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Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP and Wanker EE.Molecular Cell 71 (5): 675-688.(2018)AbstractSelf-propagating, amyloidogenic mutant huntingtin (mHTT) agg

https://www.huntington-research.lu.se/mhtt-seeding-activity-marker-disease-progression-and-neurotoxicity-models-huntingtons-disease - 2025-11-25

Karlsson J, Petersén Å, Gidö G, Wieloch T and Brundin P.Cell Transplantation 14: 301-309 (2005)AbstractAround 80-95% of the immature dopaminergic neurons die when embryonic ventral mesencephalic tissue is transplanted. Cell death occurs both during the preparation of donor tissue and after graft implantation, but the effect of combining successful neuroprotective treatments before and after transp

https://www.huntington-research.lu.se/combining-neuroprotective-treatment-embryonic-nigral-donor-tissue-mild-hypothermia-graft-recipient - 2025-11-25

Araujo IM, Xapelli S, Gil JM, Mohapel P, Petersén Å, Pinheiro PS, Malva JO, Bahr BA, Brundin P and Carvalho CM.Neuroreport 16: 393-396 (2005)AbstractOveractivation of N-methyl-D-aspartate receptors is known to mediate excitotoxicity due to excessive entry of calcium, leading to the activation of several calcium-dependent enzymes. Calpains are calcium-activated proteases that appear to play a role

https://www.huntington-research.lu.se/proteolysis-nr2b-calpain-hippocampus-epileptic-rats - 2025-11-25

Papalexi E, Persson A, Björkqvist M, Petersén Å, Woodman B, Bates GP, Sundler F, Mulder H, Brundin P and Popovic N.European Journal of Neuroscience 22: 1541-1546 (2005)AbstractReductions in testosterone and luteinizing hormone levels and reduced sexual functions have been reported in Huntington's disease (HD) patients. Atrophy of the reproductive organs and loss of fertility have also been observe

https://www.huntington-research.lu.se/reduction-gnrh-and-infertility-r62-mouse-model-huntingtons-disease - 2025-11-25

Gil MAC J, Leist M, Popovic N, Brundin P and Petersén Å.BMC Neuroscience 5: 17 (2004)AbstractBACKGROUND:Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play important roles in the pathogenesis of HD. Since no effective treatment is available, this study was designed

https://www.huntington-research.lu.se/asialoerythropoetin-not-effective-r62-line-huntingtons-disease-mice - 2025-11-25

Petersén Å, Puschban Z, Lotharius J, NicNiocaill B, Wiekop B, O´Connor, WT and Brundin P.Neurobiology of Disease 11: 134-146 (2002)AbstractThe present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxy

https://www.huntington-research.lu.se/evidence-dysfunction-nigrostriatal-pathway-r61-line-transgenic-huntingtons-disease-mice - 2025-11-25

Petersén Å, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N.Experimental Neurology 175: 297-300 (2002)AbstractA transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with

https://www.huntington-research.lu.se/maintenance-susceptibility-neurodegeneration-following-intrastriatal-injections-quinolinic-acid-new - 2025-11-25

Petersén Å and Brundin P.International Review of Neurobiology 53: 315-339 (2002) SummaryThe Huntington's disease (HD) has stimulated novel clinical drug trials based on the ideas about mechanisms of cell death in the disorder. A recent study investigated the effects of remacemide and coenzyme Q on progression of symptoms in HD. These drugs are an N-methyl-d-aspartate (NMDA) antagonist and a mitoch

https://www.huntington-research.lu.se/huntingtons-disease-mystery-unfolds - 2025-11-25

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2025-11-25

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D.Human Molecular Genetics 10: 1243-1254 (2001)AbstractHuntington's disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown, although alterations in protein degradation are involved. To study intrinsic

https://www.huntington-research.lu.se/expanded-cag-repeats-exon-1-huntingtons-disease-gene-stimulate-dopamine-mediated-striatal-neuron - 2025-11-25

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, and Sulzer D.Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, SwedenBrain Research Bulletin 56(3-4): 331-335 (2001)AbstractIn hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) p

https://www.huntington-research.lu.se/brain-derived-neurotrophic-factor-inhibits-apoptosis-and-dopamine-induced-free-radical-production - 2025-11-25

The Translational Neuroendocrine Research Unit (TNU) is located in the Biomedical Center (BMC) in Lund in the south of Sweden.Our visiting address is Klinikgatan 32, building D, floor 11.How to get to LundFrom Copenhagen Airport (CPH)Copenhagen airport Kastrup is Denmark's international airport, and is much closer to Lund than the airports in Stockholm. Here you have direct flights from most Europ

https://www.huntington-research.lu.se/visit-us - 2025-11-25

Congratulation and welcome to the Master of Science Programme in Welfare Policies and Management (SAWEM) and the course Welfare Regimes in Transition. Comparative Perspectives on Policies, Management and Reform (WPMP01) We are happy to welcome you to the Department of Political Science, Department of Sociology and School of Social Work at Lund University  Compulsory introductory and registration m

https://www.svet.lu.se/en/education/new-student-admission-information/msc-welfare-policies-and-management - 2025-11-25

CONGRATULATIONS AND WELCOME TO THE COURSE FKVB22 We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully.  Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggi

https://www.svet.lu.se/en/education/new-student-admission-information/peace-and-conflict-studies-war-and-peace-western-balkans-75-credits - 2025-11-25

Congratulations and welcome to the course STVN22 We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully.  Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggi

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-policy-processes-actors-causes-and-consequences - 2025-11-25

Congratulations and welcome to the course STVN14 We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully. Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggin

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-methodology-15-credits - 2025-11-25

Congratulations and welcome to the course STVP30 We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully.  Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggi

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-european-governance - 2025-11-25

English summary Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington's disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene.However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features.The hypothalamus has

https://www.huntington-research.lu.se/psychiatric-and-metabolic-disturbances-experimental-models-huntingtons-disease - 2025-11-25

Welcome to your 6th and final semester in the BIDS-programme, major Political Science! Please see the information below that you need to know in order to secure our offer. It is important that you read the information thoroughly. Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer

https://www.svet.lu.se/en/education/new-student-admission-information/bsc-development-studies-political-science-major - 2025-11-25

Petersén began medical school at Lund University (LU) in 1994 and started her PhD training in 1997. She received her PhD in experimental neuroscience in 2001 at the Faculty of Medicine at LU with Prof. Patrik Brundin as supervisor with a PhD thesis on Huntington’s disease (HD). She became an MD 2004 and a Reader (docent) in Neuroscience in 2006.Petersén started her research group TNU when she rece

https://www.huntington-research.lu.se/team/asa-petersen-md-phd - 2025-11-25