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Universities, operating at the intersection of state, market, and civil society, are increasingly called upon to address urgent global challenges, such as climate change, inequalities, and social injustice. This has given rise to hybrid roles for scholars, ranging from public intellectuals to policy advisers and academic entrepreneurs. Among these roles, scholar-activism stands out by explicitly a

Hjärtat består av fyra hålrum; två kammare och två förmak, som separeras av fyra hjärtklaffar. Dessa säkerställer att blodet enbart flödar åt ett håll och ger därmed hjärtat förutsättningarna för effektiv pumpning av blodet. Mitralisklaffen är en av dessa fyra hjärtklaffar och separerar vänster förmak från vänster kammare, vilket gör att den utsätts för det högsta trycket i hjärtat. För att mitralThe heart consists of four chambers, two atria and two ventricles, separated by four valves that ensure unidirectional blood flow and efficient cardiac function. Among these, the mitral valve regulates blood flow between the left atrium and left ventricle and is one of the most mechanically loaded structures in the heart, stabilized by the chordae tendineae, which are connective structures. Conseq

Precision-cut lung slices (PCLS) have gained increasing interest as a model to study lung biology and disease, as well as for screening novel therapeutics. In particular, PCLS derived from human tissue can better recapitulate some aspects of lung biology and disease as compared to PCLS derived from animals (e.g. clinical heterogeneity), but access to human tissue is limited. A number of different

Single cell sequencing technologies (scRNA-seq, scATAC-seq, etc.) have revolutionized the study of complex tissues and unique organisms, providing researchers with a much needed species agnostic tool to study biological processes at the cellular level. To date, scRNA-seq technologies are expensive, require sufficient cell quantities, and need biological replicates to avoid batch effects or artifac

This paper documents how the advent of the limited liability corporation contributed to the diffusion of steam technology during Sweden's industrialization. Using longitudinal establishment-level data, we show that incorporation sharply raised the probability that industrial establishments adopted steam. Incorporation facilitated technology adoption partly by enabling smaller establishments to exp

To study the mechanisms of relapse in KMT2A-rearranged (KMT2A-r) acute lymphoblastic (ALL) and acute myeloid leukemia (AML), we performed whole-genome and exome sequencing of infants and children with relapsed ALL/AML (n = 36), and longitudinal deep-sequencing of 257 samples in 30 patients. Somatic alterations in drug-response genes, most commonly in TP53 and IKZF1 (64%), were highly enriched in e

Background: Dementia is a global public health challenge, with Alzheimer's disease (AD) and vascular dementia (VaD) being the most prevalent subtypes. Air pollution is a potential risk factor for dementia, but few studies separate AD and VaD. Objective: This study aims to investigate whether exposure to air pollution is associated with the incidence of AD and VaD. Methods: This study involved 30,2

Sorption-enhanced steam reforming (SorESR) is an advanced thermochemical process integrating in-situ CO2 capture via solid sorbents to significantly enhance hydrogen production and purity. By coupling CO2 adsorption with steam reforming, SorESR shifts the reaction equilibrium toward increased H₂ yield, surpassing the limitations of conventional steam reforming (SR). The efficacy of SorESR critical

Purpose: A cancer diagnosis and treatment pose significant physical and psychological challenges. The study aimed to explore factors associated with distress over time in women diagnosed with breast cancer undergoing radiotherapy (RT) with access to a digital information tool, specifically examining if factors such as health literacy and self-efficacy had any influence on distress. Methods: In thi

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene. This leads to progressive loss of striatal neurons and motor-cognitive decline. While current gene-targeting approaches aiming at reducing somatic instability show promise – especially in case of early treatment – they cannot restore the already compromised neuronal circuitry at advanc

Context In most cases of non-islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2, has been suggested to be coexpressed with IGF-II. Objective The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a

Konstantin den stores liv var dramatiskt som få. Född under osäkra omständigheter, så att vi inte ens kan säga vilket år han föddes, klättrade han till makten i början av 300-talet. I en tid då romerska kejsare inte blev långlivade skulle han regera längst av alla, i över trettio år, och under den tiden skrev han om historien. På vägen såg han visioner, erövrade han Rom, mördade han sin hustru och

Background: Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We analysed the impact of changing age-specific mortality (epidemiology) and age structure (demography) on crude death rates (CDRs) and causes of death with large or rising mortality to inform the third Lancet Commission on Investing in Health. Methods: Data from the World Populati

Giant number fluctuations (GNFs), whereby the standard deviation ΔN in the local number of particles ⟨N⟩ grows faster than sqrt[⟨N⟩], are a hallmark property of dry active matter systems with orientational order, such as a collection of granular particles on a vibrated plate. This contrasts with momentum-conserving ("wet") active matter systems, such as suspensions of swimming bacteria, where no t

We study the electronic structure of bulk 1T-TaSe_{2} in the charge-density wave phase at low temperature. Our spatially and angle-resolved photoemission data show insulating areas coexisting with metallic regions characterized by a chiral Fermi surface and moderately correlated quasiparticle bands. Additionally, high-resolution laser angle-resolved photoemission reveals variations in the metallic