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RIFM fragrance ingredient safety assessment, 2-ethyl-1,3,3-trimethyl-2-norbornanol, CAS Registry Number 18368-91-7
False Alarm Reduction in Atrial Fibrillation Screening
Early detection of AF is essential and emphasizes the significance of AF screening. However, AF detection in screening ECGs, usually recorded by handheld and portable devices, is limited because of their high susceptibility to noise. In this study, the feasibility of applying a machine learning-based quality control stage, inserted between the QRS detector and AF detector blocks, is investigated w
Continuous close-range 3D object pose estimation
In the context of future manufacturing lines, removing fixtures will be a fundamental step to increase the flexibility of autonomous systems in assembly and logistic operations. Vision-based 3D pose estimation is a necessity to accurately handle objects that might not be placed at fixed positions during the robot task execution. Industrial tasks bring multiple challenges for the robust pose estima
RIFM low-exposure fragrance ingredients safety assessment
The existing information supports the use of these materials as described in this safety assessment. The 167 materials identified in this assessment were evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Target data, read-across analogs and TTC show that these materi
Liproca Depot : A New Antiandrogen Treatment for Active Surveillance Patients
Background: There is increasing interest in nonmorbid treatments for low- and intermediate-risk prostate cancer with fewer side effects than surgery or radiotherapy. Objective: To investigate the tolerability, safety, and antitumor effects of the intraprostatic NanoZolid depot formulation Liproca Depot (LIDDS AB, Uppsala, Sweden) with antiandrogen 2-hydroxyflutamide (2-HOF) in men with low- or int
Wintering bird communities are tracking climate change faster than breeding communities
Global climate change is driving species' distributions towards the poles and mountain tops during both non-breeding and breeding seasons, leading to changes in the composition of natural communities. However, the degree of season differences in climate-driven community shifts has not been thoroughly investigated at large spatial scales. We compared the rates of change in the community composition
Sintering of Superhard cBN-Based Materials with Ti4WC5
Abstract: The physicomechanical properties and structure of superhard cBN–Ti4WC5–Al materials were studied. The materials were sintered under a pressure of 7.7 GPa within a broad range of temperatures (1600–2450°C). The formation of a dense material with high physicomechanical properties was found at a sintetring temperature of 1800°C. A further increase in the sintering temperature had a negligib
Respiratory Modulation in Permanent Atrial Fibrillation
Several studies have shown that the autonomic nervous system (ANS) can induce changes during atrial fibrillation (AF). There is currently a lack of methods for quantifying ANS induced variations during AF. The purpose of this study is to quantify respiratory induced modulation in the f-wave frequency trend. Following qrst-cancellation, the local f-wave frequency is estimated by fitting a harmonic
Model-Based Characterization of Atrial Fibrillation Episodes and its Clinical Association
Studies investigating risk factors associated with atrial fibrillation (AF) have mostly focused on AF presence and burden, disregarding the temporal distribution of AF episodes although such information can be relevant. In the present study, the alternating, bivariate Hawkes model was used to characterize paroxysmal AF episode patterns. Two parameters: the intensity ratio µ, describing the dominat
Response to Olga Bertelsen's Article
Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation : A Computational and Experimental Study
The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded fro
Investigating Respiratory Rate Estimation during Paroxysmal Atrial Fibrillation Using an Improved ECG Simulation Model
The present study addresses the problem of respiratory rate estimation from ECG-derived respiration (EDR) signals during paroxysmal atrial fibrillation (AF). Novel signal-to-noise ratios between various components of the ECG including the influence of respiration, measured by QRS ensemble variance, the amplitude of fibrillatory waves (f-waves), and the QRS amplitude are introduced to characterize
Natural and flexible error recovery for generated parsers
Parser generators are an indispensable tool for rapid language devel- opment. However, they often fall short of the finesse of a hand-crafted parser, built with the language semantics in mind. One area where generated parsers have pro- vided unsatisfactory results is that of error recovery. Good error recovery is both natural, giving recovery suggestions in line with the intention of the programme
Validation of the modified Skåne emergency department assessment of patient load (mSEAL) model for emergency department crowding and comparison with international models; an observational study
Background: Emergency Department crowding is associated with increased morbidity and mortality but no measure of crowding has been validated in Sweden. We have previously derived and internally validated the Skåne Emergency Department Assessment of Patient Load (SEAL) score as a measure of crowding in Emergency Departments (ED) in a large regional healthcare system in Sweden. Due to differences in
A just transition towards a coal-free steel industry: perspectives from labour
Limiting global warming to ‘safe’ levels will require rapid and radical reductions of greenhouse gas emissions across all sectors of the global economy. The discontinuation of incumbent industrial structures, that will be an unavoidable part of such sustainability transitions, will disproportionally burden certain groups. Recent events including the social and political unrest linked to the immine
Relationship between insulin sensitivity and gene expression in human skeletal muscle
BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly understood.METHODS: To explore these mechanisms, we related global skeletal muscle gene expression profiling of 38 non-diabetic men to a surrogate measu
The role of environmental requirements in Swedish public procurement of bus transports
The transport sector needs to become sustainable and public transport has an important role to play. Green public procurement has proven to have great potential to influence the transition to a sustainable public transport sector. Sweden is a good example of a country that uses public procurement in the public transport sector to a large extent and has at the same time come far in the transition t
Imaging aspects of mild cognitive impairment and subjective cognitive decline. Application of visual rating scales in clinical practice.
Medical crisis checklists in the emergency department : a simulation-based multi-institutional randomised controlled trial
Background: Studies carried out in simulated environments suggest that checklists improve the management of surgical and intensive care crises. Whether checklists improve the management of medical crises simulated in actual emergency departments (EDs) is unknown. Methods: Eight crises (anaphylactic shock, life-threatening asthma exacerbation, haemorrhagic shock from upper gastrointestinal bleeding