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Long-term Safety and Efficacy of Reslizumab in Patients with Eosinophilic Asthma

Background In placebo-controlled trials, reslizumab, an anti-IL-5 monoclonal antibody, significantly reduced asthma exacerbations and improved lung function and asthma control in patients with eosinophilic asthma. Objective This open-label extension study evaluated safety and efficacy of reslizumab for up to 24 months. Methods After participation in 1 of 3 placebo-controlled, phase III trials in m

Reduced order modelling of elastomeric vibration isolators in dynamic substructuring

Dynamic substructuring is often employed to reduce the size of numerical models for structural dynamic analysis. In this paper, we discuss how elastomeric vibration isolators can be modelled within the framework of dynamic substructuring in order to obtain accurate and efficient reduced order models. For several reasons, it is beneficial to divide a structure containing elastomeric isolators into

Thinking fast, thinking badly

We test for the construct validity of the cognitive reflection test (CRT) by eliciting response times. We find that incorrect answers to the CRT are quicker than correct answers. At the individual level, we classify subjects into impulsive and reflective, depending on whether they choose the incorrect intuitive answer or the correct answer the majority of the time. We show that impulsive subjects

Influence of the number of injections on piston heat rejection under low temperature combustion conditions in an optical compression-ignition engine

New combustion concepts are being investigated to develop cleaner engines. One of the most promising is partially premixed combustion. The mechanisms of this combustion mode and its impact on performance and emissions have been studied in the previous years. Nevertheless, little research has been done from the point of view of heat transfer. In particular, the influence of the injection strategy o

Micro-focusing of broadband high-order harmonic radiation by a double toroidal mirror

We present an optical system based on two toroidal mirrors in aWolter configuration to focus broadband extreme ultraviolet (XUV) radiation. Optimization of the focusing optics alignment is carried out with the aid of an XUV wavefront sensor. Back-propagation of the optimized wavefront to the focus yields a focal spot of 3.6 × 4.0 μm2 full width at half maximum, which is consistent with ray-tracing

Balancing authority and autonomy in higher education by implementing an agile project management approach

This article develops and implements an agile management approach in higher education. Such an approach follows core practices, such as project plans. The project manager has to identify the agility drivers that represent changes and pressures; prioritize agility capabilities to take advantage of changes; identify agility providers to obtain agility capabilities; and make managerial choices to man