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Location of metastases in cancer of unknown primary are not random and signal familial clustering.

Cancer of unknown primary (CUP) is a fatal disease diagnosed through metastases. It shows intriguing familial clustering with certain defined primary cancers. Here we examine whether metastatic location in CUP patients is related to primary non-CUP cancers in relatives based on the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP patients defined by metastatic

Robust Multichannel Detection of Mixtures Using Nuclear Quadrupole Resonance'

Nuclear quadrupole resonance (NQR) is a radio-frequency (RF) spectroscopic technique, able to detect the presence of many high explosives and narcotics. In practice, the weak NQR signal is often corrupted by strong RF interference (RFI); therefore, various multichannel detection algorithms have recently been proposed for NQR. However, these algorithms allow for only a single compound/polymorph, wh

Biomarkers of early chronic obstructive pulmonary disease (COPD) in smokers and former smokers. Protocol of a longitudinal study.

Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD: in fact, most develop some amount of pulmonary impairment. Smoking-related COPD is associated with both acute exacerbations and is closely correlated to comorbidities, such as cardiovascula

Tactile sensitivity of gloved hands in the cold operation

In this study, tactile sensitivity of gloved hand in the cold operation has been investigated. The relations among physical properties of protective gloves and hand tactile sensitivity and cold protection were also analysed both objectively and subjectively. Subjects with various gloves participated in the experimental study during cold exposure at different ambient temperatures of -12°C and -25°C

A simple directional path loss model for a terminal inside a car

Measurements of the radiation from a dipole lambda/2-dipole antenna inside a common car was compared to calculations at 1.9 GHz, to establish a principal knowledge of the radiation mechanism related to a vehicle such as a car. Based on this a new simple directional path loss model is proposed, that uses minimal knowledge of the vehicle's geometry. This model may be well suited for simulations of m

Menisk- och korsbandsskador

The treatment of meniscus tears and anterior cruciate ligament (ACL) injuries are mainly considered as symptomatic. Meniscus tears can be divided into traumatic and degenerative tears, with different outcomes. A displaced meniscus with a locked knee constitutes an acute indication for arthroscopic surgery. A degenerative tear with mechanical symptoms also represents an indication for surgery. The

Genetic Diversity and Population Structure in a Legacy Collection of Spring Barley Landraces Adapted to a Wide Range of Climates

Global environmental change and increasing human population emphasize the urgent need for higher yielding and better adapted crop plants. One strategy to achieve this aim is to exploit the wealth of so called landraces of crop species, representing diverse traditional domesticated populations of locally adapted genotypes. In this study, we investigated a comprehensive set of 1485 spring barley lan