Hematopoietic stem cells (HSCs) are maintained in hypoxic niches in endosteal regions of bones. Here we demonstrate that Cripto and its receptor GRP78 are important regulators of HSCs in the niche. Flow cytometry analyses revealed two distinct subpopulations of CD34(-)KSL cells based on the expression of GRP78, and these populations showed different reconstitution potential in transplantation assa

Macromolecular drugs hold great promise as novel therapeutics of several major disorders, such as cancer and cardiovascular disease. However, their use is limited by lack of efficient, safe, and specific delivery strategies. Successful development of such strategies requires interdisciplinary collaborations involving researchers with expertise on, e.g., polymer chemistry, cell biology, nanotechnol

Low aerobic fitness (maximum oxygen uptake (VO(2PEAK))) is predictive for poor health in adults. In a cross-sectional study, we assessed if VO(2PEAK) is related to a composite risk factor score for cardiovascular disease (CVD) in 243 children (136 boys and 107 girls) aged 8 to 11 years. VO(2PEAK) was assessed by indirect calorimetry during a maximal exercise test and scaled by body mass (millilite

Essay over the life and letters of Swedish artist and filmmaker Eivor Burbeck (1926 - 1965), a modernist forerunner within poetry as well as experimental film, and one of the few active female members of the Stockholm Independent Film Group during the 1950s. The article includes a complete bibliography over her own works.

BACKGROUND: Spousal caregivers of cancer patients suffer psychological and physical burdens, which may affect their risk of subsequently developing coronary heart disease (CHD) and stroke. METHODS AND RESULTS: Cancer patients were identified in the Swedish Cancer Registry, and information on their spouses was retrieved from the Swedish Multi-Generation Register. Follow-up of caregivers was carri

Conditionally replicative adenovirus (CRAD) represents a promising approach for cancer therapy. Several CRADs controlled by the human telomerase reverse transcriptase promoter have been developed. However, because of their replicative capacity, the importance of cancer specificity for CRADs needs to be further emphasized. In this study, we have developed a novel dual-regulated CRAD, CNHK500-mE, wh

Context: Dopamine agonists are the treatment of choice for prolactinomas and symptomatic idiopathic hyperprolactinemia. However, the optimal treatment strategy and treatment duration is not clear in all details. Objective: The aim of the study was to assess the effect of dopamine agonist withdrawal in patients with idiopathic hyperprolactinemia and prolactinomas. Data Sources: PubMed, the Cochrane

Popular Abstract in Swedish Många människor tillbringar en stor del av dygnet på en arbetsplats, vilket innebär att det är en plats och en tid inte bara för arbete utan också för sociala relationer samt för mat och dryck. Maten, vare sig det handlar om lunchen klockan tolv, eftermiddagsfikan klockan tre eller chokladbiten under nattskiftet, bidrar till att skapa pauser i arbetet. Arbetsplatsen kanMany people spend hours in a workplace every week and food and drink play a central role in providing nutrition and energy and help to create breaks during the working day. However, meals are something more than the food consumed. This dissertation focuses on the meal at work, where the meal is surrounded by special circumstances when it comes to time, place and social relations, as well as the fo

Abstract OBJECTIVES: To investigate the effects of antenatal betamethasone on fetal and uteroplacental hemodynamics. METHODS: The study comprised 33 women with singleton high-risk pregnancies (23-33 weeks; 27 pregnancies < 30 weeks) not in labor, but at risk for preterm delivery based on fetal or maternal indications. They were treated with two doses of 12 mg betamethasone intramuscularly 24 h ap

Review of the English translation of the novel Die Ästhetik des Widerstands by German-Swedish writer Peter Weiss (1916 - 1982) in connection with the problems of the avant-garde as critical practice (the overall theme of this issue of the journal Reconstruction which is concluded by the review in question).

The article explores issues concerning the reconfiguration of human and animal bodies in modern biotechnology. The examples are based on xenotransplantation: Transplantation of cells, tissue and organs from animals to humans. Three thematic issues that emerged from xenotransplantation research in Sweden in the 1990s and early 2000s are examined in the article. The first issue concerns how the pig