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Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOEɛ4 in the Betula Cohort

It is widely known that the apolipoprotein E (APOE) ɛ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOEɛ4 carriers than in non-carriers. Air pollution and interaction with APOE

The importance of migratory connectivity for global ocean policy

The distributions of migratory species in the ocean span local, national and international jurisdictions. Across these ecologically interconnected regions, migratory marine species interact with anthropogenic stressors throughout their lives. Migratory connectivity, the geographical linking of individuals and populations throughout their migratory cycles, influences how spatial and temporal dynami

Ontogenetic development of serotoninergic neurons in the brain of a teleost, the three-spined stickleback. An immunohistochemical analysis

The ontogenetic development of serotoninergic neurons in the brain of the stickleback was investigated with the indirect immunocytochemical peroxidase-antiperoxidase technique, using a specific antibody to serotonin (5-hydroxytryptamine, 5-HT). Formation of neuronal populations takes place during embryonic development. By 80 h after fertilization, the first 5-HT perikarya have appeared in the vent

Distribution of choline acetyltransferase‐immunoreactive neurons in the brain of a cyprinid teleost (Phoxinus phoxinus L.)

The distribution of putative cholinergic neurons in the brain of a cyprinid teleost was investigated by immunocytochemistry, with well‐characterized polyclonal antibodies to porcine choline acetyltransferase (ChAT), correlated with acetylcholinesterase (AChE) histochemistry. AChE‐positive neurons were more numerous than GhAT‐immunoreactive (ChAT‐IR) neurons. Regions with ChAT‐IR neurons generally

In situ high-resolution structure of the baseplate antenna complex in Chlorobaculum tepidum

Photosynthetic antenna systems enable organisms harvesting light and transfer the energy to the photosynthetic reaction centre, where the conversion to chemical energy takes place. One of the most complex antenna systems, the chlorosome, found in the photosynthetic green sulfur bacterium Chlorobaculum (Cba.) tepidum contains a baseplate, which is a scaffolding super-structure, formed by the protei

Identifying medullary bone in extinct avemetatarsalians : challenges, implications and perspectives

Medullary bone (MB) is a sex-specific tissue produced by female birds during the laying cycle, and it is hypothesized to have arisen within Avemetatarsalia, possibly outside Avialae. Over the years, researchers have attempted to define a set of criteria from which to evaluate the nature of purported MB-like tissues recovered from fossil specimens. However, we argue that the prevalence, microstruct

“The information has moved away from home” : Conceptions about how an outsourcing policy affects public records management

Traditionally, public records have been handled and preserved by each creating or receiving agency separately. The existing legal framework in Sweden is still based on this principle. However, recent developments – digital technologies paired with new ways of working – create a more dispersed and complex body of archives. What this means for the practical records management can be discussed. This

Kidney Function During Ageing and its Association with Bone Mass, Fracture and Mortality

Osteoporosis and osteoporosis related fractures are a major health care challenge both in Sweden and globally. The cost and suffering from osteoporosis are expected to increase since the population of elderly is increasing. Bone health can be affected by altered mineral homeostasis, which in its turn can be affected by reduced kidney function. However, the course of age-related decline in kidney f

Private equity, layoffs, and job polarization

Private equity firms are often criticized for laying off workers, but the evidence on who loses their jobs and why is scarce. This paper argues that explanations for job polarization also explain layoffs after private equity buyouts. Buyouts reduce agency problems, which triggers automation and off shoring. Using rich employer-employee data, we show that buyouts generally do not affect unemploymen

Simulation of pervaporation-based hybrid processes to recover organic compounds from waste water

Hybrid-processes combining pervaporation with a conventional separation process to recover organic compounds from waste water has been critically reviewed. Previous research which focused primarily on hydrophobic pervaporation combined with either adsorption, liquid-liquid phase separation, or reverse osmosis showed that these processes offered significant advantages over the exclusive use of just

Optimization of GaN Nanowires Reformation Process by Metalorganic Chemical Vapor Deposition for Device-Quality GaN Templates

Herein, the potential of reformed GaN nanowires (NWs) fabricated by metalorganic chemical vapor deposition (MOCVD) for device-quality low-defect density templates and low-cost alternative to bulk GaN substrates is demonstrated. The effects of epilayer thickness and NW reformation conditions on the crystalline quality and thermal conductivity of the subsequent GaN epilayers are investigated. Smooth

Single-Phase Borophene on Ir(111) : Formation, Structure, and Decoupling from the Support

Artificial two-dimensional (2D) materials, which host electronic or spatial structure and properties not typical for their bulk allotropes, can be grown epitaxially on atomically flat surfaces; the design and investigation of these materials are thus at the forefront of current research. Here we report the formation of borophene, a planar boron allotrope, on the surface of Ir(111) by exposing it t

Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation

Lysine methylation is a frequent post-translational protein modification, which has been intensively studied in the case of histone proteins. Lysine methylations are also found on many non-histone proteins, and one prominent example is eukaryotic elongation factor 1 alpha (eEF1A). Besides its essential role in the protein synthesis machinery, a number of non-canonical functions have also been desc

Search for bottom-squark pair production with the ATLAS detector in final states containing Higgs bosons, b-jets and missing transverse momentum

The result of a search for the pair production of the lightest supersymmetric partner of the bottom quark (b˜ 1) using 139 fb−1 of proton-proton data collected at s = 13 TeV by the ATLAS detector is reported. In the supersymmetric scenarios considered both of the bottom-squarks decay into a b-quark and the second-lightest neutralino, b˜1→b+χ˜20. Each χ˜20 is assumed to subsequently decay with 100%