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National Cancer Database: The Past, Present, and Future of the Cancer Registry and Its Efforts to Improve the Quality of Cancer Care

Published 7 November 2019 The National Cancer Database (NCDB) continues to evolve to improve the care of the cancer patient. Over the last 30 years, the NCDB has compiled nearly 40 million patient records submitted by over 1500 hospitals across the country. Addressing new challenges, the NCDB is transitioning to ensure data flow is more timely and data collection more efficient. New publication in

https://www.lupop.lu.se/article/national-cancer-database-past-present-and-future-cancer-registry-and-its-efforts-improve-quality - 2025-01-08

Early-life inequalities and biological ageing: a multisystem Biological Health Score approach in Understanding Society

Published 8 November 2019 Social position is known to play a role in the quality of ageing, notably through the stimulation/dysregulation of key physiological systems in response to external stresses. Using data from one wave of Understanding Society including 9088 participants, we defined, as an extension of the allostatic load, a synthetic Biological Health Score (BHS) capturing the wear-and-tea

https://www.lupop.lu.se/article/early-life-inequalities-and-biological-ageing-multisystem-biological-health-score-approach - 2025-01-08

Development of a multinational registry of pediatric deceased organ donation activity

Published 11 November 2019 There are no currently agreed upon international standards for reporting of pediatric deceased organ donation activity. This leads to difficulty in comparisons between jurisdictions for both researchers and policy stakeholders. The goal of this project was to develop and test a standardized registry for pediatric deceased donation activity. New publication in Pediatric T

https://www.lupop.lu.se/article/development-multinational-registry-pediatric-deceased-organ-donation-activity - 2025-01-08

Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates

Published 12 November 2019 The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2025-01-08

Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

Published 13 November 2019 Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.go

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2025-01-08

Population-Based Observational Studies in Oncology: Proceed With Caution

Published 14 November 2019 A principle goal of research in Oncology is to determine the optimal treatment for our patients. This often takes the form of comparing 2 existing therapies to one another to determine which is superior, or to introduce a new therapy and determine if it is superior or noninferior to the existing standard of care. New publication in Seminars in Radiation Oncology

https://www.lupop.lu.se/article/population-based-observational-studies-oncology-proceed-caution - 2025-01-08

Validation of diagnosis codes to identify side of colon in an electronic health record registry

Published 15 November 2019 ICD codes are a highly reliable indicator of tumor location when the specific location code is entered in the EHR. However, non-specific side of colon ICD codes are present for a sizable minority of patients, and structured data alone may not be adequate to support testing of some research hypotheses. New publication in BMC Medical Research Methodology

https://www.lupop.lu.se/article/validation-diagnosis-codes-identify-side-colon-electronic-health-record-registry - 2025-01-08