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This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory.
Background and purpose: Treatment plan evaluation is a clinical decision-making problem that involves visual search and analysis in a contextually rich environment, including delineated structures and isodose lines superposed on CT data. It is a two-step process that includes visual analysis and clinical reasoning. In this work, we used eye tracking methods to gain more knowledge about the treatme
Purpose: The Oriatron eRT6 is an experimental high dose-per-pulse linear accelerator (linac) which was designed to deliver an electron beam with variable dose-rates, ranging from a few Gy/min up to hundreds of Gy/s. It was built to study the radiobiological effects of high dose-per-pulse/dose-rate electron beam irradiation, in the context of preclinical and cognitive studies. In this work, we repo
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
Background and purpose: Adjuvant radiation therapy (RT) of the whole breast (WB) is still the standard treatment for early breast cancer. A variety of radiation techniques is currently available according to different delivery strategies. This study aims to provide a comparison of six treatment planning strategies commonly adopted for breast-conserving adjuvant RT and to use the Pareto concept in
Purpose: Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals. Experimental Design: Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate call
Background: Skin cancer incidence is rapidly increasing. The main risk factor, sun exposure, can be modified. Informational campaigns can be effective in raising skin cancer awareness and target the high-risk population. Still, sun exposure habits in people at high risk of skin cancer are not well-known.Objective: To investigate if and how sun exposure habits differ between low-risk and high-risk
This thesis deals with the general problem of controlling rigid-body systems through space, with a special focus on unmanned aerial vehicles (UAVs). Several promising UAV control algorithms have been developed over the past decades, enabling truly astounding feats of agility when combined with modern sensing technologies. However, these control algorithms typically come without global stability gu
Airborne wear particle emission has been investigated in a pin-on-disc tribometer equipped with particle analysis equipment. The pins are cut out fromcommercial powder metallurgy automotive brake pads as with and without copper content. The discs are cut out from a commercial grey cast iron automotive brake disc as cut out and as in addition to a laser cladded with a powder mix of Ni-self fluxing
Black carbon, as a series of light-absorbing carbonaceous material, contributes significantly to current global warming. Black carbon has always been considered a product of incomplete combustion of fossil fuels and vegetation. In the road transport sector, combustion exhaust is thought to be the primary source of black carbon. This study uses a pin-on-disc tribometer to simulate automotive disc b
Artificial football turf is today an increasingly common playing surface for athletics and kids. Its environmental impact is much debated, which is ranked as the second most common source of micro-plastic migration into nature. There are also concerns regarding the spread of inhalable airborne particles, originating from the wear between the football shoe-artificial turf contact. In this study a B
This article describes how a wheel–rail wear detection parameter based on noise was developed by running a rapid transit train instrumented with microphones in a depot with a small curve radius. This full-scale test made use of previous knowledge gained from lab-scale tests. The lab- and full-scale tests showed that noise could be used as an indicator of wear transition, when normal wear turns int
The abrasive wear behavior of traditional compacted graphite cast iron (CGI) and compacted graphite cast iron with 0.1% tin addition (CGI–Sn) is studied using a pin-on-disk tribometer. The microstructures of these two CGIs were observed by optical microscopy and scanning electron microscopy. The results show that Sn reduces the average size of vermicular graphite and promotes the generation of pea
Studded tyres wear surfaces of winter roads, generating inhalable airborne particles. In this study, four concrete road materials and two stud geometries were investigated in terms of wear, road material hardness and airborne particle concentration. The sliding contact between studded tyres and road materials was studied using a pin-on-disc machine in a clean chamber. The results show that the nor
A pin-on-disc tribometer placed in a one-way ventilated chamber was used to investigate the effect of relative humidity on the tribology and airborne particle emission of three commercial railway brake block materials (grey cast iron, organic composite, and sintered). Cast iron showed the highest friction coefficient, particle emission and wear loss and organic composite exhibited the lowest. The
The tiny contact zone (approximately 1 cm2) where steel wheel meets steel rail is fundamental to rail transport. This work is a comprehensive presentation of recent research in wheel-rail contact tribology. It stresses that, unlike gears or rolling bearings which are sealed contacts with reduced exposure to the surrounding environment, a wheel-rail contact is an open system that is exposed to dirt
The tribology of an open system at temperatures ranging between 3 °C and -35 °C, with and without snow, was investigated using a pin-on-disc tribometer mounted in a temperature-controlled environmental chamber. The relationship between the microstructure and ductility of the materials and the tribology at the contacting surfaces was investigated. The study shows that during continuous sliding, pre
The purpose of this work-package within the Quiet-track, FP7, is to develop a noise related track maintenance tool, in the form of an on-board measurement system. As a first step, lab scale tests using a pin-on-disc tribometer were used in order to distinguish how noise changes when the wear mechanism in a sliding contact shifts from normal wear to severe and catastrophic wear. Once the potential
This experiment investigated the effect of tin in an amount up to 0·121 wt-% on the microstructure and mechanical properties of compacted graphite iron. Graphite and matrix evolution was emphasised with the help of scanning electron microscopy. The results indicate that Sn in experimental range reduces graphite size. Pearlite quantity would increase with the increasing Sn and reaches over 95% when
