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The Cell Death Census 2024

Cell death plays a pivotal role in many physiological processes, such as cell homeostasis, embryonic development, immune defence and in the pathophysiology of numerous diseases, such as cancer, infections and degenerative diseases. However, the lack of a comprehensive and up-to-date resource on cell death regulators poses a significant challenge to researchers in the field. Existing databases are of

RadClim BSR – Towards a High-resolution Radar-based Precipitation Climatology for the Baltic Sea Region

Archived radar data has various applications, though it is often underutilised. Nevertheless, this information has the possibility to aid in the development of accurate and relevant climate adaptation tools, inform climate-resilient urban development strategies, and numerous other personal and societal applications. Our work in the RadClim Baltic Sea Region (BSR) project established the potential

An annotated high-content fluorescence microscopy dataset with 2 EGFP-Galectin-3-stained cells and manually labelled outlines

Many forms of bioimage analysis involve the detection of objects and their outlines. In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be detected are cells. In order to develop and benchmark algorithms and neural networks that can perform this task, high-quality datasets with annotate

Internal and external factors explaining variability in children’s word definition skills: A scoping review protocol

AbstractObjective: The objective is to provide a detailed protocol for a scoping review aimed at mapping and summarizing studies of word definition (WD) skills in children, in clinical and non-clinical populations. More specifically, the aim is to map which factors have been studied as associated with WD skills. Furthermore, the scoping review will summarize the methodological characteristics of t

Personalizing progressive changes to brain structure in Alzheimer's disease using normative modeling

INTRODUCTION: Neuroanatomical normative modeling captures individual variability in Alzheimer's disease (AD). Here we used normative modeling to track individuals’ disease progression in people with mild cognitive impairment (MCI) and patients with AD. METHODS: Cortical and subcortical normative models were generated using healthy controls (n ≈ 58k). These models were used to calculate regional z

Characteristic Modes of Nonreciprocal Systems

The scattering formulation of characteristic mode decomposition is utilized to extend modal analysis to lossless scatterers breaking time-reversal symmetry. This enables characteristic modes analysis on devices containing gyrotropic or moving media. The resulting nonreciprocity introduces features not observed in reciprocal scenarios, such as asymmetric phase progression in characteristic far fiel

Thought for food : the endothermic brain hypothesis

The evolution of whole-body endothermy occurred independently in dinosaurs and mammals and was associated with some of the most significant neurocognitive shifts in life's history. These included a 20-fold increase in neurons and the evolution of new brain structures, supporting similar functions in both lineages. We propose the endothermic brain hypothesis, which holds that elaborations in endoth

European Union Normative Positions, Resilience and Contestation : A Perceptual Approach

Positioned within a perceptual approach to European Union (EU) foreign policy, this article explores tensions relating to the resilience of the EU's normative identity, focusing on factors and explanations external to the EU. We engage with EU perceptions amongst external partners theorized as active agents/potential contributors to contestation processes. We focus on the perceived role of the EU

Study of degradation mechanisms in aqueous-processed Ni-rich cathodes for enhanced sustainability of batteries

Traditionally, Ni-rich-layered oxide cathodes for lithium-ion batteries are produced utilizing N-methyl-2-pyrrolidone (NMP)-processed casting. However, to avoid using the reprotoxic solvent NMP, aqueous processing becomes one of the options. In this study, H2O-processed LiNi0.8Mn0.1Co0.1O2 (NMC811) electrodes have been prepared to compare with the NMP-processed counterparts to investigate the degr

Associations between misfolded alpha-synuclein aggregates and Alzheimer's disease pathology in vivo

INTRODUCTION: We examined the relations of misfolded alpha synuclein (α-synuclein) with Alzheimer's disease (AD) biomarkers in two large independent cohorts. METHODS: We included Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably Two (BioFINDER-2) and Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 2315, cognitively unimpaired, mild cognitive impairment,

Subjective measurement of physical activity and sedentary behaviour in children and adolescents with cerebral palsy : a scoping review

Purpose: Physical activity is essential for maintaining overall health. Cost-effective and easily administered outcome instruments are valuable for clinical practice and large-scale population studies. The scoping review aimed to identify and map subjective instruments developed or validated to measure habitual physical activity and/or sedentary behaviour in children and adolescents with cerebral