Background: Multiple myeloma (MM) patients who have progressed following treatment with both bortezomib and lenalidomide have a poor prognosis. In this late stage, other effective alternatives are limited, and patients in Sweden are often left with best supportive care. Pomalidomide is a new anti-angiogenic and immunomodulatory drug for the treatment of MM. Our objective was to evaluate the cost e

The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adhere

Conditions for nurses’ daily patient education work are unclear and require clarification. The aim was to develop and validate the Nurses’ Patient Education Questionnaire, a questionnaire that assesses nurses’ perceptions of appropriate conditions for patient education work: what nurses say they actually do and what they think about what they do. The questionnaire was developed from a literature r

Incorrectly labelled cosmetic wet wipes can cause severe eczema, leading to major concerns amongst the public. Read below what was revealed by chemical analysis in a laboratory in Malmö, Sweden.

For a map (Formula presented.) with an invariant measure (Formula presented.), we study, for a (Formula presented.)-typical (Formula presented.), the set of points (Formula presented.) such that the inequality (Formula presented.) is satisfied for infinitely many (Formula presented.). We give a formula for the Hausdorff dimension of this set, under the assumption that (Formula presented.) is piece

To improve the stability and reproducibility of laser wakefield accelerators and to allow for future applications, controlling the injection of electrons is of great importance. This allows us to control the amount of charge in the beams of accelerated electrons and final energy of the electrons. Results are presented from a recent experiment on controlled injection using the scheme of colliding p

In order to reduce the vibration transmission in multi-storey wood buildings, it is common to insert viscoelastic elastomer materials between parts of the buildings. The studies presented here investigate to which extent different design choices for the elastomer layers affect the isolation of low-frequency vibrations (0-100 Hz). A finite element model of two storeys of a multi-storey wood buildin

BACKGROUND: Cadmium is a non-essential toxic metal with multiple adverse health effects. Exposure in the general population occurs by smoking and diet. Cadmium in erythrocytes is a valid biomarker of exposure and body burden of cadmium.OBJECTIVES: We aimed to identify genetic variants related to concentrations of cadmium in erythrocytes.METHODS: Erythrocyte cadmium was analyzed in 4432 individuals

Wind turbine towers are large structures designed to withstand the unique loading conditions imposed on them by the turbine's nacelle and dynamic forces from the rotating blades. Observations and noise measurements of a particular wind turbine showed high noise levels at approximately 48 Hz, which could not be explained from the usual known potential noise sources. Correlated far field noise measu

The dynamics of electron acceleration driven by laser wakefield inside a 30.5 mm long dielectric capillary tube is analyzed using radiation emitted in the x-ray range. 3D particle-in-cell simulations, performed with parameters close to the experimental ones, show that in long plasmas, the accelerated electrons catch up and finally overrun the driving laser owing to a higher velocity of the electro

Low frequency vibrations in footbridges is a cause of annoyance for pedestrians crossing the bridge. Bagers bro, a footbridge built in Malmö (Sweden) had several constraints in the physical design that caused the first eigenmode of the bridge to be at 1.8Hz which is a severe problem for pedestrians. Therefore the bridge was fitted with tuned mass dampers to mitigate the vibration problem. To evalu

In the last few years, technologies for broadband delivery over copper have dealt with increased capacity demands by using high frequencies and transmitter coordination, also known as vectoring. At the same time, to provide high capacity mobile broadband, operators have resorted to small cells. The work compiled into this dissertation covers both vectoring in traditional and future wireline servic

We present a non-contact platelet functional analysis platform based on acoustic trapping of platelet clusters and activation monitoring using impedance spectroscopy. The system was characterized using polystyrene particles and human platelets. The system was also capable of transferring platelets from plasma into a controlled buffer. Trapped platelets were activated using 20 and 40 μM TRAP and th

Studies of nanoconfined circular DNA are of interest both from a biological as well as a fundamental polymer physics perspective. We here present the use of nanofluidic channels as a tool for comparing statics and dynamics of the linear and circular configuration of the same DNA molecule.

The theme of innovation (understood as the introduction of new products, processes, or organizational forms in the marketplace) is interdisciplinary in nature. Economic geographers started participating in the field early, but scholars from fields such as economics and innovation studies have also contributed to understanding the geography of innovation. Core topics have been to examine how innova

BACKGROUND: Chronic leg ulcers remain a challenge to the treating physician. Such wounds often need skin grafts to heal. This necessitates a readily available, fast, simple, and standardized procedure for grafting.OBJECTIVES: The aim of this work was to test a novel method developed for outpatient transplant procedures.METHODS: The procedure employs a handheld disposable dermatome and a roller min

Objective. To describe the effects of implementing a robotic surgical program within gynecologic oncology and gynecology at a tertiary referral hospital. Design: Prospective study. Setting: University Hospital, Lund and Lund University, Sweden. Methods. Based on prospective data retrieved for all patients, we evaluated intraoperative times, estimated blood loss, rate of conversion and rate of intr

Field choice was recorded during counts of geese in South-west Scania, South Sweden in autumn (October and November) and in winter (January), 1977/1978-2011/2012. Sugar beet spill was the most important field type in autumn and during the last ten years also in winter. Bean Geese Anserfabalis used this food source when the study started while Canada Geese Branta canadensis, Greylag Geese Anser ans