Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment. These features define a subset of cancer with a favorable prognosis and high likelihood to respond to treatment with anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) drugs. With the aim to define imm

Existing event detection algorithms for eye-movement data almost exclusively rely on thresholding one or more hand-crafted signal features, each computed from the stream of raw gaze data. Moreover, this thresholding is largely left for the end user. Here we present and develop gazeNet, a new framework for creating event detectors that do not require hand-crafted signal features or signal threshold

Paying privately for childcare is a growing phenomenon, and its rise in Sweden is particularly interesting because of the vast prevalence there of publicly funded day care. This book combines family practice and childhood studies theory with the personal perspectives of nannies and au pairs, parents, and the children themselves, to provide new understandings of what constitutes ‘good care’. The auPaying privately for childcare is a growing phenomenon, and its rise in Sweden is particularly interesting because of the vast prevalence there of publicly funded day care. This book combines family practice and childhood studies theory with the personal perspectives of nannies and au pairs, parents, and the children themselves, to provide new understandings of what constitutes ‘good care’. The au

Political initiatives such as tax deductions for domestic services, including nannies, has, together with a growing au pair market paved the way for new possibilities of organizing child care in Sweden. This affects the everyday ‘local care loops’ for the upper middle-class families purchasing the services; the logistics of solving the work/family dilemma is changed through the possibility of hiri

Delegated, but still intensive: Quality time and parenting in upper-middle class families in Sweden During the last decade, Swedish families have started to employ nannies and au pairs to an extent previously never experienced. Political initiatives such as tax deductions for household services, together with global trends of ‘care chains’, have created a private market for care services, which ha

A new actor has been (re)introduced into family practices in Sweden: the nanny. Previous ways of organizing care for children (mainly through publicly funded daycare) are today being complemented by a growing private market for childcare, often performed by migrant women. In our research project Care for children in an era of private market service we study the practice of doing care and family in

Children’s biographies are only rarely and more recently considered. In this paper, we make a case for thinking biographically about children’s relational lives. Using two qualitative case studies from research with children in middle childhood, in the UK and Sweden, we attend to the materiality of children’s biographies. We explore the way in which home spaces, possessions, family mementoes and mChildren’s biographies are only rarely and more recently considered. In this paper, we make a case for thinking biographically about children’s relational lives. Using two qualitative case studies from research with children in middle childhood, in the UK and Sweden, we attend to the materiality of children’s biographies. We explore the way in which home spaces, possessions, family mementoes and m

A new actor has been (re)introduced into family practices in Sweden: the nanny. Previous ways of organizing care for children (mainly through publicly funded daycare) are today being complemented by a growing private market for childcare, often performed by migrant women. In our research project Care for children in an era of private market service we study the practice of doing care and family in

Introduction: A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete-scute family bHLH transcription factor 1 (ASCL1), common to high-grade neuroendocrine tumors, small-cell lung cancer and large cell neuroendocrine carcinoma. Methods: The aim of this study was to characterize clinical and molecular features of ASCL1-positive lung adenocarcinoma by using r

Background: Reproducible quantification of drug transporter protein expression in tissues is important for predicting transporter mediated drug disposition. Many mass-spectrometry based transporter protein quantification methods result in high variability of the estimated transporter quantities. Therefore, we aimed to evaluate and optimize mass spectrometry-based quantification method for drug tra

This work reports on numerical investigation of effects of ambient pressure (Pam) on spray combustion under engine-like conditions. Three cases with different Pam of 42, 85 and 170 bar at a fixed ambient temperature of 1000 K are considered. Zero-dimensional calculations are first performed for autoignition of stagnant adiabatic homogenous mixtures to evaluate performance of the selected diesel su

This chapter examines the human search, understanding, and interpretation of biosignatures. It deals with four epistemological issues in the search for signs of life in outer space: (1) conceptualization, how we form concepts of life in astrobiology, how we define and categorize things, and the relation between our concepts and our knowledge of the world; (2) analogy, how we see similarities betwe

Phosphoinositide (PIP) lipids are anionic phospholipids playing a fundamental role for the activity of several transmembrane and soluble proteins. Among all, phosphoinositol-3′,4′,5′-trisphosphate (PIP3) is a secondary signaling messenger that regulates the function of proteins involved in cell growth and gene transcription. The present study aims to reveal the structure of PIP-containing lipid me

Enhancing a combustion system requires increased combustion efficiency, fuel savings, and reduction of combustion emissions. In this paper, the combustion of CH4 in the combustor of an industrial gas turbine is studied and NO and CO formation/emission is simulated numerically. The objective of the current work is to investigate the influence of combustive parameters and varying the percentage of d

The EU's farmers are no longer required to produce commodities to receive direct payments as long as they keep their land in good condition. Some believe this is bad for development because it encourages passive farming. We evaluate, using a real options approach, the implications of decoupled payments for the desirability and optimal timing of agricultural land development when considering sunk i

The evolution of Software-Defined Networking (SDN) has so far been predominantly geared towards defining and refining the abstractions on the forwarding and control planes. However, despite a maturing south-bound interface and a range of proposed network operating systems, the network management application layer is yet to be specified and standardized. It has currently poorly defined access contr