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Concurrent Circular Reference Attribute Grammars (Extended Version)

Reference Attribute Grammars (RAGs) is a declarative executable formalism used for constructing compilers and related tools. Existing implementations support concurrent evaluation only with global evaluation locks. This may lead to long latencies in interactive tools, where interactive and background threads query attributes concurrently.We present lock-free algorithms for concurrent attribute eva

Adaptive mechanisms in the hypoxic tumor microenvironment. Functional role of proteoglycans and identification of potential treatment targets

Cancer cells reside in a complex microenvironment comprising stromal cells and immune cells embedded in an extracellular matrix (ECM). Early on in tumor progression, cells reach a critical volume beyond which blood supply is impaired, leading to a decrease in oxygen levels (hypoxia) and nutrient supply. This situation triggers a stress response characterized by a metabolic switch to glycolysis, wh

Body Height and Incident Risk of Venous Thromboembolism : A Cosibling Design

BACKGROUND: Body height has been associated with an increased risk of venous thromboembolism (VTE), but the association can be confounded with shared familial factors (genetic/environmental). A cosibling design is useful for deeper understanding about the relationship between VTE and height.METHODS AND RESULTS: From Swedish national registry databases, we used a corelative design with full sibling

High Risk of Venous Thromboembolism in Klinefelter Syndrome

BACKGROUND: Klinefelter syndrome (KS) is the most common sex chromosome disorder. The genetic background is the extra X chromosome. Venous thromboembolism (VTE) has been observed among KS patients. The aim of the present study was to examine whether KS is associated with VTE.METHODS AND RESULTS: We followed up all hospital in- and outpatients (N=1085) in Sweden with a diagnosis of KS between Janua

On safety ontology : A cross-section analysis of incident investigations in a public healthcare system

Background:Due to new legislation in 2011 and 2013, the Swedish public healthcare system has undergone change as regards incident reporting and supervision. Focus has turned to learning from adverse events and sharing this learning with actors within the system. The aim of this study was to explore with what underlying safety ontology adverse events in the incident reporting system are investigate

Flow Counting Using Realboosted Multi-sized Window Detectors

One classic approach to real-time object detection is to use adaboost to a train a set of look up tables of discrete features. By utilizing a discrete feature set, from features such as local binary patterns, efficient classifiers can be designed. However, these classifiers include interpolation operations while scaling the images over various scales. In this work, we propose the use of real value

Prioriteringar i folkvandringens tid

Den som har det tryggt och bra flyr inte. Vi flyr från svält, fattigdom och politiskt förtryck. När konferensen om prioriteringar i folkvandringens tid hölls 2016 förväntades mellan 70000 och 140000 flyktingar komma till Sverige. Några av dem hade varit med om hemskheter som nog flera av oss i Sverige har svårt att föreställa sig. Många var/är i stort behov av vård på grund av fysisk eller psykisk

Autoimmune diseases and venous thromboembolism : a review of the literature

Venous thromboembolism (VTE) is major health problem and is sometimes complicated by lethal pulmonary embolism (PE). Disturbances of the coagulation and anticoagulation systems are important risk factors for VTE. Comparative studies suggest that coagulation and innate immunity have a shared evolutionary origin. It is therefore unsurprising that the immune and coagulation systems are linked, with m

Increased hepatic fatty acid polyunsaturation precedes ectopic lipid deposition in the liver in adaptation to high-fat diets in mice

OBJECTIVE: We monitored hepatic lipid content (HLC) and fatty acid (FA) composition in the context of enhanced lipid handling induced by a metabolic high-fat diet (HFD) challenge and fasting.MATERIALS AND METHODS: Mice received a control diet (10% of kilocalories from fat, N = 14) or an HFD (45% or 60% of kilocalories from fat, N = 10 and N = 16, respectively) for 26 weeks. A subset of five mice r

Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by (13)C Magnetic Resonance Spectroscopy

Type 2 diabetes (T2D) is associated with deterioration of brain structure and function. Here, we tested the hypothesis that T2D induces a reorganization of the brain metabolic networks that support brain function. For that, alterations of neuronal and glial energy metabolism were investigated in a T2D model, the Goto-Kakizaki (GK) rat. (13)C magnetic resonance spectroscopy in vivo at 14.1 T was us