There is an unmet clinical need to extract living circulating tumor cells (CTCs) for functional studies and in vitro expansion to enable drug testing and predict responses to therapy in metastatic cancer. Here, we present a novel two-step acoustophoresis (A2) method for isolation of unfixed, viable cancer cells from red blood cell (RBC) lysed whole blood. The A2 method uses an initial acoustofluid

Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public health challenge. As these diseases are difficult to diagnose clinically, biomarkers of underlying pathophysiology are playing an ever-increasing role in research, clinical trials, and in the clinical work-up of patients. Though cerebrospinal fluid (CSF) and positron emission tomography (PET)-based measures ar

We report angle-resolved measurements on photoelectrons emitted upon near-threshold two-photon double ionization (TPDI) of Kr irradiated by free-electron laser (FEL) pulses. These photoelectron angular distributions (PADs) are compared with the results of semirelativistic R-matrix calculations. As reported by Augustin et al. [Phys. Rev. A 98, 033408 (2018)10.1103/PhysRevA.98.033408], it is found t

Denna reflektion handlar om hur videoessän, som ett alternativ till mer traditionella examinationsformer, kan bidra till att utveckla studenters medie- och informationskunnighet. Videoessäns funktion i film- och medievetenskaplig utbildning presenteras. Därefter diskuteras det pedagogiska upplägget för kursen där videoessän ingick som examinationsmoment. En slutsats är att videoessän är en examina

Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. In the present study, we investigated whether transcriptional changes would be part of hypothalamic pathology induced by the disease-causing huntingtin (H

Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration summarizes the evidence linking AF to cognitive impairment and dementia. It provides guidance on the investigation and management of dementia in patients with AF on the basis of b

BackgroundHealth systems are based on 6 functions that need to work together at all times to effectively deliver safe and quality health services. These functions are vulnerable to shocks and changes; if a health system is unable to withstand the pressure from a shock, it may cease to function or collapse. The concept of resilience has been introduced with the goal of strengthening health systems

In this work we construct explicit complex-valued p-harmonic functions on the compact Riemannian symmetric spaces SU(n)/SO(n), Sp(n)/U(n), SO(2n)/U(n), SU(2n)/Sp(n). We also describe how the same can be manufactured on their non-compact symmetric dual spaces.

One of the main factors hampering the implementation in industry of transaminase-based processes for the synthesis of enantiopure amines is their often low storage and operational stability. Our still limited understanding of the inactivation processes undermining the stability of wild-type transaminases represents an obstacle to improving their stability through enzyme engineering. In this paper

Automated decision-making is prevalent in numerous areas of the public sector. Based on the results of a qualitative, event-based study of how robotic process automation (RPA) is discussed and implemented in social work in Sweden, two questions are answered in this paper: What actors, intentions and network formations appear in the dissemination of RPA in the management of applications for social

Background: The outcome in patients after surgery for acute type A aortic dissection without replacement of the part of the aorta containing the primary tear is undefined. Methods: Data of 1122 patients who underwent surgery for acute type A aortic dissection in 8 Nordic centers from January 2005 to December 2014 were retrospectively analyzed. The patients with primary tear location unfound, unkno

Om platser verkligen är av betydelse, vilket ekonomiska geografer anser, då måste de vara som mest betydelsefulla för de människor vars liv utspelar sig på dessa platser, och upplever världen, materiellt kan kulturellt, genom den. När en kris och efterföljande osäkerheter drabbar en plats så påverkar detta främst människorna som kallar denna platsen för sitt hem. Ibland till den grad att en del avIf places indeed matter, as economic geographers believe, then it must matter most to the people who live their everyday lives in these places and experience the world materially and socially through it. When a crisis hits and uncertainty ensues, it affects people who call these places home the most. So much so, that some of them might be willing to stake a claim on its recovery, and development t

With the goal to delevop the fabrication of a new type of Pt-nanoparticle carbon-support electrocatalyst, we investigate the carbon embedding of Pt cluster superlattices grown on the moiré of a monolayer of hexagonal boron nitride (h-BN) on Ir(111). Our combined scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS) study establishes conformal C embedding of the Pt clusters

Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and regulatory molecules and so act as a platform for signal transduction. They float freely within the liquid-disordered bilayer of cellular membranes and can cluster to form larger ordered domains. Alterations in lipid rafts are commonly found to be associated with the pathogenesis of several human diseases and

As a promising carbon-free fuel, iron powder can directly combust with air and has great potential to provide clean and high-grad heat for various applications. The combustion characteristics of iron particles are of great significance for developing iron combustion model, designing efficient combustor, and optimizing combustion technologies. In this work, the micro-explosion behavior of burning i

Background: The occupation-based intervention Balancing Everyday Life (BEL) was found effective under controlled conditions but should also be studied in a natural clinical practice context. Aim: The aim was to study the implementation process of BEL when provided in a multi-professional mental health team. The focus was particularly on how BEL was received and functioned. Methods: This qualitativ

Pedagogical translanguaging research often shows positive effects on student engagement and learning (e.g., García & Kleyn, 2016; Paulsrud, Rosén, Straszer & Wedin, 2018; Paulsrud, Tian & Toth, 2021). Given that each classroom is a unique sociocultural context (Byrnes, 2020), often exhibiting complex multi-causality (Baker & Wright, 2021), most of this research is qualitative in na