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Physiological model controlled sweating thermal manikin: can it replace human subjects?
Beyond whole grain: The European HEALTHGRAIN project aims at healthier cereal foods
Cereal foods are an important source of carbohydrates and dietary fiber in our diet. Epidemiological evidence increasingly demonstrates that a diet rich in whole grain is protective against development of diet-related disorders such as cardiovascular disease and type 2 diabetes. The majority of cereal foods today, however, are made from refined wheat flour. The grain processing industry therefore
MM/GBSA and LIE estimates of host-guest affinities: dependence on charges and solvation model.
The affinities of two sets of guest-host systems were estimated using the popular end-point methods MM/GBSA (molecular-mechanics with generalised Born and surface-area solvation) and LIE (linear interaction energy). A set of six primary alcohols that bind to α-cyclodextrin (α-CD) and a set of eight guest molecules to cucurbit[8]uril (CB8) were considered. Three different charge schemes were used t
Phenotypic and genetic characterisation of bacterial sexually transmitted infections in Bissau, Guinea-Bissau, West Africa: a prospective cohort study
BACKGROUND: Knowledge regarding characteristics and transmission of Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium and antibiotic resistance in N gonorrhoeae in Guinea-Bissau, West Africa, is entirely lacking. OBJECTIVES: To characterise N gonorrhoeae, C trachomatis and M genitalium samples from Guinea-Bissau and to define bacterial populations, possible transmission chains
”På velociped öfver Öresund!” Gränspraktiker och kulturella föreställningar om cykellandet Danmark.
De homine : människouppfattningen i äldre luthersk tradition. Nytryck
Experimentally Determined Human Respiratory Tract Deposition of Airborne Particles at a Busy Street
Traffic is one of the major sources of harmful airborne particles worldwide. To relate exposure to adverse health effects it is important to determine the deposition probability of the inhaled particles in the human respiratory tract. The size-dependent deposition of 12-580 nm particles was measured with a novel setup in 9 healthy subjects breathing by mouth on the windward side of a busy street i
Effects of Selenium Status and Polymorphisms in Selenoprotein Genes on Prostate Cancer Risk in a Prospective Study of European Men
Background: Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considerin
Filmen om Zidane – en modell för kulturstudier
Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age 72
Background: Familial adenomatous polyposis (FAP) is typically characterized by multiple colonic polyps and frequent extracolonic features. Whereas the number of colonic polyps has been linked to the APC gene mutation, possible genotype-phenotype correlations largely remain to be defined for the extracolonic manifestations. Methods: Full genomic sequencing combined with multiplex ligation-dependent
Polsk Marialyrik
Recension av en doktorsavhandling i polsk litteratur, försvarad vid Uppsala universitet i december 2011.
HIF1 alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation
Background: Neuroendocrine (NE) differentiation in prostate cancer has been correlated with a poor prognosis and hormone refractory disease. In a previous report, we demonstrated the presence of immunoreactive cytoplasmic hypoxia inducible factor 1 alpha (HIF1 alpha), in both benign and malignant NE prostate cells. HIF1 alpha and HIF1 beta are two subunits of HIF1, a transcription factor important
Dynamic Optimization in JModelica.org
We present the open-source software framework in JModelica.org for numerically solving large-scale dynamic optimization problems. The framework solves problems whose dynamic systems are described in Modelica, an open modeling language supported by several different tools. The framework implements a numerical method based on direct local collocation, of which the details are presented. The implemen
Microcontact imprinting based surface plasmon resonance (SPR) biosensor for real-time and ultrasensitive detection of prostate specific antigen (PSA) from clinical samples
Prostate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate cancer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via
Evacuation models are running out of time
The representation of crowd movement in existing evacuation models is typically based on data collected in the 1950s to 1980s, i.e., data that are more than 40 years old. Since the 1970s, population characteristics have changed dramatically around the world. Reports show that the percentage of elderly and obesity rates have increased significantly and this trend is predicted to continue into the f
A theoretical model of the evolution of maternal effects under parent-offspring conflict
The evolution of maternal effects on offspring phenotype should depend on the extent of parent-offspring conflict and costs and constraints associated with maternal and offspring strategies. Here, we develop a model of maternal effects on offspring dispersal phenotype under parent-offspring conflict to evaluate such dependence. In the absence of evolutionary constraints and costs, offspring evolve
Av HFD avgjorda mål om samma eller likartad verksamhet
The Potential Demise of a Population of Adders (Vipera berus) in Smygehuk, Sweden
In 1999 and 2004, we published reports on how the introduction of 20 males into a severely inbred and isolated population of Adders (Vipera berus) halted its decline towards extinction. The introduction significantly enhanced the population's genetic variability, which resulted in a dramatic increase in offspring viability and a rapid increase in numbers. Unfortunately, recently a new and unpreced
Link between Cathodoluminescence and Electron Energy Loss Spectroscopy and the Radiative and Full Electromagnetic Local Density of States
Electron energy loss spectroscopy (EELS) and cathodoluminescence (CL) have proved during the past few years to be tremendous tools to study surface plasmons in metallic nanoparticles, thanks to an extremely high spatial resolution combined with a broad spectral range. Despite their apparent close resemblance, qualitative differences between EELS and CL have been theoretically as well as experiment