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High levels of vitamin D associated with less ischemic heart disease – A nested case-control study among rural men in Sweden

Introduction and objective. Low levels of serum vitamin D have been associated with increased occurrence of ischemic heart disease (IHD), but findings are inconsistent, e.g. seasonal variation is not always considered in the analyses. The aim of this study was to investigate whether vitamin D is associated with IHD among rural middle-aged men in Sweden when seasonal variation is taken into account

Attachment styles of dermatological patients in europe : A multicentre study in 13 countries

Attachment styles of dermatological outpatients and satisfaction with their dermatologists were investigated within the framework of a multicentre study conducted in 13 European countries, organized by the European Society for Dermatology and Psychiatry. Attachment style was assessed with the Adult Attachment Scale. Patient satisfaction with the dermatologist was assessed with an 11-degree scale.

Integrating Flood Risk, River Basin Management and Adaptive Management : Gaps, Barriers and Opportunities, Illustrated by a Case Study from Kristianstad, Sweden

The increasing risk of floods in Europe calls for a revision of current governance and management practices. Sweden has not yet experienced flood events of the magnitude seen in central Europe over the past few years; hence flood-risk management is low on its political agenda. This paper investigates the gaps, barriers and opportunities in implementation of flood risk reduction, which to be effect

Validating the existence of the supercraton Vaalbara in the Mesoarchaean to Palaeoproterozoic

Det är allmänt känt att kontinenter under Jordens historia har separerat och kolliderat i ett cykliskt förlopp vilket har lett till existensen av större landmassor, superkontinenter eller superkratoner under vissa tidsperioder. En av de tidigaste föreslagna superkratonerna är Vaalbara, som sedan 1960-talet har ansetts bestå av Kaapvaalkratonen i södra Afrika och Pilbarakratonen i västra AustralienIn this thesis, the longevity and continuity of the Vaalbara supercraton is addressed in six papers aimed at placing new temporal and spatial constraints onthe supercraton in the Mesoarchean to Paleoproterozoic. It has been speculated since the 1960’s that the Kaapvaal Craton in southern Africa, together withthe Pilbara Craton in Western Australia existed as a single landmass during the Precambria

A case-matched gender comparison transcriptomic screen identifies eIF4E and eIF5 as potential prognostic markers in male breast cancer

Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assumptions that underlying biology is similar. Experimental Design: A transcriptomic investigation of male and female breast cancer was performed, confirming transc

Modeling the absorption spectrum of the permanganate ion in vacuum and in aqueous solution

The absorption spectrum of the MnO4 - ion has been a test-bed for quantum-chemical methods over the last decades. Its correct description requires highly-correlated multiconfigurational methods, which are incompatible with the inclusion of finite-temperature and solvent effects due to their high computational demands. Therefore, implicit solvent models are usually employed. Here we show that impli

Analysis of hypo- and hyperphosphatemia in an intensive care unit cohort

BACKGROUND: Blood phosphate levels are vulnerable to fluctuations and changes in phosphate levels are often neglected. The aim of this study was to evaluate whether deviations in phosphate levels correlate to higher 180-day overall mortality or morbidity. METHODS: Four thousand six hundred fifty-six patients with 19,467 phosphate values treated at the adult intensive care unit at Skåne University

Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease

The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and reg

The association of mobility disability and weight status with risk of disability pension : A prospective cohort study

BACKGROUND/AIMS: Mobility disability (MD) and obesity are conditions which have been associated with weaker labour market attachment. This study investigates whether the combined burden of MD and obesity increase the risk of disability pension compared with having only one of these conditions (the reference group).METHODS: A nationwide cohort study, based on national surveys made between 1996 and

Advocacy Coalition Learning – Biases and Heuristics in Policy Implementation

Policy implementation is a complex process and the theoretical problem has been approached in different ways for a long time. Perspectives have converged around governance, negotiation and adaptation and the learning perspective is increasingly acknowledged. This paper explores how policy implementation may be understood from a learning perspective, affected by universal tendencies for humans to d

The density of parasympathetic axons is reduced in the exocrine pancreas of individuals recently diagnosed with type 1 diabetes

To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Huma

Posttraumatic bone marrow lesion volume and knee pain within 4 weeks after anterior cruciate ligament injury

Context: After an anterior cruciate ligament (ACL) injury, a majority of patients have a traumatic bone marrow lesion (BML, or bone bruise). The clinical relevance of posttraumatic lesions remains unclear. Objective: To explore the cross-sectional associations between traumatic BML volume and self-reported knee pain and symptoms among individuals within 4 weeks of ACL injury. Design: Cross-section

Design and performance prediction of timber bridges based on a factorization approach

Service life of timber bridges is predominantly affected by the site-specific climatic conditions in terms of moisture and temperature over time, the overall design, the design of details, and the choice of materials. In recent years, a performance-based methodology has been developed to predict (1) the material climatic conditions within timber components from macro climate data and comparison be

Influence of the helicopter configuration on its electrostatic charging

A helicopter flying through an atmosphere containing particulates may accumulate high electrostatic charges which can challenge its operational safety. In this paper we report on the in uence of the helicopter configuration on its electrification. Our study is based on a recently developed numerical approach according to which the turbulent air flow around the rotorcraft is estimated via large edd

Long-term safety of once-daily, dual-release hydrocortisone in patients with adrenal insufficiency : a phase 3b, open-label, extension study

OBJECTIVE: To investigate the long-term safety and tolerability of a once-daily, dual-release hydrocortisone (DR-HC) tablet as oral glucocorticoid replacement therapy in patients with primary adrenal insufficiency (AI).DESIGN: Prospective, open-label, multicenter, 5-year extension study of DR-HC conducted at five university clinics in Sweden.METHODS: Seventy-one adult patients diagnosed with prima