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CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma.

Post-translational modification of different proteins via direct ubiquitin attachment is vital for mediating various cellular processes. CYLD, a deubiquitination enzyme, is able to cleave the polyubiquitin chains from the substrate, and to regulate different signaling pathways. Loss, or reduced expression, of CYLD is observed in different types of human cancer, such as hepatocellular carcinoma (HC

A micro-spectroscopy study on the influence of chemical residues from nanofabrication on the nitridation chemistry of Al nanopatterns

We applied spatially resolved photoelectron spectroscopy implemented with an X-ray photoemission electron microscopy (XPEEM) using soft X-ray synchrotron radiation to identify the compositional and morphological inhomogeneities of a SiO2/Si substrate surface nanopatterned with Al before and after nitridation. The nanofabrication was conducted by a polymethylmethacrylate (PMMA)-based e-beam lithogr

A re-examination of the Fisher effect using an alternative approach

The Fisher Effect (FE) is of fundamental importance in financial markets. The majority of previous studies have not managed to obtain the expected one-for-one reaction of the nominal interest rate to the inflation rate. The aim of this article is to reinvestigate the FE for the USA and the UK using a case-wise bootstrap approach developed by Hatemi-J and Hacker (2005). This method is robust to non

EVpedia: A Community Web Portal for Extracellular Vesicles Research.

Extracellular vesicles are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for extracellular vesicle-related publications and vesicular components are currently challenging.

Large Scale Biobanking of Blood – The Importance of High Density Sample Processing Procedures

We introduce a novel automated sample-processing concept that will be of mandatory importance to proteomics and future clinical research, performing patient studies from resulting blood fractions in various disease areas. Biobank storage of small sample volumes allows for high replicate numbers to be processed and aliquoted, where each sample aliquot can be used for a dedicated clinical analysis a

Adaptations for nocturnal and diurnal vision in the hawkmoth lamina.

Animals use vision over a wide range of light intensities, from dim starlight to bright sunshine. For animals active in very dim light the visual system is challenged by several sources of visual noise. Adaptations in the eyes, as well as in the neural circuitry, have evolved to suppress the noise and enhance the visual signal, thereby improving vision in dim light. Among neural adaptations, spati

Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion.

The trigeminal ganglion (TG) plays a central role in cranial pain. Administration of complete Freund's adjuvant (CFA) into the temporomandibular joint (TMJ) elicits activation of TG. Kynurenic acid (KYNA) is an endogenous excitatory amino acid receptor blocker, which may have an anti-inflammatory effect. We hypothesize that KYNA may reduce CFA-induced activation within the TG.

Diffractive Higgsstrahlung

We consider single-diffractive (SD) Higgs production in association with heavy flavor in proton-proton collisions at the LHC. The main focus of our study is a reliable estimate of SD/inclusive ratio, not a precision computation of the cross sections. The calculations are performed within the framework of the phenomenological dipole approach, which includes by default the absorptive corrections, i.

Understanding econo-political risks: impact of sanctions on an automotive supply chain

Purpose - The purpose of this paper is to introduce econo-political risks (EPRs) to supply chains (SCs). Based on case data from an automotive SC, this research identifies the mechanisms through which a subset of EPRs influences Sc operations and outcomes. Design/methodology/approach - An exploratory case study method is employed for theory development. Interviews with SC professionals of three ca

How are immigrant background and gender associated with the utilisation of psychiatric care among adolescents?

PURPOSE: To investigate how parental country of birth and individual gender affect utilisation of psychiatric care in adolescents. METHODS: On the basis of data from the Longitudinal Multilevel Analysis in Scania database, the article employs logistic regression to analyse the utilisation of psychiatric care among adolescents aged 13-18 (n = 92203) who were living in the southern Swedish county of

WTS-2 b: a hot Jupiter orbiting near its tidal destruction radius around a K dwarf

We report the discovery of WTS-2 b, an unusually close-in 1.02-d hot Jupiter (M-P = 1.12M(J), R-P = 1.30R(J)) orbiting a K2V star, which has a possible gravitationally bound M-dwarf companion at 0.6 arcsec separation contributing similar to 20 per cent of the total flux in the observed J-band light curve. The planet is only 1.5 times the separation from its host star at which it would be destroyed

Anchored LH2 Complexes in 2D Polarization Imaging.

Protein is a soft material with inherently large structural disorder. Consequently, the bulk spectroscopies of photosynthetic pigment protein complexes provide averaged information where many details are lost. Here we report spectroscopy of single light-harvesting complexes where fluorescence excitation and detection polarizations are both independently rotated. Two samples of peripheral antenna (

Identification of signal bias in the variable flip angle method by linear display of the algebraic Ernst equation

A novel linear parameterization for the variable flip angle method for longitudinal relaxation time T1 quantification from spoiled steady state MRI is derived from the half angle tangent transform, t, of the flip angle. Plotting the signal S at coordinates x=St and y=S/t, respectively, establishes a line that renders signal amplitude and relaxation term separately as y-intercept and slope. This re

Acceptable noise level (ANL) with Danish and non-semantic speech materials in adult hearing-aid users

Objective: The acceptable noise level (ANL) test is used for quantification of the amount of background noise subjects accept when listening to speech. This study investigates Danish hearing-aid users' ANL performance using Danish and non-semantic speech signals, the repeatability of ANL, and the association between ANL and outcome of the international outcome inventory for hearing aids (IOI-HA).

Spatial distribution of erosion and deposition during a glacier surge: Bruarjokull, Iceland

Time-series of digital elevation models (DEMs) of the forefield of the Bruarjokull surge-type glacier in Iceland were used to quantify the volume of material that was mobilized by the 1963-1964 surge. The DEMs were produced by stereophotogrammetry on aerial photographs from before the surge (1961) and after (1988 and 2003). The analysis was performed on two DEMs of Difference (DoDs), i.e., a 1961-

Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent.

We investigated (a) if activation of the mitogen activated protein kinase (MAPK) pathway was linked to the stress activated protein kinase (SAPK) pathway and (b) if JNK was required for activation of c-Jun in Schwann cells of rat sciatic nerve following injury. To this aim, ERK1/2 and the transcription factors c-Jun and ATF-3 were studied by immunohistochemistry in segments of transected nerves. W