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When Is a Complete-Case Approach to Missing Data Valid? The Importance of Effect-Measure Modification

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 29 May 2021 When estimating causal effects, careful handling of missing data is needed to avoid bias. Complete-case analysis is commonly used in epidemiologic analyses. Previous work has shown that covariate-stratified effect estimates from complete-case analysis are unbiased when missingness is independent of the outcome cond

https://www.lupop.lu.se/article/when-complete-case-approach-missing-data-valid-importance-effect-measure-modification - 2025-04-01

Probabilistic Quantification of Bias to Combine the Strengths of Population-Based Register Data and Clinical Cohorts—Studying Mortality in Osteoarthritis

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 30 May 2021 We propose combining population-based register data with a nested clinical cohort to correct misclassification and unmeasured confounding through probabilistic quantification of bias. We have illustrated this approach by estimating the association between knee osteoarthritis and mortality. Read the paper at https:/

https://www.lupop.lu.se/article/probabilistic-quantification-bias-combine-strengths-population-based-register-data-and-clinical-1 - 2025-04-01

Infosäk

Published 3 May 2018 A platform for safe handling of data at the medical faculty Infosäk will shortly publish complete information about the project. Meanwhile, you can read more here.

https://www.lupop.lu.se/article/infosak - 2025-04-01

Methodological Issues in Population-Based Studies of Multigenerational Associations

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 31 May 2021 Photo: flickr / Mitchell Joyce Laboratory-based animal research has revealed a number of exposures with multigenerational effects—ones that affect the children and grandchildren of those directly exposed. An important task for epidemiology is to investigate these relationships in human populations. Read the paper a

https://www.lupop.lu.se/article/methodological-issues-population-based-studies-multigenerational-associations - 2025-04-01

Multiple-Imputation Variance Estimation in Studies With Missing or Misclassified Inclusion Criteria

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 1 June 2021 Photo: Pixabay / Gerd Altmann In observational studies using routinely collected data, a variable with a high level of missingness or misclassification may determine whether an observation is included in the analysis. In settings where inclusion criteria are assessed after imputation, the popular multiple-imputatio

https://www.lupop.lu.se/article/multiple-imputation-variance-estimation-studies-missing-or-misclassified-inclusion-criteria - 2025-04-01

On the Causal Interpretation of Rate-Change Methods: The Prior Event Rate Ratio and Rate Difference

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 2 June 2021 Photo: Pixabay / Gerd Altmann A growing number of studies use data before and after treatment initiation in groups exposed to different treatment strategies to estimate “causal effects” using a ratio measure called the prior event rate ratio (PERR). Here, we offer a causal interpretation for PERR and its additive s

https://www.lupop.lu.se/article/causal-interpretation-rate-change-methods-prior-event-rate-ratio-and-rate-difference - 2025-04-01

What Now? Epidemiology in the Wake of a Pandemic

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 2 June 2021 Image from pixabay / pearson0612 The coronavirus disease 2019 (COVID-19) pandemic and the coming transition to a postpandemic world where COVID-19 will likely remain as an endemic disease present a host of challenges and opportunities in epidemiologic research. Read the paper at https://academic.oup.com/aje/article

https://www.lupop.lu.se/article/what-now-epidemiology-wake-pandemic - 2025-04-01

Reducing Bias Due to Exposure Measurement Error Using Disease Risk Scores

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 3 June 2021 Suppose that an investigator wants to estimate an association between a continuous exposure variable and an outcome, adjusting for a set of confounders. If the exposure variable suffers classical measurement error, in which the measured exposures are distributed with independent error around the true exposure, then

https://www.lupop.lu.se/article/reducing-bias-due-exposure-measurement-error-using-disease-risk-scores - 2025-04-01

Simulation as a Tool for Teaching and Learning Epidemiologic Methods

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 4 June 2021 Photo: Kennet Ruona In aspiring to be discerning epidemiologists, we must learn to think critically about the fundamental concepts in our field and be able to understand and apply many of the novel methods being developed today. We must also find effective ways to teach both basic and advanced topics in epidemiolog

https://www.lupop.lu.se/article/simulation-tool-teaching-and-learning-epidemiologic-methods - 2025-04-01

Factorial Mendelian randomization: using genetic variants to assess interactions

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 5 June 2021 Photo: Pixabay / Arek Socha Factorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a factorial Mendelian randomization analysis. Read

https://www.lupop.lu.se/article/factorial-mendelian-randomization-using-genetic-variants-assess-interactions - 2025-04-01

