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Baldo B, Cheong RY, Petersén ÅPLoS One 9(10) (2014)AbstractPsychiatric and metabolic features appear several years before motor disturbances in the neurodegenerative Huntington’s disease (HD), caused by an expanded CAG repeat in the huntingtin (HTT) gene. Although the mechanisms leading to these aspects are unknown, dysfunction in the hypothalamus, a brain region controlling emotion and metabolism

https://www.huntington-research.lu.se/effects-deletion-mutant-huntingtin-steroidogenic-factor-1-neurons-psychiatric-and-metabolic - 2025-12-09

Soylu-Kucharz R, Khoshnan A and Petersén Å. bioRxiv 2021.04.08.438894; First published April 9, 2021. https://doi.org/10.1101/2021.04.08.438894 Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, and underlying mechanisms are not fully known. As the IKKβ/NF

https://www.huntington-research.lu.se/ikkb-signaling-mediates-metabolic-changes-hypothalamus-huntingtons-disease-mouse-model - 2025-12-09

Henningsen JB,  Soylu-Kucharz R, Björkqvist M and Petersén Å. Heliyon. 2021 Aug 14;7(8):e07808. doi: 10.1016/j.heliyon.2021.e07808. eCollection 2021 Aug. Abstract Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. T

https://www.huntington-research.lu.se/effects-excitotoxicity-hypothalamus-transgenic-mouse-models-huntington-disease - 2025-12-09

Learn more from these short films where Åsa Petersén talks about cognitive symptoms and behavioural changes and psychiatric in Huntington's disease. Published by courtesy of Riksförbundet Huntingtons Sjukdom. All films are in Swedish. To view the Swedish subtitles, please click the button "CC" in the control bar (third from right) and choose "Svenska". Åsa Petersén about cognitive symptoms.   Åsa

https://www.huntington-research.lu.se/cognitive-symptoms-and-behavioural-changes - 2025-12-09

Gabery S, Kwa JE, Cheong RY, Baldo B, Ferrari Bardile C, Tan B, McLean C, Georgiou-Karistianis N, Poudel GR, Halliday G, Pouladi MA and Petersén Å.  Acta Neuropathologica. 142(5): 791-806 (2021) doi: 10.1007/s00401-021-02362-8. Abstract Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. The typical motor symptoms have been a

https://www.huntington-research.lu.se/early-white-matter-pathology-fornix-limbic-system-huntington-disease - 2025-12-09

Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Petersén Å, Lindholm D and Korhonen L.Human Molecular Genetics 23: 5928-5939 (2014)AbstractHuntington's disease (HD) is an autosomal inherited neurological disease caused by a CAG repeat expansion in the first exon of huntingtin gene encoding for the huntingtin protein (Htt). In HD there is an accumulation of in

https://www.huntington-research.lu.se/ubiquitin-specific-protease-14-reduces-cellular-aggregates-and-protects-against-mutant-huntingtin - 2025-12-09

Dickson E, Soylu-Kucharz R , Petersén Å and Björkqvist M. Mol Metab. 2022 Mar;57:101439. doi: 10.1016/j.molmet.2022.101439. Epub 2022 Jan 7. Abstract Objective In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progress

https://www.huntington-research.lu.se/hypothalamic-expression-huntingtin-causes-distinct-metabolic-changes-huntingtons-disease-mice - 2025-12-09

Soylu-Kucharz R, Khoshnan A and Petersén Å. iScience 2022 Jan 19;25(2):103771. doi: 10.1016/j.isci.2022.103771. eCollection 2022 Feb 18. Abstract Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Metabolic changes are associated with HD progression, but underlying mechanisms are not fully known. As the IKKβ/NF-κB pathway is an

https://www.huntington-research.lu.se/ikkb-signaling-mediates-metabolic-changes-hypothalamus-huntingtons-disease-mouse-model-0 - 2025-12-09

Dickson E, Sai Dwijesha A, Andersson N, Lundh S, Björkqvist M, Petersén Å and Soylu-Kucharz R. Frontiers in Neuroscience. 2022 Nov 3;16:1027269. doi: 10.3389/fnins.2022.1027269. PMID: 36408416; PMCID: PMC9671106. Abstract Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative diso

https://www.huntington-research.lu.se/microarray-profiling-hypothalamic-gene-expression-changes-huntingtons-disease-mouse-models - 2025-12-09

Petersén Å1 and Kirik D2.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Journal of Clinical Investigation 17:1-3 (2014)AbstractA common form of the hyperkinetic movement disor

https://www.huntington-research.lu.se/twisting-mice-move-dystonia-field-forward - 2025-12-09

