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Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyte nuclear factor 4alpha (HNF4alpha) (the MODY1 gene) with risk for type 2 diabetes. We attempted to reproduce this putative association by genotyping 11 single nucleotide polymorphism (SNPs) spanning the HNF4a coding region and the P2 promoter in >3,400 patients and control subjects from Sweden, Fin

Specialnummer om filosofi i Lund

Cricopharyngeal myotomy was performed on 60 patients suffering from cervical oesophageal dysphagia. Of 37 that had a Zenker diverticulum the diverticulum was excised in 24. All patients were free of symptoms on post-operative follow-up at 2-10 years. In 10 patients with a cervical oesophageal web or postcricoid stenosis, the ability to eat normal food was restored. In 7 of 9 patients with neuromus

Cerebral function was measured with a neuropsychological test battery before, during, and after insulin-induced hypoglycaemia (blood glucose approximately 2.0 mmol l-1) in 10 male Type 1 diabetic patients (age 20-43 years, duration of diabetes 14 (2-30) years) and in 12 normal men. There were no group differences in neuropsychological results at normal glucose levels. Significant effects of hypogl

This paper contains an overview of the homogenization of anisotropic materials at fixed frequency using the concept of two-scaled convergence. The homogenized electric and magnetic parameters, the relative permittivity, and the relative permeability are found by suitable averages of the solution of a local problem in the unit cell. A comparison between the exact homogenization method presented in

Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result of cleavage by a protease, and the latent form, which is also inactive, can arise due to a mutation

Recent experiments have identified peptides that adhere to GaAs and Si surfaces. Here, we use all-atom Monte Carlo simulations with implicit solvent to investigate the behavior in aqueous solution of four such peptides, all with 12 residues. At room temperature, we find that all four peptides are largely unstructured, which is consistent with experimental data. At the same time, we find that one o

In this paper, we present a comparison between the reduced mechanisms obtained through a computational singular perturbation method (CSP) and the reduced mechanisms obtained through a lifetime analysis based only on the diagonal elements of the Jacobian matrix and a species sensitivity The two methods are used for the analysis of autoignition, which is an interesting test situation because of the

This paper describes a fast algorithm for topology independent tracking of moving interfaces under curvature- and velocity field-dependent speed laws. This is usually done in the level set framework using the narrow-band algorithm, which accurately solves the level set equation but is too slow to use in real-time or near real-time image segmentation applications. In this paper we introduce a fast

Popular Abstract in Swedish Länder som strävar efter att kvalificera sig för medlemskap i Europeiska unionen måste genomföra omfattande reformer under kort tid. Som en effekt av anpassningsprocessen till unionens regelverk och politiska, ekonomiska och administrativa kriterier omstruktureras statsapparaten. Detta gäller inte minst i de kandidatländer som samtidigt genomgår radikala transformationsIt is generally recognized that the EU accession process has profound effects on state transformation in the postcommunist applicant countries. A key problem of postcommunism has been a weak ability to implement public policy. This study explores how efforts to fulfill EU conditionality may influence implementing capacity. Firstly, it advances a theoretical framework for this purpose, focusing on

High-spin states in Lu-165 were populated in the La-139(Si-30, 4n) reaction at a beam energy of 152 MeV and gamma-ray coincidences were measured with the EUROBALL spectrometer array. Nine new rotational bands were discovered, known band structures were considerably extended and many inter-band transitions were found. Structures with normal deformation coexist with bands associated with the strongl

I tidigare forskningsprojekt har vattenavvisande impregneringar studerats genom litteraturstudier och laboratorieprovningar. För att skapa en bättre helhet har dessa studier kompletterats med fullskaleförsök under en 10-årsperiod. Fullskaleförsöken har avsett både vattenavvisande fasadimpregnering och injicering mot uppstigande markfukt i murverk.

Åren 1999–2003 avled drygt 3 000 patienter under intensivvård södra sjukvårdsregionen. I endast 6 procent av fallen (174 patienter) hade man konstaterat total hjärninfarkt med medicinska möjligheter till organdonation. Samtycke till organdonation gavs i drygt hälften av fallen. En motsvarande registrering kan i kvalitetssäkringsprogrammet för intensivvården (PASIVA) bli en rikstäckande kvalitetssäA complete registration of all deceased patients at intensive care units in the Southern Health region of Sweden has shown that 3,114 patients died during the five years from 1999 to 2003. Only 174 cases (5.6 per cent) were classified as potential organ donors according to the definition of total brain infarction (brain death) without medical contra-indications against organ donation. Consent for