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Extensive physiological integration in Carex arenaria and Carex disticha in relation to potassium and water availability

Physiological integration between ramets is beneficial when acquiring heterogeneously distributed resources, and is hypothesized to occur when the benefits of resource sharing outweigh the costs. Our aim was to investigate if resource availability affected physiological integration in Carex arenaria and Carex disticha. Ramet systems were grown in high potassium and high water (K+ W+), high K and l

The IgD C(H)1 region contains the binding site for the human respiratory pathogen Moraxella catarrhalis IgD-binding protein MID.

The Moraxella catarrhalis IgD-binding protein (MID) has a unique specificity for human IgD, and the sequence with maximal IgD binding is located within the amino acids MID962-1200. In the present paper, we examined the MID binding site on IgD using a series of recombinant Ig. Full-length IgD, IgD F(ab')(2), and an IgD F(ab') C290R mutant lacking the inter-heavy-chain cysteine 290 were manufactured

Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study

Purpose Human papillomavirus (HPV) has been linked to oropharyngeal carcinomas, but its role in laryngeal squamous cell carcinoma (LSCC) is not clear. A prospective multicenter study based on known tumor-cell percentage of fresh frozen carcinoma biopsies was established to determine the HPV prevalence. Moreover risk factors such as smoking, alcohol abuse, chronic laryngitis and gastroesophageal re

A tool to model short crack fatigue growth using a discrete dislocation formulation

A method is presented that combines the modelling of cracks by distributed dislocation dipoles with developing plasticity represented by discrete dislocations moving along slip bands. Crack growth is due to the emission of dislocations from the crack tip along preferred slip planes. Eventual annihilation of dislocations occurs by reunion with the corresponding displacement steps of the crack surfa

Effects of Metal-Binding Loop Mutations on Ligand Binding to Calcium- and Integrin-Binding Protein 1. Evolution of the EF-Hand?

Calcium- and integrin-binding protein 1 (CIB1) is a ubiquitous, multifunctional regulatory protein consisting of four helix-loop-helix EF-hand motifs. Neither EF-I nor EF-II binds divalent metal ions; however, EF-III is a mixed Mg2+/Ca2+-binding site, and EF-IV is a higher-affinity Ca2+-specific site. Through the generation of several CIB1 mutant proteins, we have investigated the importance of th

Evidence for the Active Phase of Heterogeneous Catalysts through In Situ Reaction Product Imaging and Multiscale Modeling

We use multiscale modeling to analyze laser-induced fluorescence (LIP) measurements of the CO oxidation reaction over Pd(100) at near-ambient reaction conditions. Integrating density functional theory-based kinetic Monte Carlo simulations of the active catalyst into fluid-dynamical simulations of the mass transport inside the reactor chamber, we calculate the reaction product concentration directl

A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates

The development of models that provide accurate spatio-temporal predictions of ambient air pollution at small spatial scales is of great importance for the assessment of potential health effects of air pollution. Here we present a spatio-temporal framework that predicts ambient air pollution by combining data from several different monitoring networks and deterministic air pollution model(s) with

Effects of Mobile Phone Radiation upon the Mammalian Brain

oday about half of the world's population owns the microwave producing mobile phones. The blood-brain barrier (BBB) protects the mammalian brain from potentially harmful substances circulating in the blood. The permeability of the BBB has been shown to be increased after exposure to electromagnetic fields (EMFs) of the kind emitted by mobile phones and neuronal damage has been found several weeks

Welfare calculations in models of the demand for sanitation

Empirical and theoretical research on the demand for health inputs has been, and still is, extensive. However, it is not only important to analyse how household choice is affected by alternative and household specific attributes. but it is equally important to analyse the welfare implications of, for example, a change in the price of different inputs. Policyrnakers and donor agencies involved in s

Aire-ing self antigen variability and tolerance.

Positional cloning of the underlying genes for the rare syndrome autoimmune polyendocrinopathy candidadiasis extrodermal dystrophy (APECED) opened a new venue of research on the role of central tolerance in autoimmunity. The associated autoimmune regulator gene (AIRE), was found to be expressed in medullary thymus epithelial cells (mTEC) in both man and mice, and to control promiscuous expression

Endothelin-1 Reduces Microvascular Fluid Permeability through Secondary Release of Prostacyclin in Cat Skeletal Muscle.

The aim of the study was to analyze effects of various plasma concentrations of the vasoconstrictor endothelin-1 on microvascular fluid permeability and on transcapillary fluid exchange. We also analyzed whether the permeability-reducing substance prostacyclin is involved in the permeability effects of endothelin-1, as prostacylin is suggested to be released via ET(B) receptor stimulation. The stu

Experimental design of multifactor climate change experiments with elevated CO2, warming and drought: the CLIMAITE project

Recent findings indicate that the interactions among CO2, temperature and water can be substantial, and that the combined effects on the biological systems of several factors may not be predicted from experiments with one or a few factors. Therefore realistic multifactorial experiments involving a larger set of main factors are needed. We describe a new Danish climate change-related field scale ex