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Parametric design systems serve as powerful assistive technologies in the design process by aiding the generation of a vast number of design alternatives. However, with their focus on low-level engineering and structural form, parametric systems do not automatically fulfil cognitively founded people-centred behavioural design criteria. We propose a precedent-based design approach for parametric sy
Generalist parasites must adapt to diverse host environments to ensure their survival and transmission. These adaptations can involve fixed genetic responses, transcriptional plasticity, or epigenetic mechanisms. The avian malaria parasite Plasmodium homocircumflexum offers an ideal model for studying transcriptional variation across hosts. We experimentally inoculated P. homocircumflexum into dif
Policing roles require specific work-related characteristics (WRCs) critical for effective performance. This study identifies key WRCs for various roles within the Swedish Police—patrol officers, criminal investigators, Special Weapons and Tactics (SWAT) Teams, police chiefs, and negotiators—by analyzing data from 425 active-duty officers (30% response rate). We use the Occupational Information Ne
At the close of the sixteenth century, Archduke Charles of Inner Austria determined that only his eldest son was to succeed him. Barring his younger sons from rule was a break with the Habsburg tradition of partible inheritance and would prove to be an important step towards the introduction of primogeniture. How did the Austrian Habsburgs deal with this change in succession practice? This contrib
The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri
We investigate the persistence of embedded eigenvalues for a class of magnetic Laplacians on an infinite cylindrical domain. The magnetic potential is assumed to be C2 and asymptotically periodic along the unbounded direction of the cylinder, with an algebraic decay rate toward a periodic background potential. Under the condition that the embedded eigenvalue of the unperturbed operator lies away f
Importance: The etiologic interrelationship of 4 rare/controversial psychotic disorders (delusional disorder [DD], acute psychoses [AP], psychosis not otherwise specified [PNOS], and schizoaffective disorder [SAD]) is poorly understood. Objective: To assess levels of the family genetic risk score (FGRS) for schizophrenia (SZ), bipolar disorder (BD), and major depression (MD) in individuals with DD
When electrically stimulated, electroactive polymers (EAPs) respond with mechanical deformation. The goal of this work is to design electrode and EAP layouts simultaneously in structures using density-based, multi-material topology optimization. In this novel approach the layout of electrodes and EAP material are not given a priori but is a result from the topology optimization. Material interpola
This paper presents the exploration of GPU-accelerated block-wise decompositions for zero-forcing (ZF) based QR and Cholesky methods applied to massive multiple-input multiple-output (MIMO) uplink detection algorithms. Three algorithms are evaluated: ZF with block Cholesky decomposition, ZF with block QR decomposition (QRD), and minimum mean square error (MMSE) with block Cholesky decomposition. T
The lifelong risk of stroke following adverse pregnancy outcomes, and potential causality, are unknown. This study examined five major adverse pregnancy outcomes and long-term risk of stroke in a large population-based cohort. Methods A national cohort study was conducted of all 2 201 393 women with a singleton delivery in Sweden during 1973–2015, followed up for stroke through 2018. Cox regressio
Effective governance and management of ecosystem functions to promote human well-being and social equity require a clear understanding of supply and demand dynamics. While this is widely acknowledged in assessments of ecosystem services, it remains largely neglected for ecosystem disservices, despite many ecosystem functions generating both services (benefits) and disservices (costs) depending on
The adsorption and activation energetics underpinning small molecule conversion on heterogeneous (photo)-electrocatalysts are intrinsically tied to catalyst surface properties. Absent compositional characterization techniques with sufficient interface sensitivity, however, (photo)-electrochemical performance can be misinterpreted in the context of bulk or near-surface material properties. Here we
Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and periprosthetic bone remodelling of a short stem with and without a collar, using radiostereometric analysis (RSA) to measure implant migration and dual-energy X-ray absorptio
In this paper I’m concerned with the functional role of singular terms and how it can be used to construct a pragmatist theory of what it takes to understand reference. I argue that there are, at least, two distinct functions which singular terms fulfil, what I will call the talking-about and picking-out functions respectively. Both are, in one sense, ways that a term aids our understanding by spe
Background Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient ciliary airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship to diagnostic findings and clinical phenotypes. Methods Genetic variants and clinical findings (a
High-order harmonic generation (HHG) in gases has been studied for almost 40 years under many different conditions, varying the laser wavelength, intensity, focusing geometry, target design, gas species, etc. However, no systematic investigation of the effect of the pulse duration has been performed despite its expected impact on phase-matching of the high-order harmonics. Here, we develop a compa
While delays in human-robot encounters can harm perceptions of competence, they can also enhance engagement and relatability, making timing a crucial factor in the design of robot behaviors for effective human-robot interaction. Previous research has primarily focused on how robots’ pauses or errors impact perceptions of competence, but it has not adequately addressed the complexity of timing in s
Hydrogen energy technologies are anticipated to play a fundamental role in securing a decarbonised energy future. While the deployment of low-carbon hydrogen energy systems remains nascent and is subject to a range of techno-economic constraints, potential scalability will also hinge on social acceptance. In response, this study draws on extensive national survey data to derive a comprehensive typ
