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Circulating Tumor Cell Count as an Indicator of Treatment Benefit in Advanced Prostate Cancer
Lundadagarna i Historisk Geologi och Paleontologi XII 17–18th of March
On the Role of the Rank Condition in CCE Estimation of Factor-Augmented Panel Regressions
A popular approach to factor-augmented panel regressions is the common correlatedeffects (CCE) estimator of Pesaran (Estimation and inference in large heterogeneous panels with a multifactor error structure. Econometrica 74, 967–1012, 2006). This paper points to a problem with the CCE approach that appears in the empirically relevant case when the number of factors is strictly less than the number
Green and blue water demand from large-scale land acquisitions in Africa
In the last decade, more than 22 million ha of land have been contracted to large-scale land acquisitions in Africa, leading to increased pressures, competition, and conflicts over freshwater resources. Currently, 3% of contracted land is in production, for which we model site-specific water demands to indicate where freshwater appropriation might pose high socioenvironmental challenges. We use th
Development of a moisture safe connection for stud walls
Moisture penetration around windows and doors is a problem with serious consequences for stud walls and is a common problem regardless of facade systems. The problem has received considerable focus in recent times, as buildings using ETICS (External thermal insulation composite systems) on stud walls have been damaged by penetrating water. In the present paper a robust moisture safe prefabricated
Useful Cinema and the Concept of the Auteur
Common cancers share familial susceptibility : Implications for cancer genetics and counselling
Background It has been proposed that cancer is more common in some families than in others, but the hypothesis lacks population level support. We use a novel approach by studying any cancers in large threegeneration families and thus are able to find risks even though penetrance is low. Methods Individuals in the nation-wide Swedish Family- Cancer Database were organised in three generations and t
Proposed ICDRG Classification of the Clinical Presentation of Contact Allergy
The International Contact Dermatitis Research Group proposes a classification for the clinical presentation of contact allergy. The classification is based primarily on the mode of clinical presentation. The categories are direct exposure/contact dermatitis, mimicking or exacerbation of preexisting eczema, multifactorial dermatitis including allergic contact dermatitis, by proxy, mimicking angioed
Architecture of the human mitochondrial iron-sulfur cluster assembly machinery
Fe-S clusters, essential cofactors needed for the activity of many different enzymes, are assembled by conserved protein machineries inside bacteria and mitochondria. As the architecture of the human machinery remains undefined, we co-expressed in Escherichia coli the following four proteins involved in the initial step of Fe-S cluster synthesis: FXN42-210 (iron donor); [NFS1]·[ISD11] (sulfur dono
Deciphering the structure of the West Greenland marine food web using stable isotopes (δ13C, δ15N)
The Arctic is facing major environmental changes impacting marine biodiversity and ecosystem functioning. One way of assessing the responses of an ecosystem to these changes is to quantitatively study food web dynamics. Here, we used stable isotope (δ15N and δ13C) analyses of 39 Arctic marine species to investigate trophic relationships and isotopic niches of the West Greenland food web in 2000–20
Knowledge and utilization of sexual and reproductive healthcare services among Thai immigrant women in Sweden
Background: Migration from Thailand to Sweden has increased threefold over the last 10 years. Today Thailand is one of the most common countries of origin among immigrants in Sweden. Since the year 2000, new HIV cases are also more prevalent among Thai immigrants compared to other immigrant nationalities in Sweden. The purpose of this study was to investigate the association between knowledge and
Implementation of Models of Care for secondary osteoporotic fracture prevention and orthogeriatric Models of Care for osteoporotic hip fracture
As the world's population ages, the prevalence of osteoporosis and its resultant fragility fractures is set to increase dramatically. This chapter focuses on current frameworks and major initiatives related to the implementation of fracture liaison services (FLS) and orthogeriatrics services (OGS), Models of Care designed to reliably implement secondary fracture prevention measures for individuals
Contact allergy in atopic individuals in relation to allergen-specific immunotherapy
Background: Type I sensitizations and atopic dermatitis (AD) often appear in the same patient. Beneficial effects of allergen-specific immunotherapy (ASIT) in patients with bothADand type I allergies have been reported. The predisposing role of AD to the development of type IV sensitization is discussed. Whether ASIT for type I allergy also influences type IV allergies is unknown. Objectives: To c
Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion
Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes. The cellular mechanisms behind the development of diabetes by statins are elusive. Here we have treated mice on normal diet (ND) and high fat diet (HFD) with rosuvastatin. Under ND rosuvastatin lowered blood glucose through improved
Preface
Detection of glaucoma progression by perimetry and optic disc photography at different stages of the disease : Results from the Early Manifest Glaucoma Trial
Purpose: To compare the earliest detection of progression in visual fields and monoscopic optic disc photographs at different stages of manifest glaucoma. Methods: This study evaluated 306 eyes in 249 patients with manifest open-angle glaucoma included in the Early Manifest Glaucoma Trial (EMGT). All patients in the trial were followed up regularly by standard automated perimetry and monoscopic op