Hellem MNN, Cheong RY, Tonetto S, Vinther-Jensen T, Hendel RK, Larsen IU, Nielsen TT, Hjermind LE, Vogel A, Budtz-Jørgensen E, Petersén Å and Nielsen JE. Parkinsonism and Related Disorders. 99: 23-29 (2022).  Abstract Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social c

https://www.huntington-research.lu.se/decreased-csf-oxytocin-relates-measures-social-cognitive-impairment-huntingtons-disease-patients - 2025-12-09

Bergh S, Cheong R Y, Petersén Å and Gabery S. Front. Mol. Neurosci., 14 September 2022; Sec. Molecular Signalling and Pathways; doi.org/10.3389/fnmol.2022.984317   Abstract Neurodegenerative disorders (NDDs) such as Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable popu

https://www.huntington-research.lu.se/oxytocin-huntingtons-disease-and-spectrum-amyotrophic-lateral-sclerosis-frontotemporal-dementia - 2025-12-09

Furby H, Moore S, Nordstroem A-L, Houghton R, Lambrelli D, Graham S, Svenningsson P and Petersén Å. Journal of Neurology. 270(2): 864-876 (2023) doi:10.1007/s00415-022-11418-y. Abstract Background: Huntington's disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. Objective:

https://www.huntington-research.lu.se/comorbidities-and-clinical-outcomes-adult-and-juvenile-onset-huntingtons-disease-study-linked - 2025-12-09

On this page, the Gender and Politics Research Group (GPRG) is presented, including the conveners, researchers in the group, and upcoming seminars. About the groupThe Gender and Politics research group brings together lecturers and researchers who think of gender as a central analytical lens through which power, institutions, norms and identities should be studied.Gender is increasingly prominent

https://www.svet.lu.se/en/research/research-groups/gender-and-politics-research-group - 2025-12-09

STVC75 – Bachelor course in Political science (7.5 credits). This course focuses on local politics and administration in democratic systems in a comparative perspective. The course includes web-based elements in collaboration with other European universities. Empirically, the approach is a comparative perspective on the organizing principles and primary activities of the local public sector as wel

https://www.svet.lu.se/en/education/international-opportunities/exchange-students-coming-sweden/bachelor-courses/local-government-comparative-perspective - 2025-12-09

Autumn 2025 The Higher Research Seminar is the main collective seminar of the department. The research staff and invited national and international leading scholars present ongoing research and analyses of a broad range of exciting topics of relevance for Political Science. The seminar is held on Wednesdays 13.15 to 14.30 in Eden 367, unless otherwise indicated. PhD mid-term seminars 13:15 to 14:4

https://www.svet.lu.se/en/higher-research-seminar - 2025-12-09

De 5 vanligaste frågorna om kostregistreringen Hur loggar jag in? Det är raden med 3 stora bokstäver, 2 siffror och 1 liten bokstav (ex ABC12d) längst ner på den lilla etiketten som är BÅDE ditt användarnamn och lösenord.  Etiketten sitter på pappret med instruktioner som låg i kuvertet med allt material till kostdelen. Jag har varit på kalas/julbord/festival etc kan jag registrera ändå? Ja, det g

https://www.h2o.lu.se/kan-vatten-minska-risken-typ-2-diabetes/fragor-svar - 2025-12-09

 Är du intresserad? Kontakta oss på telefon eller e-mail enligt nedan.Anmälan görs via telefon +46 40 332022 eller mail till Klinisk forskningsenhet som kommer att kontakta dig för vidare information: medklinforsk [dot] sus [dot] malmo [at] skane [dot] se

https://www.h2o.lu.se/anmal-dig-har - 2025-12-09

En fjärdedel av Sveriges befolkning har för höga nivåer av hormonet vasopressin och har därför tre gånger så stor risk att utveckla typ 2-diabetes. Den vanligaste orsaken till högt vasopressin är ett lågt vätskeintag. Vasopressin kan enkelt sänkas genom att öka vattenintaget. Nu söker Lunds universitet och Region Skåne deltagare i åldern 20 till 75 år med ett lågt vätskeintag till en ny studie som

https://www.h2o.lu.se/kan-vatten-minska-risken-typ-2-diabetes - 2025-12-09

Over-indebtedness amongst young adults creates difficulties when entering adulthood and tends to be a long-term problem. Description “Over-indebtedness” indicates enduring difficulties to pay off debts and fixed expenses. During the 2010s, over-indebtedness has increased among Swedish households and manifested itself as a societal problem. Moreover, indebtedness increases among young people, both

https://www.soch.lu.se/en/research/research-areas/civil-society-and-social-movements/debt-young-adults-and-dimensions-guilt - 2025-12-09