Estrogens are important regulators of bone mass and their effects are mainly mediated via estrogen receptor(ER)α.CentralERα exertsaninhibitoryroleonbonemass.ERα ishighlyexpressedinthearcuate (ARC) and the ventromedial (VMN) nuclei in the hypothalamus. To test whether ERα in proopiomelanocortin (POMC) neurons, located in ARC, is involved in the regulation of bone mass, we used mice lacking ERα expr

Many experiments have shown that loss of biodiversity reduces the capacity of ecosystems to provide the multiple services on which humans depend. However, experiments necessarily simplify the complexity of natural ecosystems and will normally control for other important drivers of ecosystem functioning, such as the environment or land use. In addition, existing studies typically focus on the diver

Thermosensitive Transient Receptor Potential (TRP) channels are believed to respond to either cold or heat. In the case of TRP subtype A1 (TRPA1), there seems to be a species-dependent divergence in temperature sensation as non-mammalian TRPA1 is heat-sensitive whereas mammalian TRPA1 is sensitive to cold. It has been speculated but never experimentally proven that TRPA1 and other temperature-sens

The cadastre of King Valdemar is one of the most investigated and debated written sources that survive from early medieval Denmark. In particular, the detailed list of revenue from Halland has attracted a lot of attention. Despite this, many unanswered questions still remain. This article attempts to address some of these queries.

Kalamang is Papuan language spoken by 150 people in the east of Indonesia. The language is threatened with extinction. This thesis treats mainly phonetics and phonology, but also gives an overview over parts of Kalamang grammar. Pronouns, demonstratives, nominal morphology and some basic syntax are discussed, among other things. The thesis also includes a word list with 700 Kalamang lexemes, and a

AbstractOut-of-hospital cardiac arrest is a devastating manifestation of coronary artery disease. For patients who are initially resuscitated and are admitted to an intensive care unit, mortality is high. Roughly half of all patients die, primarily due to neurological injury. In recent years, some improvement in outcomes has been seen, perhaps in some part due to interventions performed in hospita

The underlying mechanisms for the effect of proteins on appetite regulation, especially in presence of variable macronutrient composition, are not fully elucidated. The present study investigated the absorption kinetics of proteins after co-ingestion with the other macronutrients and examined the impact of circulating amino acids on appetite and satiety-related gut hormones. A randomized, within-s

This paper investigates the place of animals in the contemporary Swedish human cemetery. It does this by looking at how animals are admitted to cemeteries – alive and dead, above and below ground, physically as well as symbolically. The aim is to shed light on the various ways that animals are experienced and treated in the cemetery, and to explore how this both reflects our changing attitudes to

Background Following oesophagectomy, a major surgical procedure, it is known that patients suffer from severely reduced quality of life and have an unmet need for postoperative support. Still, there is a lack of research testing interventions aiming to enhance the patients’ life situation after this surgical procedure. Aim The aim of the study was to evaluate the effect of a nurse led telephone su

This work presents a digital calibration technique in continuous-time (CT) delta-sigma (Δ Σ) analog to digital converter. The converter is clocked at 144 MHz with a low oversampling ratio (OSR) of only 8. Dynamic element matching is not efficient to linearize the digital to analog converter (DAC) when the OSR is very low. Therefore, non-idealities in the outermost multi-bit feedback DAC are measur

We have sequenced fusA, the gene coding for elongation factor G (EF-G), in 18 different mutants of Salmonella typhimurium selected as fusidic acid resistant (FuR). In addition, we have sequenced two previously described FuR mutants from Escherichia coli. In all cases, the resistance is due to a mutation in one of three separate regions in fusA. The three clusters of mutant sites superimpose on reg

We report a novel mutation, C1066U in 16S rRNA which was selected for resistance to spectinomycin, an antibiotic which inhibits ribosomal translocation. The minimal inhibitory concentration (MIC) of spectinomycin determined for this mutant (15 micrograms/ml) is greater than with the wild-type plasmid (5 micrograms/ml) but lower than with the well known C1192U mutation (> 80 micrograms/ml). The C10

Background: Extracellular vesicles (EV) are nano-sized membranous structures released from most cells. They have the capacity to carry bioactive molecules and gene expression signals between cells, thus mediating intercellular communication. It is believed that EV confer protection after ischemic preconditioning (IPC). We hypothesize that myocardial ischemic preconditioning will lead to rapid alte

Primary productivity of terrestrial vegetation is expected to increase under the influence of increasing atmospheric carbon dioxide concentrations ([CO2]). Depending on the fate of such additionally fixed carbon, this could lead to an increase in terrestrial carbon storage, and thus a net terrestrial sink of atmospheric carbon. Such a mechanism is generally believed to be the primary global driver