SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo. Although mutations in Sugct lead to Glutaric Aciduria Type 3 disease in humans, patients remain largely asymptomatic despite high levels of glutarate in the urine. To study the disease mechanism, we generated SugctKO mice and uncovered imb

In this work, the possibility of using planar droplet sizing (PDS) based on laser-induced fluorescence (LIF) and Mie scattering was investigated within the framework of measuring the droplet Sauter mean diameter (SMD) of direct-injection spark-ignition (DISI) spray systems. For this purpose, LIF and Mie signals of monodisperse fuel droplets produced by a droplet generator were studied at engine re

Root-induced channels are the primary controlling factors for rapid movement of water and solute in forest soils. To explore the effects of root distribution on preferential flow during rainfall events, deciduous (Quercus variabilis BI.) and coniferous forest (Platycladus orientalis (L.) Franco) sites were selected to conduct dual-tracer experiments (Brilliant Blue FCF and Bromide [Br-]). Each plo

Concerns have been raised about the potential adverse effects of liberalizing trade in services under the GATS framework on equity, costs, distribution, availability of services and sovereignty of governments in defining their national objectives. These concerns have been voiced in poor countries in case of such social service sectors as health and education. Critics have stressed the need for an

Experimental aerosol generation methods aim to represent natural processes; however, the complexity is not always captured and unforeseen variability may be introduced into the data. The current practices for natural and experimental aerosol generation techniques are reviewed here. Recommendations for best practice are presented, and include characterization of starting material and spray fluid, r

The problems of neutrino masses, matter-antimatter asymmetry, and dark matter could be successfully addressed by postulating right-handed neutrinos with Majorana masses below the electroweak scale. In this work, leptonic decays of W bosons extracted from 32.9 fb−1 to 36.1 fb−1 of 13 TeV proton–proton collisions at the LHC are used to search for heavy neutral leptons (HNLs) that are produced throug

At the conference of the International Society for the Scholarship of Teaching and Learning (ISSOTL) in Bergen, Norway (October 2018), we were privileged to have heard a lecture by Elizabeth Minnich, “People who are not thinking are capable of anything: What are students learning, how are students learning it, and does it make them better people?”In November 2018, as a follow-up to the lecture, Ch

In this paper we present fully decentralized methods for calculating an approximate zero- forzing (ZF) equalizer in a large intelligent surface (LIS). A LIS is intended for wireless communication and facilitates unprecedented MU- MIMO performance, far superior to that of Massive MIMO. Antenna modules in the grid connect to their neighbors to exchange messages of information needed for interference

In this paper, full-and sub-structure characteristic modes (CMs) are explored through the effect of coupling between the target and background structures. The eigenvalues and eigen-current distributions of the first few modes are compared for different coupling levels in the numerical example. Similarities and differences between the two types of CMs in specific conditions are revealed, paving the

This paper reports on research undertaken to identify generic and specific barriers to reuse of electrical and electronic equipment (EEE). Thirty semi-structured interviews were conducted with experts from across the value chain including product designers, manufacturers, users and waste managers as well policy makers and academics. The interviews sought to examine perceived and real barriers to r

Testosterone deficiency in males is associated with serious comorbidities such as cardiovascular disease, diabetes type two, and also an increased risk of premature death. The pathogenetic mechanism behind this association, however, has not yet been clarified and is potentially bidirectional. The aim of this clinical trial was to gain insight into the short-term effect of changes in testosterone o

The Theory of Characteristic Modes has been shown capable of facilitating the development of many high-quality antennas through providing the characteristic modes (CMs) inherent to a structure. The CMs will change if the structure is altered; this property has been used to adapt terminal antennas, enabling good MIMO performance in compact structures. Previously these designs focused on altering th

Background: Demographic changes combined with costly technological progress put a financial strain on the healthcare sector in the industrialized world. Hence, there is a constant need to develop new cost-effective treatment procedures in order to optimize the use of available resources. As a response, the concept of a Mobile Geriatric Team (MGT) has emerged not only nationally but also internatio

Background: Citral is commonly used as a fragrance and flavor material and consists of the aldehydes geranial and neral. Citral is included in fragrance mix (FM) II. Geranial and neral have also been identified in autoxidation of geraniol, a fragrance compound present in FM I. Objectives: To study contact allergy to citral, geranial, and neral, and concomitant reactivity to oxidized geraniol and f

BackgroundGenesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, th

Background: Allergic contact dermatitis (ACD) caused by hexavalent chromium, Cr(VI), is often severe and difficult to treat. The most common source of exposure to Cr(VI) in Sweden used to be cement, and more recently leather. The contact allergy can be diminished or inhibited if the exposure is decreased or ceases. Barrier creams against different kinds of allergens have been investigated for thei