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Equipment

In excess of our standard lab equipment we have some specialised machines for certain tests or imaging. IVIS-CTIn Vivo Imaging System Spectrum CT 3D The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. The preclinical models inc

https://www.tcr.lu.se/equipment - 2025-02-11

IVIS-CT

In Vivo Imaging System Spectrum CT 3D The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. The preclinical models includes oncology, toxicology, cardiovascular disease, neurological disorders, inflammation and other related dise

https://www.tcr.lu.se/equipment/ivis-ct - 2025-02-11

Kidney Cancer Research Group

PI Håkan Axelson Background Renal cell carcinomas (RCCs) are derived from the epithelial cells of the nephron. Although surgical resection of localized RCC is often curative, treatment of metastasized disease is very challenging as these tumors are virtually resistant to conventional radio- and chemotherapy.  During the last 20 years the genetic landscape of these tumors has been detailed. In para

https://www.tcr.lu.se/research-groups/kidney-cancer-research-group - 2025-02-11

MSOT

Preclinical Multispectral Optoacoustic Tomography Multispectral Optoacoustic Tomography is a powerful optoacoustic imaging system for small animal imaging. It acquires cross-sectional images from head to tail, with high resolution, in vivo and in real time. The machine is also equipped with ultrasound computed tomography for further insights. MSOT InVision 512-Echo Image rate: 10/2 fps (MSOT/US) S

https://www.tcr.lu.se/equipment/msot - 2025-02-11

Zeiss 710

Live Cell Inverted Confocal Microscope The Zeiss 710 confocal laser scanning microscopes scan samples sequentially point by point. The microscope combines high-resolution optical imaging with depth selectivity which allows us to do optical sectioning. The inverted microscope is equipped with motorized stage, heated incubator, controller regulating O2, CO2 and humidity. This allow longitudinal imag

https://www.tcr.lu.se/equipment/zeiss-710 - 2025-02-11

Accessibility report

We are continuesly working on the accessibility of this webpage. This document describes how well tcr.lu.se complies with the accessibility regulations, any known accessibility issues, and how you can report problems so that we can fix them. If you experience any issues visiting our site we ask that you please contact us and let us know: johanna.verngren@med.lu.se How accessible is tcr.lu.se?This

https://www.tcr.lu.se/accessibility-report - 2025-02-11

Breast/Lung cancer

PI Johan Staaf Breast Cancer researchBreast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. This heterogeneity translates into differences in clinical manifestation, patient therapies, and ultimately patient outcome. TNBC is a subgroup of breast cancer, representing ~10% of all cases (9% in Sweden 2015). To date, this patient subgroup has often had

https://www.tcr.lu.se/research-groups/breastlung-cancer - 2025-02-11

Translational Cancer Research

Our task is to understand the basic mechanisms behind tumor development. This understanding provides a basis for matching the right drug with the right patient and thereby offer better conditions for individualized treatment of cancer patients. The Division of Translational Cancer Research (TCR) was founded 2013 in conjunction with the formation of Lund University Cancer Center (LUCC) at Medicon V

https://www.tcr.lu.se/translational-cancer-research - 2025-02-11

Medical Molecular Biology

PI Yvonne Ceder Our researchOur research aims to deduce the role of microRNAs in prostate cancer initiation and progression. The focus of our research is on the miRNA regulation of the transient processes leading to tumor progression and metastases as the reversibility of this type of regulation present a possible interference option. To capture the dynamic events occurring as the tumour cells tra

https://www.tcr.lu.se/research-groups/medical-molecular-biology - 2025-02-11

Tumor Cell Biology

PI Christer Larsson Our researchOur aims are to identify and understand mechanisms regulating breast cancer cell death and how inflammatory signaling can be induced and influence breast cancer progression. We specifically study Smac mimetics, small molecules mimicking the effect of the pro-apoptotic protein Smac. We investigate determinants of Smac-responsiveness and ways to circumvent resistance

https://www.tcr.lu.se/research-groups/tumor-cell-biology - 2025-02-11

Immuno-Oncology Group

PI Charlotte Rolny ResearchOur research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. Our lab employs state-of-the-art molecular biology techniques, mouse mod

https://www.tcr.lu.se/research-groups/immuno-oncology-group - 2025-02-11

Selected publications

VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells.Banerjee K, Kerzel T, Bekkhus T, Ferreira de Souza S, Wallmann T, Wallerius M, Landwehr LS, Agardy DA, Schauer N, Malmerfeldt A, Bergh J, Bartish M, Hartman J, Östman A, Squadrito ML and Rolny C. Cell Reports. 2023 Dec 1;42(12):113507. doi: 10.1016/j.celrep.2023.113507  MNK2 governs the macrophage antiinflammatory phenotype.B

https://www.tcr.lu.se/research-groups/charlotte-rolny/selected-publications - 2025-02-11

Molecular Pediatric Oncology

PI Daniel Bexell Our researchOur research is about childhood cancer neuroblastoma. We work to understand the mechanisms leading to metastasis and treatment resistant relapse, and to test new treatment against aggressive neuroblastoma. Our projects encompass studies on basic tumor biology as well as preclinical and translational studies with the aim to find novel treatments. We perform molecular an

https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology - 2025-02-11

Seminar Katja Harbst

14 February 2025 13:15 to 14:00 | Seminar TCR-Oncology Friday Seminar SeriesHybrid: Bioforum and ZoomContinue discussions with fika served in the lunch room afterwards. About the eventLocation:BioforumContact:carina [dot] bernardo [at] med [dot] lu [dot] se Save the event to your calendar

https://www.tcr.lu.se/calendar/seminar-katja-harbst - 2025-02-11

Seminar Daniel Ehinger

21 March 2025 13:15 to 14:00 | Seminar TCR-Oncology Friday Seminar SeriesHybrid: Bioforum and ZoomContinue discussions with fika served in the lunch room afterwards. About the eventLocation:BioforumContact:elsa [dot] arbajian [at] med [dot] lu [dot] se Save the event to your calendar

https://www.tcr.lu.se/calendar/seminar-daniel-ehinger - 2025-02-11