There has been a long-standing interest in targeting the type 1 insulin-like growth factor receptor (IGF-1R) signaling system in breast cancer due to its key role in neoplastic proliferation and survival. However, no IGF-1R targeting agent has shown substantial clinical benefit in controlled phase 3 trials, and no biomarker has been shown to have clinical utility in the prediction of benefit from

Opus 106b. Composition: Alexander von Zemlinsky. Lyrics by Ferdinand Gregorovius, Constance Bache. A version of this work already exists for soprano and chamber orchestra, but I have adapted it for soprano and string quartet.

Introduction: Little is known of the processes that trigger neutrophil activation in the joint of patients with oligoarticular juvenile idiopathic arthritis (oJIA), and if synovial fibroblasts (S-Fib) play an important role in the activation. Therefore, we aimed to investigate whether S-Fib derived from oJIA patients drive neutrophil activation. Methods: Synovial fluid (SF) was collected from pati

Charge transfer between molecules lies at the heart of many chemical processes. Here, we focus on the ultrafast electron dynamics associated with the formation of charge-transfer-to-solvent (CTTS) states following X-ray absorption in aqueous solutions of Na+, Mg2+, and Al3+ ions. To explore the formation of such states in the aqueous phase, liquid-jet photoemission spectroscopy is employed. Using

Vegetable by-products, produced in large quantities worldwide, contain significant amounts of bioactive compounds and fiber, which have been shown to offer health benefits, such as regulating blood lipid levels. Dyslipidemia, a primary target in the clinical metabolic control of susceptible populations, is strongly influenced by diet. Hence, this systematic review aims to present the main findings

The emergence of pandemics like Covid-19 has raised important issues regarding the safe utilisation of spaces due to the potential for virus transmission in both enclosed and open built environments. This chapter explores the challenges posed by pandemics in terms of safe space utilisation, considering the potential virus transmission risks. It presents a risk analysis methodology that makes use o

While there is substantial evidence on excess mortality in the first two years of the COVID-19 pandemic, no study has conducted a cause-specific analysis of excess mortality for the whole period 2020–2022 across multiple countries. We examined cause-specific excess mortality during 2020–2022 in Denmark, Finland, Norway, and Sweden—four countries with similar demographics and welfare provisions, wh

In this work, numerical investigations were performed using large eddy simulations and validated against detailed measurements in the CeCOST swirl stabilised burner. Both cold and reactive flow have been studied and the model has shown a good agreement with experiments. The verification of the model was done using the LES index of quality and a single grid estimator. The cold flow simulations pred

Farmers are key to preserving and restoring semi-natural pastures (SNPs) while maintaining their environmental and cultural significance. To support these efforts, it is essential to create favorable conditions that encourages voluntary participation of farmers in agri-environment-climate measures (AECM) for SNP management. This study aims to assess acceptability of contract attributes within AECM

Introduction: The alarming global increase in lifestyle-related disorders such as obesity and type 2 diabetes mellitus (T2DM) has increased during the last several decades. Poor dietary choices significantly contribute to this increase and prevention measures are urgently needed. Dietary intake of bioactive compounds found in foods are linked to a decrease likelihood of these disorders. For t

Phocaeicola dorei and Phocaeicola vulgatus are very common and abundant members of the human gut microbiome and play an important role in the infant gut microbiome. These species are closely related and often confused for one another; yet, their genome comparison, interspecific diversity, and evolutionary relationships have not been studied in detail so far. Here, we perform phylogenetic analys

Background. Pain is common in Parkinson's disease (PD) and impairs quality of life. The King's PD pain questionnaire (KPPQ) is a standardized, reliable, and valid self-administered questionnaire for screening of pain in PD. We developed a linguistically validated German version of the KPPQ and applied it to a cohort with fluctuating PD. Methods. The interculturally adapted German translation was p

Objectives: To explore the population-based risk factors for genital herpes in women and examine whether genital herpes occurs at higher rates in women diagnosed with cervical neoplasia and common urogenital infections. Methods: An open cohort study consisting of 4,097,075 women ≥15 years of age in Sweden (2002-2018). The outcome was genital herpes diagnosis. The predictor variables were sociodemo

opus: Op. 91bsubtitle: Bossainstrumentation: trumpet, brass quintetdedicated to: Håkan Hardenbergercommissioner: gift for Håkan's 50th birthday from the composer

Snowpack atop sea ice plays a vital role in the Arctic heat and energy balance by reducing the energy transfer between the atmosphere and the ocean. This study presents an improved snow depth retrieval model over Arctic multiyear ice (MYI) from the Microwave Radiometer Imager (MWRI) data of the Fengyun-3 (FY-3) series satellites using the optimal machine learning approach identified. Validation ag

Tree growth and longevity trade-offs fundamentally shape the terrestrial carbon balance. Yet, we lack a unified understanding of how such trade-offs vary across the world's forests. By mapping life history traits for a wide range of species across the Americas, we reveal considerable variation in life expectancies from 10 centimeters in diameter (ranging from 1.3 to 3195 years) and show that the p

Background: Pain is one of the most frequently reported symptoms and often one of the first subjective symptoms in patients with systemic lupus erythematosus (SLE). A previous study indicated that most patients with SLE reported low levels of SLE-related pain. However, a subgroup of patients reported high levels of pain ≥40 mm (0-100 mm) and had a substantial symptom burden in terms of fatigue, an

roduction of biomass for bioenergy on marginal land has been promoted to decrease the use of non-renewable energy without competing with food production. Previous estimates of marginal land and abandoned farmland in Sweden available for bioenergy production are based on general statistics and assumptions but lack in-depth analyses of potential alternative land-use values. Easily accessible public

Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences many cellular processes, including cytoskeleton stability, mechanosensing, metabolism, and proteasome function. While most studies have primarily focused on GFAP