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Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction

Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeostasis, i.e. biosynthesis, catabolism and transport across the cell membrane. In the present paper, we concentrate on results achieved using the polyami

Doktorandbarometern 2007

I Doktorandbarometern 2007 har över 700 doktorander vid Lunds universitet bidragit med sina erfarenheter av forskarutbildningen. En väsentlig del av dessa erfarenheter var gemensamma, trots att de representerade olika vetenskapsområden. Ett annat intressant resultat visade på betydelsen av doktoranders delaktighet och medarbetarskap i forskarutbildningsmiljön. De som huvudsakligen arbetade inom ra

Ischemic Stroke and Secondary Prevention in Clinical Practice A Cohort Study of 14 529 Patients in the Swedish Stroke Register

Background and Purpose-Secondary prevention is recommended after stroke, but adherence to guidelines is unknown. We studied the prescription of antiplatelet drugs, angiotensin-converting enzyme inhibitors, statins, and anticoagulant drugs and their relation to risk of death. Methods-Patients with first-ever ischemic stroke in 2005 were registered in the Swedish Stroke Register. Odds ratios, hazard

Cardiac rhabdomyoma mimicking haemodynamics of hypoplastic left heart syndrome

Cardiac rhabdonnyomas are rare and often regress spontaneously. However, the management of rhabdomyoma with severe inflow and outflow obstructions is a challenge. An infant with a massive left ventricular rhabdomyoma mimicking the haemodynamics of hypoplastic left heart syndrome is reported. Surgery could not be contemplated because the mitral valve leaflets and chordae were imbedded in the tumour

En proto-feminist

Översatt utdrag ur introduktionskapitlet till boken Mary Wollstonecraft and Feminist Republicanism.

Upper gastrointestinal bleeding: incidence, etiology and outcomes in a population-based setting

Objective. The authors aimed to investigate the incidence and outcomes of acute upper gastrointestinal bleeding (AUGIB) and to examine the role of drugs potentially associated with AUGIB. Methods. The study was prospective, population-based and consisted of all patients who underwent upper gastrointestinal endoscopy (UGE), during the year of 2010 at the National University Hospital of Iceland. Dru

IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis

Studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, have shown that B cells markedly influence the course of the disease, although whether their effects are protective or pathological is a matter of debate. EndoS hydrolysis of the IgG glycan has profound effects on IgG effector functions, such as complement activation and Fc receptor binding, suggesting

Categorisation of Complications and Validation of the Clavien Score for Percutaneous Nephrolithotomy

Background: Although widely used, the validity and reliability of the Clavien classification of postoperative complications have not been tested in urologic procedures, such as percutaneous nephrolithotomy (PCNL). Objective: To validate the Clavien score and categorise complications of PCNL. Design, setting, and participants: Data for 528 patients with complications after PCNL were used to create

Two models to simulate rate-dependent domain switching effects - application to ferroelastic polycrystalline ceramics

The aim of this paper is to study rate-dependent switching in ferroelastic materials. More specifically, a micro-mechanically motivated model is embedded into an iterative three-dimensional and electromechanically coupled finite element framework. An established energy-based criterion serves for the initiation of domain switching processes as based on reduction in (local) Gibbs free energy. Subseq

Transverse-energy distributions at midrapidity in p plus p, d plus Au, and Au plus Au collisions at root s(NN)=62.4-200 GeV and implications for particle-production models

Measurements of the midrapidity transverse-energy distribution, dE(T)/d eta, are presented for p + p, d+Au, and Au+Au collisions atv root s(NN) = 200 GeV and additionally for Au+Au collisions atv root s(NN) = 62.4 and 130 GeV. The dE(T)/d eta distributions are first compared with the number of nucleon participants N-part, number of binary collisions N-coll, and number of constituent-quark particip

Academics' entrepreneurship propensities and gender differences

Using survey data from a large public research organization, this study examines entrepreneurship propensities of academic researchers, focusing on gender differences. Although sample means of female and male propensities toward entrepreneurship are fairly similar, regression estimates show significant gender differences in the association of several factors with propensities to start businesses.

The Gaia-ESO Survey: radial metallicity gradients and age-metallicity relation of stars in the Milky Way disk

We study the relationship between age, metallicity, and alpha-enhancement of FGK stars in the Galactic disk. The results are based upon the analysis of high-resolution UVES spectra from the Gaia-ESO large stellar survey. We explore the limitations of the observed dataset, i.e. the accuracy of stellar parameters and the selection effects that are caused by the photometric target preselection. We fi

Towards an instrument targeting mobility-related participation: Nordic cross-national reliability

Objective: To investigate test-retest reliability and internal consistency of a new instrument for evaluation of mobility device interventions. Material and methods: The instrument comprised 4 scales and one summed index. Two test-retest interviews involved 147 mobility device users (mean age 60 years) with a broad range of functional limitations, living at home. Results: For 2 scales and the summ

A comparison between different methods to determine moisture transport properties of cementitious materials

A number of methods for measuring moisture transport properties of cementitious materials were compared in a series of experiments. Two OPC mortars with two water-binder-ratios were wet cured for six months and used to produce specimens as discs with different thicknesses and diameters. The cup methods were easy to use, reliable and fairly rapid but need a stable, surrounding, CO2-free climate, ho

Fast-framing ballistic imaging of velocity in an aerated spray

We describe further development of ballistic imaging adapted for the liquid core of an atomizing spray. To fully understand spray breakup dynamics, one must measure the velocity and acceleration vectors that describe the forces active in primary breakup. This information is inaccessible to most optical diagnostics, as the signal is occluded by strong scattering in the medium. Ballistic imaging mit

Spin resonance without spin splitting

We predict that a single-level quantum dot without discernible splitting of its spin states develops a spin-precession resonance in charge transport when embedded into a spin valve. The resonance occurs in the generic situation of Coulomb blockaded transport with ferromagnetic leads whose polarizations deviate from perfect antiparallel alignment. The resonance appears when electrically tuning the

Search for a heavy gauge boson decaying to a charged lepton and a neutrino in 1 fb(-1) of pp collisions at root s=7 TeV using the ATLAS detector ATLAS Collaboration

The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W '), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 1.04 fb(-1). No excess above Standard Model expectations is observed. A W ' with S