data also suggest a role for TLRs in the direct activation of adaptive immune cells. In the present study, the expression and function of TLR1-TLR10 were characterized in purified human tonsillar B cells, focusing on differences among CD19(+) CD38(-) CD27

Background— The extent to which differences in cardiovascular risk between smokers with similar daily tobacco consumption may be related to plasma levels of inflammation-sensitive proteins (ISP) and whether these proteins are associated with levels of carboxyhemoglobin (COHb%) have not been clarified. Methods and Results— In a population-based cohort of 1489 never smokers, 1685 former smokers, an

A rapid and sensitive liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the qualitative and quantitative assay of cyproheptadine (CP) in pharmaceutical samples. Diphenylpyraline hydrochloride (DPP) was used as an internal standard (IS). Two multiple reaction-monitoring (MRM) transitions for each analyte were observed: 288.1/96.1 and 288.1/191.2 for

Migration of 65 Charnley stems implanted with modern cementing techniques was studied by roentgen stereophotogrammetry. There were 25 patients with rheumatoid arthritis (RA) and 40 with osteoarthritis (OA) followed up for two years. In 43 cases a bone sample for histomorphometric analysis was obtained from the femur during the operation. In 22 cases the mean subsidence of the prosthetic head was 0

Men with prostate cancer initiating androgen-deprivation therapy (ADT) may have multiple factors that threaten their skeletal health, including increased fracture risk from bone loss during ADT and the propensity to develop bone metastases, which may lead to skeletal-related events (SREs). Bisphosphonates have utility in oncology for patients with bone metastases to prevent bone loss during hormon

This special issue presents the results of a European research project on the creative class in European city regions. In this introduction, the need for contextualizing the approach is underlined, taking into account the differences between the United States, where Richard Florida's ideas were developed, and Europe. In modifying the approach to suit European conditions, varieties of capitalism an

BACKGROUND: Approximately 570 patients are diagnosed with multiple myeloma (MM) in Sweden each year. Few studies have estimated the cost of treatment for these patients. OBJECTIVE: The purpose of this study was to retrospectively investigate the direct hospital resource utilization and costs associated with the treatment of patients with MM in southwest Sweden. METHODS: Patients aged > or =18 year

This paper presents a method of optimal coordination of load shedding, capacitor switching and tap changer operation using a dynamic system model in order to preserve or retain long-term voltage stability. The method is based on model predictive control and tree search. A model of the controlled system, including the network and load dynamics, is used to predict the future system behaviour based o

Background Low competence levels among nursing staff have been associated with lower quality of elderly care. However, interventions aimed at improving nursing staff competence have not always been evaluated for their possible impact on the quality of elderly care. An educational intervention in the form of a workplace “toolbox” was shown to have positive effects on nursing staff competence and wo

A technique to determine which nutrients limit bacterial growth in soil was developed. The method was based on measuring the thymidine incorporation rate of bacteria after the addition of C, N, and P in different combinations to soil samples. First, the thymidine incorporation method was tested in two different soils: an agricultural soil and a forest humus soil. Carbon (as glucose) was found to b

Solution properties of ethyl(hydroxyethyl)cellulose (EHEC) and a hydrophobically modified analogue (HM-EHEC) in water in the presence of various amounts of sodium dodecyl sulfate (SDS) have been investigated by cloud point (CP) measurements, titration microcalorimetry, and static light scattering. The CP experiments revealed that the hydrophobically modified polymer is less soluble than the unmodi