Bias factor, maximum bias and the E-value: insight and extended applications

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 6 June 2021 Unmeasured confounding can bias the relationship between exposure and outcome. Sensitivity analyses generate bias-adjusted measures but these are not much used; this may change with the availability of the E-value (for evidence for causality in observational studies), appealing for its ease of calculation. Read the

https://www.lupop.lu.se/article/bias-factor-maximum-bias-and-e-value-insight-and-extended-applications - 2025-04-01

Reference-adjusted and standardized all-cause and crude probabilities as an alternative to net survival in population-based cancer studies

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 7 June 2021 Photo: Pixabay / Colin Behrens We illustrate the method and some potential choices using data from England for men diagnosed with melanoma. Various marginal measures are presented and compared. Read the paper at https://academic.oup.com/ije/article/49/5/1614/5896134

https://www.lupop.lu.se/article/reference-adjusted-and-standardized-all-cause-and-crude-probabilities-alternative-net-survival - 2025-04-01

PhD position in Economic History: Neighborhood effects over the life course

Published 27 May 2021 Fotograf: Håkan Röjder The PhD position is linked to the research project The long reach of the neighborhood: Health, education and earnings in Landskrona, Sweden, 1904-2015, funded by Handelsbankens forskningsstiftelser. The PhD student will work in this project in collaboration with other project members and will be affiliated with the Centre for Economic Demography at LUSE

https://www.lupop.lu.se/article/phd-position-economic-history-neighborhood-effects-over-life-course - 2025-04-01

Reflection on modern methods: planned missing data designs for epidemiological research

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 16 June 2021 Photo: Pixabay / Gerd Altmann This paper describes the multiform, wave-missing and two-method designs, including their benefits, their impact on bias and power, and other factors that must be taken into consideration when implementing them in an epidemiological study design. Read the paper at https://academic.oup.

https://www.lupop.lu.se/article/reflection-modern-methods-planned-missing-data-designs-epidemiological-research - 2025-04-01

UN Climate Report on April 4th: “What matters now is zero emissions”

By jessika [dot] sellergren [at] lth [dot] lu [dot] se (Jessika Sellergren) - published 1 April 2022 “Zero emissions are what counts if we are going to be able to live up to the Paris Agreement goal of limiting global warming,” says Lars J. Nilsson. Photo: Unsplash. In connection with a new report on measures to mitigate climate change, researchers at Lund University in Sweden see some hopeful sig

https://www.cec.lu.se/article/un-climate-report-april-4th-what-matters-now-zero-emissions - 2025-04-01

Henrik Smith new member of the Swedish Climate Policy Council

By anna_maria [dot] erling [at] cec [dot] lu [dot] se (Anna Maria Erling) - published 21 April 2022 Henrik Smith. Photo: Johan Persson. The Swedish Government has today appointed Henrik Smith, professor in animal ecology at Lund University, as a new member of the Climate Policy Council. Henrik Smith works at the Center for Environmental and Climate Science (CEC) and the Department of Biology in Lu

https://www.cec.lu.se/article/henrik-smith-new-member-swedish-climate-policy-council - 2025-04-01

50 millions to research about finance and biodiversity

By anna_maria [dot] erling [at] cec [dot] lu [dot] se (Anna Maria Erling) - published 4 May 2022 The BIOPATH consortium consists of a carefully composed team of research specialists in sustainable finance and biodiversity as well as influential partners from industry, the financial system and public authorities. The research programme ”Pathways towards an efficient alignment of the financial syste

https://www.cec.lu.se/article/50-millions-research-about-finance-and-biodiversity - 2025-04-01

National symposium in Norrköping focuses on climate research

By anna_maria [dot] erling [at] cec [dot] lu [dot] se (Anna Maria Erling) - published 4 May 2022 The sympsoium will focus on climate change in a Swedish context. What is happening to the climate and what role does climate research play in society? The strategic research areas MERGE and BECC, the Bolin Centre for Climate Research and SMHI are together arranging a climate symposium in Norrköping on

https://www.cec.lu.se/article/national-symposium-norrkoping-focuses-climate-research - 2025-04-01

How is nature to be valued? New report on the way from IPBES

By anna_maria [dot] erling [at] cec [dot] lu [dot] se (Anna Maria Erling) - published 5 July 2022 In a new report IPBES consider what values that can be put on nature, and what methods exist to calculate such a values. Photo: Istock. Is it possible to put a value on nature and the vital ecosystem services it provides for us? What are the pros and cons of different valuation models? These are the k

https://www.cec.lu.se/article/how-nature-be-valued-new-report-way-ipbes - 2025-04-01