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Arabidopsis thaliana NUDT1 (AtNUDT1) belongs to the Nudix family of proteins, which have a diverse range of substrates, including oxidized nucleotides such as 8-oxo-dGTP. The hydrolysis of oxidized dNTPs is highly important as it prevents their incorporation into DNA, thus preventing mutations and DNA damage. AtNUDT1 is the sole Nudix enzyme from A. thaliana shown to have activity against 8-oxo-dG

Background: Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response to treatment in different subgroups and obstruct clinical trials. Our aim was to understand how SLE subgroups may differ regarding underlying pathophysiology and characteristic b

In temperate environments, ring width, cell size and cell wall thickness within the xylem of trees are known to be affected by climate conditions. Less is known about the effect of climate conditions on the chemical characteristics of the xylem, which are important for the susceptibility of the tissue towards fungal infections as well as for the degradability of the material within the forest ecos

The first measurement of dielectron (e+e-) production in central (0-10%) Pb-Pb collisions at sNN=2.76TeV at the LHC is presented. The dielectron invariant-mass spectrum is compared to the expected contributions from hadron decays in the invariant-mass range 0

We report on the first femtoscopic measurement of baryon pairs, such as p-p, p-Λ, and Λ-Λ, measured by ALICE at the Large Hadron Collider (LHC) in proton-proton collisions at s=7TeV. This study demonstrates the feasibility of such measurements in pp collisions at ultrarelativistic energies. The femtoscopy method is employed to constrain the hyperon-nucleon and hyperon-hyperon interactions, which a

We use the societal exergy analysis to identify periods and factors controlling efficiency dilution and carbon deepening of electricity in Portugal from 1900 to 2014. Besides estimating the carbon intensity of electricity production, we propose a new indicator, the carbon intensity of electricity use, which quantifies CO 2 /kWh of electricity derived useful exergy. Results show final to useful e

Background Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning

Attribution has become a recurring issue in discussions about Loss and Damage (L&D). In this highly-politicised context, attribution is often associated with responsibility and blame; and linked to debates about liability and compensation. The aim of attribution science, however, is not to establish responsibility, but to further scientific understanding of causal links between elements of the

The debate on “Loss and Damage” (L&D) has gained traction over the last few years. Supported by growing scientific evidence of anthropogenic climate change amplifying frequency, intensity and duration of climate-related hazards as well as observed increases in climate-related impacts and risks in many regions, the “Warsaw International Mechanism for Loss and Damage” was established in 2013 and

Our current global food system – from food production to consumption, including manufacture, packaging, transport, retail and associated businesses – is responsible for extensive negative social and environmental impacts which threaten the long-term well-being of society. This has led to increasing calls from science–policy organizations for major reform and transformation of the global food syste

The time scale of the dynamics in atoms and molecules varies from attoseconds (10-18) to picoseconds (10-12) depending on the size of the particles. To study such dynamics, ultrafast light pulses are needed to trigger and capture the reaction. One of the most direct methods consists in ionizing the system and observing the following response. In this work, we use two different light sources with c

Följande rapport redovisar en studie inom forskningsprojektet Bostadsbränder i stor-stadsområden - rumsliga skillnader och brandsäkerhetsarbete i den socialt fragmenterade staden. Syftet med rapporten är att analysera i vad mån skillnaderna i statistiken gällande bostadsbränder i storstadsområdena Malmö, Göteborg, Södertörn och Stockholm kan förklaras av olikheter i hur inrapporteringen av bostads

Syftet med denna rapport är att ge en teoretisk ram kring hur bostadsbränder kan förstås och analyseras. I kommande rapporter kommer mer utvecklade jämförelser och statistiska analyser att presenteras.