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Respiratory Modulation in Permanent Atrial Fibrillation

Several studies have shown that the autonomic nervous system (ANS) can induce changes during atrial fibrillation (AF). There is currently a lack of methods for quantifying ANS induced variations during AF. The purpose of this study is to quantify respiratory induced modulation in the f-wave frequency trend. Following qrst-cancellation, the local f-wave frequency is estimated by fitting a harmonic

Model-Based Characterization of Atrial Fibrillation Episodes and its Clinical Association

Studies investigating risk factors associated with atrial fibrillation (AF) have mostly focused on AF presence and burden, disregarding the temporal distribution of AF episodes although such information can be relevant. In the present study, the alternating, bivariate Hawkes model was used to characterize paroxysmal AF episode patterns. Two parameters: the intensity ratio µ, describing the dominat

Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation : A Computational and Experimental Study

The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded fro

Investigating Respiratory Rate Estimation during Paroxysmal Atrial Fibrillation Using an Improved ECG Simulation Model

The present study addresses the problem of respiratory rate estimation from ECG-derived respiration (EDR) signals during paroxysmal atrial fibrillation (AF). Novel signal-to-noise ratios between various components of the ECG including the influence of respiration, measured by QRS ensemble variance, the amplitude of fibrillatory waves (f-waves), and the QRS amplitude are introduced to characterize

Natural and flexible error recovery for generated parsers

Parser generators are an indispensable tool for rapid language devel- opment. However, they often fall short of the finesse of a hand-crafted parser, built with the language semantics in mind. One area where generated parsers have pro- vided unsatisfactory results is that of error recovery. Good error recovery is both natural, giving recovery suggestions in line with the intention of the programme

Validation of the modified Skåne emergency department assessment of patient load (mSEAL) model for emergency department crowding and comparison with international models; an observational study

Background: Emergency Department crowding is associated with increased morbidity and mortality but no measure of crowding has been validated in Sweden. We have previously derived and internally validated the Skåne Emergency Department Assessment of Patient Load (SEAL) score as a measure of crowding in Emergency Departments (ED) in a large regional healthcare system in Sweden. Due to differences in

A just transition towards a coal-free steel industry: perspectives from labour

Limiting global warming to ‘safe’ levels will require rapid and radical reductions of greenhouse gas emissions across all sectors of the global economy. The discontinuation of incumbent industrial structures, that will be an unavoidable part of such sustainability transitions, will disproportionally burden certain groups. Recent events including the social and political unrest linked to the immine

Relationship between insulin sensitivity and gene expression in human skeletal muscle

BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly understood.METHODS: To explore these mechanisms, we related global skeletal muscle gene expression profiling of 38 non-diabetic men to a surrogate measu

The role of environmental requirements in Swedish public procurement of bus transports

The transport sector needs to become sustainable and public transport has an important role to play. Green public procurement has proven to have great potential to influence the transition to a sustainable public transport sector. Sweden is a good example of a country that uses public procurement in the public transport sector to a large extent and has at the same time come far in the transition t

Medical crisis checklists in the emergency department : a simulation-based multi-institutional randomised controlled trial

Background: Studies carried out in simulated environments suggest that checklists improve the management of surgical and intensive care crises. Whether checklists improve the management of medical crises simulated in actual emergency departments (EDs) is unknown. Methods: Eight crises (anaphylactic shock, life-threatening asthma exacerbation, haemorrhagic shock from upper gastrointestinal bleeding

Two screening instruments for collecting alcohol-related information from expectant mothers and fathers : Testing the reliability of the Parent Alcohol Screening Questionnaire and the Social Support for an Alcohol-Free Pregnancy Questionnaire

The aim is to test the reliability of two alcohol screening instruments: (1) The Parent Alcohol Screening Questionnaire (PASQ5), and (2) the Social Support for an Alcohol-free Pregnancy (SSAFP) questionnaire. This is a cohort study from the south of Sweden using repeated surveys during pregnancy. To examine if responses differed according to different data collection methods, two cohorts consistin

Endovascular Relining of Chronically Occluded Infrainguinal Venous Bypass Grafts

Background: Treatment of chronically occluded infrainguinal venous bypass grafts in patients presenting with recurrent chronic limb threatening limb ischemia (CLTI) represent a clinical challenge. Recent case reports have suggested the use of endovascular recanalization techniques without preceding thrombolysis. This study assesses feasibility and mid-term outcomes of this technique. Results: A re

Implementation of National Guidelines increased survival in advanced ovarian cancer - A population-based nationwide SweGCG study

Aim: The first Swedish National Guidelines for Ovarian Cancer (NGOC) were published in 2012. We aimed to evaluate surgical outcomes and survival in patients with stage IIIC-IV disease, before and after the NGOC implementation. Method: Women with primary epithelial ovarian cancer, FIGO stage IIIC–IV, registered in the Swedish Quality Registry for Gynecologic Cancer 2008–2011 and 2013–2016 were incl

Evaluation of 92 cardiovascular proteins in dried blood spots collected under field-conditions : Off-the-shelf affinity-based multiplexed assays work well, allowing for simplified sample collection

Workplace-collected blood spots deposited on filter paper were analysed with multiplexed affinity-based protein assays and found to be suitable for proteomics analysis. The protein extension assay (PEA) was used to characterize 92 proteins using 1.2 mm punches in repeated samples collected from 20 workers. Overall, 97.8% of the samples and 91.3% of the analysed proteins passed quality control. Bot

Cerebral autoregulation in infants during sevoflurane anesthesia for craniofacial surgery

Background: Data on cerebral pressure-flow autoregulation in the youngest children are scarce. We studied the correlation between mean arterial pressure and cerebral tissue oxygen saturation (rSO2) by near-infrared spectroscopy (NIRS) in patients undergoing nose, lip, and palate surgery. Aim: We tested the hypothesis that cerebral pressure-flow autoregulation is impaired in children less than 1 ye

Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis

Tick-borne encephalitis (TBE) is a widespread viral infection of the central nervous system with increasing incidence in Europe and northern Asia. Post-infectious sequelae are frequent, and patients with TBE commonly experience long-term fatigue and subjective sleep disturbances. Obstructive sleep apnea (OSA) may be a contributing factor, and objective sleep studies with polysomnography (PSG) are

Relaying techniques for enhancing the physical layer secrecy in cooperative networks with multiple eavesdroppers

Physical layer security has recently attracted considerable attention in the context of information-theoretic point of view. In this paper, we investigate relay selection schemes for security-constrained half-duplex cooperative wireless networks with multiple eavesdroppers, which have the ability to cooperate to overhear the source transmission. The proposed techniques select a trusted decode-and-